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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Guanylate cyclase 2C

GC-C, guanylyl cyclase C
guanylyl cyclase; functions as receptor for heat-stable enterotoxin responsible for acute diarrhea [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Sar1, uroguanylin, fibrillin-1, ACID, CAN
Papers on GC-C
Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.
New
Waldman et al., Philadelphia, United States. In Cancer Res, Feb 2016
During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universally to malignant progression.
Measurement of natural carbon isotopic composition of acetone in human urine.
New
Yoshimura et al., Yokohama, Japan. In Anal Bioanal Chem, Jan 2016
UNASSIGNED: The natural carbon isotopic composition of acetone in urine was measured in healthy subjects using gas chromatography-combustion-isotope ratio mass spectrometry combined with headspace solid-phase microextraction (HS-SPME-GC-C-IRMS).
Carbon Stable Isotope Analysis of Methylmercury Toxin in Biological Materials by Gas Chromatography Isotope Ratio Mass Spectrometry.
New
Richard et al., Toulouse, France. In Anal Chem, Jan 2016
Here, we present a compound-specific stable isotope analysis (CSIA) technique for the determination of the δ(13)C value of CH3Hg in biological samples by gas chromatography combustion isotope ratio mass spectrometry analysis (GC-C-IRMS).
Development and validation of a GC-C-IRMS method for the confirmation analysis of pseudo-endogenous glucocorticoids in doping control.
New
Botrè et al., Roma, Italy. In Drug Test Anal, Dec 2015
We are proposing an analytical method based on gas chromatography coupled to isotope ratio mass spectrometry (GC-C-IRMS) which allows discrimination between endogenous and synthetic origin of the urinary metabolites of the pseudo-endogenous glucocorticoids.
Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis.
New
Plevy et al., United States. In World J Gastrointest Pharmacol Ther, Dec 2015
RESULTS: Plecanatide and dolcanatide are structurally related analogs of uroguanylin, which is an endogenous ligand of guanylate cyclase-C (GC-C).
Products for the treatment of inflammatory bowel disease: a patent review (2013 - 2014).
Review
New
Witaicenis et al., Botucatu, Brazil. In Expert Opin Ther Pat, Jun 2015
On the other hand, methods and strategies using new formulations of conventional drugs, guanylyl cyclase C peptide agonists, compounds that influence anti-adhesion molecules, mAbs anti-type I interferons and anti-integrin, oligonucleotide antisense Smad7, growth factor neuregulin 4 and functional foods, particularly fermented wheat germ with Saccharomyces cerevisiae, are promising products for use in the very near future.
[Pain therapy in irritable bowel syndrome].
Review
Andresen et al., Hamburg, Germany. In Schmerz, 2014
Modern drug treatments include the GC-C agonist linaclotide in IBS with predominant constipation, the locally acting antibiotic rifaximin in IBS with bloating, and 5-HT3 antagonists in IBS with predominant diarrhea.
Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain.
Review
Silos-Santiago et al., Cambridge, United States. In Front Mol Neurosci, 2013
Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation, and release of cyclic guanosine-3',5'-monophosphate (cGMP).
Current understanding of guanylin peptides actions.
Review
Sindic, Zagreb, Croatia. In Isrn Nephrol, 2012
In the intestine, a well-known receptor for GPs is guanylate cyclase C (GC-C) whose activation increases intracellular concentration of cGMP.
Pendrin, a novel transcriptional target of the uroguanylin system.
Review
Zelikovic et al., Haifa, Israel. In Cell Physiol Biochem, 2012
The cellular function of GN and UGN in intestine and proximal tubule is mediated by guanylyl cyclase C (GC-C)-, cGMP-, and G protein-dependent pathways, whereas, in principal cells of the cortical collecting duct (CCD), these peptide hormones act via GC-C-independent signaling through phospholipase A2 (PLA2).
Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C.
GeneRIF
Birk et al., Beersheba, Israel. In Am J Hum Genet, 2012
Mutations in GUCY2C were associated with the Meconium ileus phenotype. downregulation of GUCY2C leads to a cystic fibrosis-like intestinal phenotype.
Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C.
GeneRIF
Waldman et al., Philadelphia, United States. In Cancer Immunol Immunother, 2012
The role for GUCY2C-directed CD8(+) T cells targeting specific epitopes in antitumor efficacy.
Familial diarrhea syndrome caused by an activating GUCY2C mutation.
Impact
GeneRIF
Knappskog et al., Bergen, Norway. In N Engl J Med, 2012
We identified a heterozygous missense mutation (c.2519G-->T) in GUCY2C in all family members with familial diarrhea syndrome.
Peripheral blood guanylyl cyclase c (GCC) expressions are associated with prognostic parameters and response to therapy in colorectal cancer patients.
GeneRIF
Demiryürek et al., Gaziantep, Turkey. In Tumour Biol, 2011
Data suggest that monitoring the peripheral blood GCC expressions may allow employing different treatment options to metastatic CRC patients.
GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity.
GeneRIF
Waldman et al., Philadelphia, United States. In Plos One, 2011
GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity
Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior.
Impact
GeneRIF
Luo et al., Beijing, China. In Science, 2011
midbrain dopamine neurons express GC-C; GC-C activation potentiates excitatory response mediated by glutamate and acetylcholine receptors via activity of PKG; GC-C knockout mice exhibit hyperactivity and attention deficit
Chemistry of archaeological animal fats.
Review
Impact
Crossman et al., Bristol, United Kingdom. In Acc Chem Res, 2002
The origins of preserved fats have been determined through detailed compositional analysis of their component fatty acids by GC, by GC/MS of dimethyl disulfide derivatives of monoenoic components, and by GC-combustion-isotope ratio-MS (GC-C-IRMS), to derive diagenetically robust delta(13)C values.
Ectopic expression of guanylyl cyclase C in CD34+ progenitor cells in peripheral blood.
Impact
Waldman et al., Philadelphia, United States. In J Clin Oncol, 2001
PURPOSE: To examine the utility of guanylyl cyclase C (GC-C)-specific nested reverse transcriptase polymerase chain reaction (RT-PCR) to detect circulating tumor cells in patients with colorectal cancer.
Guanylyl cyclase is a heat-stable enterotoxin receptor.
Impact
Garbers et al., Nashville, United States. In Cell, 1990
We describe a new clone (GC-C) encoding a guanylyl cyclase receptor for heat-stable enterotoxin.
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