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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamate-cysteine ligase, catalytic subunit

GCS, glucosylceramide synthase
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, AGE, ACID
Papers using GCS antibodies
Papers on GCS
Frameshift Mutations of AKAP9 Gene in Gastric and Colorectal Cancers with High Microsatellite Instability.
New
Lee et al., Seoul, South Korea. In Pathol Oncol Res, Feb 2016
We analyzed the mutations in 79 GCs and 124 CRCs including high MSI (MSI-H) and microsatellite stable/low MSI (MSS/MSI-L) cases by single-strand conformation polymorphism analysis and DNA sequencing.
The impact of genetic factors on response to glucocorticoids therapy in IBD.
New
Dobrowolska et al., Poznań, Poland. In Scand J Gastroenterol, Feb 2016
UNASSIGNED: Glucocorticosteroids (GCs) are used for many years as first-line drugs for the achievement of remission in exacerbations of inflammatory bowel disease (IBD).
The Glucocorticoid Receptor: Cause or Cure for Obesity?
Review
New
Hinds et al., Toledo, Philippines. In Am J Physiol Endocrinol Metab, Jan 2016
UNASSIGNED: Glucocorticoid hormones (GCs) are important regulators of lipid metabolism, promoting lipolysis with acute treatment but lipogenesis with chronic exposure.
PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones.
New
Impact
Rajewsky et al., Berlin, Germany. In Immunity, Jan 2016
Upon FOXO1 ablation or induction of PI3K activity, GCs lost their DZ, owing at least partly to downregulation of the chemokine receptor CXCR4.
The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program.
New
Impact
Dalla-Favera et al., New York City, United States. In Immunity, Jan 2016
In this study we show that FOXO1 transcription factor expression was restricted to the GC DZ and was required for DZ formation, since its absence in mice led to the loss of DZ gene programs and the formation of LZ-only GCs.
Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8.
New
Impact
Singh et al., Cincinnati, United States. In Nat Immunol, Dec 2015
Upon recognition of antigen, B cells undertake a bifurcated response in which some cells rapidly differentiate into plasmablasts while others undergo affinity maturation in germinal centers (GCs).
Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages.
New
Hu et al., Shanghai, China. In Plos One, Dec 2015
On the other hand, the glucosylceramide synthase (GCS) inhibitor PDMP or the ceramide (C6) potentiated Aldo-induced HUVEC apoptosis.
Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus.
New
Nishi et al., Kurume, Japan. In Plos One, Dec 2015
In the dentate gyrus, chronic fluoxetine treatment induces increased excitability of mature granule cells (GCs) as well as neurogenesis.
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
New
Shi et al., Nanning, China. In Theriogenology, Dec 2015
BMP1 is located in the oogonium of the fetal buffalo ovary and in the granulosa cells (GCs) and the oocytes of adult ovary from the primordial to the large antral follicles.
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
New
Impact
Crotty et al., Los Angeles, United States. In Nat Immunol, Sep 2015
Follicular helper T cells (T(FH) cells) are specialized effector CD4(+) T cells that help B cells develop germinal centers (GCs) and memory.
Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma.
New
Impact
Nussenzweig et al., New York City, United States. In Cell, Sep 2015
Pc induces prolonged expansion of germinal centers (GCs), unique compartments in which B cells undergo rapid clonal expansion and express activation-induced cytidine deaminase (AID), a DNA mutator.
Treating to target in established rheumatoid arthritis: Challenges and opportunities in an era of novel targeted therapies and biosimilars.
Review
New
den Broeder et al., Los Angeles, United States. In Best Pract Res Clin Rheumatol, Aug 2015
Rapid disease control can be achieved by "bridging" with various regimens of glucocorticoids (GCs), but tapering to doses ≤7.5 mg/day is critical to limit side effects.
[Biosynthesis of cyclic GMP in plant cells - new insight into guanylate cyclases].
Review
Szmidt-Jaworska et al., In Postepy Biochem, 2014
Concentration of this second messenger in plant cell is determined by guanylyl cyclases (GCs) responsible for cGMP synthesis and phosphodiesterases (PDEs) involved in cGMP inactivation.
Protein and Signaling Networks in Vertebrate Photoreceptor Cells.
Review
Dell'Orco et al., Oldenburg, Germany. In Front Mol Neurosci, 2014
It is catalyzed by membrane bound sensory guanylate cyclases (GCs) and is regulated by specific neuronal Ca(2+)-sensor proteins called guanylate cyclase-activating proteins (GCAPs).
MIF: Implications in the Pathoetiology of Systemic Lupus Erythematosus.
Review
Harris et al., Australia. In Front Immunol, 2014
MIF is distinct from all other cytokines by virtue of its unique induction by and counter regulation of glucocorticoids (GCs).
High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis.
GeneRIF
Kiessling et al., Stockholm, Sweden. In J Mol Med (berl), 2012
Data show for the first time that GCLC may serve a dual role, as a surrogate marker for cellular redox state as well as malignant potential of melanoma cells.
Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase.
GeneRIF
Orr et al., Dallas, United States. In Mech Ageing Dev, 2012
Microarray analysis revealed that glutamate cysteine ligasec overexpression and thus enhanced glutathione production has a broad impact on gene expression that largely affects different processes in young and old flies.
HCV NS5A and NS5B enhance expression of human ceramide glucosyltransferase gene.
GeneRIF
Zheng et al., Wuhan, China. In Virol Sin, 2012
The authors conclude that hepatitis C virus proteins, especially NS5A and NS5B, have positive effects on the expression of human GlcT-1.
Activation of promoter activity of the catalytic subunit of γ-glutamylcysteine ligase (GCL) in brain endothelial cells by insulin requires antioxidant response element 4 and altered glycemic status: implication for GCL expression and GSH synthesis.
GeneRIF
Aw et al., Shreveport, United States. In Free Radic Biol Med, 2011
insulin increased GCLc promoter activity, which required a prerequisite increase or decrease in medium glucose
Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus.
GeneRIF
Corrêa-Giannella et al., São Paulo, Brazil. In Bmc Med Genet, 2010
The functional SNPs CYBA -675 T --> A and GCLC rs17883901, probably associated with cellular redox imbalances, modulate the risk for renal disease in the studied population of type 1 diabetes patients
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