GCN2, an old dog with new tricks.
Oslo, Norway. In Biochem Soc Trans, 2013
Gcn2 was first described in budding yeast as a serine/threonine protein kinase involved in the response to amino acid starvation and this is its best characterized role to date.
Nutrient sensing and metabolic stress pathways in innate immunity.
Toronto, Canada. In Cell Microbiol, 2013
Cells monitor nutrient availability through several highly conserved pathways that include the mTOR signalling axis regulated by AKT/PI3K, HIF and AMPK, as well as the GCN2/eIF2α integrated stress response pathway that provides cellular adaptation to amino acid starvation.
The metabolic sensor GCN2 branches out.
Minneapolis, United States. In Cell Metab, 2007
GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins.