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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Prolactin-induced protein

GCDFP-15, SABP, gp17
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, CD45, CEA, ACID
Papers on GCDFP-15
Markers of metastatic carcinoma of breast origin.
Kandalaft et al., Seattle, United States. In Histopathology, Jan 2016
These markers include gross cystic disease fluid protein-15 (GCDFP-15), mammaglobin, and GATA3.
Primary invasive extramammary Paget disease on penoscrotum: a clinicopathological analysis of 41 cases.
Kong et al., Wuhan, China. In Hum Pathol, Jan 2016
GCDFP-15 was expressed to a variable degree in 24 cases.
Significantly increased PELP1 protein expression in primary and metastatic triple-negative breast carcinoma: comparison with GATA3 expression and PELP1's potential role in triple-negative breast carcinoma.
Peng et al., Dallas, United States. In Hum Pathol, Dec 2015
PELP1 may have diagnostic utility for metastatic TNBC in appropriate settings, such as history of primary TNBC in cases where the primary is negative for GATA3, mammaglobin, and GCDFP-15.
Comparative Sensitivities and Specificities of Antibodies to Breast Markers GCDFP-15, Mammaglobin A, and Different Clones of Antibodies to GATA-3: A Study of 338 Tumors Using Whole Sections.
Gown et al., Seattle, United States. In Appl Immunohistochem Mol Morphol, Nov 2015
We sought to determine the potential utility of GATA-3 in identifying metastatic breast CA, and to compare its utility with the standard breast markers, GCDFP-15, and mammaglobin A. We identified an archival series of 338 formalin-fixed paraffin-embedded whole-tissue sections of various CAs.
Young investigator challenge: The utility of GATA3 immunohistochemistry in the evaluation of metastatic breast carcinomas in malignant effusions.
Roh et al., Ann Arbor, United States. In Cancer Cytopathol, Oct 2015
BACKGROUND: It is not uncommon to encounter challenges in the immunohistochemical confirmation of metastatic breast cancer given the limited sensitivities of mammaglobin and gross cystic disease fluid protein 15 (GCDFP-15/BRST-2) and the significant proportion of triple-negative breast carcinomas (ie, tumors that are negative for estrogen receptor [ER], and progesterone receptor [PgR], and human epidermal growth factor 2 [HER2]).
Intracystic Papillary Carcinoma in Male Breast with High Nuclear Grade: A Case Report.
Al Salloom, Buraydah, Saudi Arabia. In J Clin Diagn Res, Aug 2015
The tumour is consistently positive for GCDFP-15, ER or PR and negative for HER-2.
Breast carcinoma metastasis to the lacrimal gland: Two case reports.
Heegaard et al., Copenhagen, Denmark. In Oncol Lett, Aug 2015
The epithelial tumour cells stained positive for cytokeratin (1-8, 10, 14-16, 18 and 19), oestrogen receptor, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA) and gross cystic disease fluid protein 15 (GCDFP-15).
Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy.
Sang et al., Nanjing, China. In An Bras Dermatol, May 2015
They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1.
Androgen receptor-positive mucoepidermoid carcinoma: case report and literature review.
Inagaki et al., Nagoya, Japan. In Int J Surg Pathol, May 2015
Since the tumor was positive for AR, GCDFP-15, and HER2, SDC was first suspected, but it was also positive for CK5/6 and P63, and negative for S-100 protein and α-smooth muscle actin.
Extramammary Paget disease of the vulva with underlying mammary-like lobular carcinoma: a case report and review of the literature.
Milikowski et al., In Am J Dermatopathol, Apr 2015
Immunohistochemical staining showed a comparable profile in the Paget cells and in the invasive tumoral cells: CEA and CK7 positivity; GCDFP-15, ER focal positivity.
Ceruminous Adenoma of the External Auditory Canal: A Case Report with Imaging and Pathologic Findings.
Markou et al., Thessaloníki, Greece. In Case Report Med, 2014
The apocrine gland-related antigen GCDFP-15 was focally expressed by tumor cells.
Encapsulated papillary carcinoma, apocrine type, of the breast.
Ichihara et al., Kōchi, Japan. In Malays J Pathol, 2014
The cytoplasm of the tumour cells showed positive immunostaining for GCDFP-15.
Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation.
Frenkel et al., Los Angeles, United States. In J Cell Physiol, 2012
Data suggest that Runx2 controls a positive feedback loop between androgen signaling and PIP, and pharmacological inhibition of PIP may be useful to treat PIP positive tumors.
Human serum albumin as a new interacting partner of prolactin inducible protein in human seminal plasma.
Yadav et al., New Delhi, India. In Int J Biol Macromol, 2012
The first report of native human serum albumin (HSA)-PIP complex formation in seminal plasma.
Association of prolactin-induced protein with preputial development of hypospadias.
Hayashi et al., Nagoya, Japan. In Bju Int, 2012
abnormal development of the prepuce in hypospadias is associated with variation in PIP expression
Relationship between molecular subtype of invasive breast carcinoma and expression of gross cystic disease fluid protein 15 and mammaglobin.
Argani et al., Baltimore, United States. In Am J Clin Pathol, 2011
Most basal-like breast carcinomas and unclassified triple-negative carcinomas are negative for mammaglobin and gross cystic disease fluid protein 15.
Generation and initial characterization of the prolactin-inducible protein (PIP) null mouse: accompanying global changes in gene expression in the submandibular gland.
Myal et al., Winnipeg, Canada. In Can J Physiol Pharmacol, 2009
these studies lend support to an immunomodulatory role for PIP in vivo and provide further insights into potentially novel signaling pathways and regulatory networks for PIP
The structure of the phage T4 DNA packaging motor suggests a mechanism dependent on electrostatic forces.
Rao et al., West Lafayette, United States. In Cell, 2009
We report the crystal structure of the DNA packaging motor protein, gene product 17 (gp17), in bacteriophage T4.
A charged performance by gp17 in viral packaging.
Tainer et al., Los Angeles, United States. In Cell, 2009
Through structural analyses of the T4 bacteriophage packaging motor gp17, Sun et al. (2008) now propose a packaging mechanism in which electrostatic forces cause the motor to alternate between tensed and relaxed conformational states.
Use of GCDFP-15 (BRST-2) as a Specific Immunocytochemical Marker for Diagnosis of Gastric Metastasis of Breast Carcinoma.
Park et al., In Cancer Res Treat, 2003
Immunohistochemical staining with GCDFP-15 (gross cystic disease fluid protein-15) can be used to differentiate primary gastric carcinoma and gastric metastasis from breast cancer.
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