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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

MTOR associated protein, LST8 homolog

GBL, LST8, mLST8, Lst8p, GbetaL
cytosolic protein similar to an insulin receptor [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, mTOR, mTORC1, mTORC2, HAD
Papers on GBL
Architecture of human mTOR complex 1.
New
Impact
Maier et al., Zürich, Switzerland. In Science, Feb 2016
We resolved the architecture of human mTORC1 (mTOR with subunits Raptor and mLST8) bound to FK506 binding protein (FKBP)-rapamycin, by combining cryo-electron microscopy at 5.9 angstrom resolution with crystallographic studies of Chaetomium thermophilum Raptor at 4.3 angstrom resolution.
The hippocampus participates in a pharmacological rat model of absence seizures.
New
Stan Leung et al., London, Canada. In Epilepsy Res, Jan 2016
OBJECTIVE: Using the gamma-butyrolactone (GBL) model of absence seizures in Long-Evans rats, this study investigated if 2.5-6Hz paroxysmal discharges (PDs) induced by GBL were synchronized among the thalamocortical system and the hippocampus, and whether inactivation of the hippocampus affected PDs.
Analysis on the Physicochemical Properties of Ginkgo biloba Leaves after Enzymolysis Based Ultrasound Extraction and Soxhlet Extraction.
New
Tao et al., Nanjing, China. In Molecules, Dec 2015
In this study, high performance liquid chromatography (HPLC), ultraviolet (UV), thermagravimetric analyzer (TGA), pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS), and scanning electron microscope (SEM) were used as measurement techniques, contents of chemical composition, pyrolytic products, thermal stability, morphological characterization of Ginkgo biloba leaves (GBL) acted as the index, and physicochemical properties of GBL after enzymolysis based ultrasound extraction (EBUE) and Soxhlet extraction were studied.
Characterization of a gamma-butyrolactone synthetase gene homologue (stcA) involved in bafilomycin production and aerial mycelium formation in Streptomyces sp. SBI034.
New
Panbangred et al., Bangkok, Thailand. In Appl Microbiol Biotechnol, Dec 2015
Addition of exogenous γ-butyrolactone (GBL) extracted from the culture broth of the wild-type strain could stimulate the aerial mycelium and spore formation of the stcA disruptant.
Targeted inhibition of Rictor/mTORC2 in cancer treatment: a new era after rapamycin.
New
Bai et al., Guangzhou, China. In Curr Cancer Drug Targets, Dec 2015
mTORC1, consisting of mTOR, raptor, and mLST8 (GβL), is sensitive to rapamycin and thought to control autonomous cell growth in response to nutrient availability and growth factors.
Mode of DNA binding with γ-butyrolactone receptor protein CprB from Streptomyces coelicolor revealed by site-specific fluorescence dynamics.
New
Anand et al., Mumbai, India. In Biochim Biophys Acta, Nov 2015
BACKGROUND: The γ-butyrolactone (GBL) binding transcription factors in Streptomyces species are known for their involvement in quorum sensing where they control the expression of various genes initiating secondary metabolic pathways.
Regulation of mTORC1 by PI3K signaling.
Review
New
Cantley et al., Boston, United States. In Trends Cell Biol, Sep 2015
Activation of mTORC1 [composed of mTOR, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8(mLST8), 40-kDa proline-rich Akt substrate (PRAS40), and DEP domain-containing mTOR-interacting protein (DEPTOR)] depends on the Ras-related GTPases (Rags) and Ras homolog enriched in brain (Rheb) GTPase and requires signals from amino acids, glucose, oxygen, energy (ATP), and growth factors (including cytokines and hormones such as insulin).
[Analysis of GHB and Its Precursors in Urine and Their Forensic Application].
New
Shen et al., In Fa Yi Xue Za Zhi, Jun 2015
OBJECTIVE: To establish the method to analyze γ-hydroxybutyric acid (GHB) and its precursors 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL) in urine through LC-MS/MS and provide evidence for related cases.
GHB pharmacology and toxicology: acute intoxication, concentrations in blood and urine in forensic cases and treatment of the withdrawal syndrome.
Review
Jones et al., Roma, Italy. In Curr Neuropharmacol, 2015
Although GHB is listed as a controlled substance in many countries abuse still continues, owing to the availability of precursor drugs, γ-butyrolactone (GBL) and 1,4-butanediol (BD), which are not regulated.
PIKKs--the solenoid nest where partners and kinases meet.
Review
Williams et al., Cambridge, United Kingdom. In Curr Opin Struct Biol, 2014
The recent structure of a truncated mTOR in a complex with mLST8 has provided a basic framework for understanding all of the phosphoinositide 3-kinase (PI3K)-related kinases (PIKKs): mTOR, ATM, ATR, SMG-1, TRRAP and DNA-PK.
The structural basis for mTOR function.
Review
Williams et al., Cambridge, United Kingdom. In Semin Cell Dev Biol, 2014
The active site is deeply recessed and flanked by structural elements unique to the PIKKs, namely, the FRB domain, the LST8 binding element, and a C-terminal stretch of helices known as the FATC domain.
GHB, GBL and 1,4-BD addiction.
Review
van den Brink et al., Utrecht, Netherlands. In Curr Pharm Des, 2013
Its precursors gammabutyrolactone (GBL) and 1,4-butanediol (1,4-BD) show the same properties and may pose even more risks due to different pharmacokinetics.
mTOR kinase structure, mechanism and regulation.
Impact
Pavletich et al., New York City, United States. In Nature, 2013
Here we report co-crystal structures of a complex of truncated mTOR and mammalian lethal with SEC13 protein 8 (mLST8) with an ATP transition state mimic and with ATP-site inhibitors.
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Impact
Baur et al., Cambridge, United States. In Science, 2012
Further, decreased mTORC1 signaling was sufficient to extend life span independently from changes in glucose homeostasis, as female mice heterozygous for both mTOR and mLST8 exhibited decreased mTORC1 activity and extended life span but had normal glucose tolerance and insulin sensitivity.
Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro.
GeneRIF
Zhong et al., Wuhan, China. In Autophagy, 2012
An essential role of mTORC1 in autophagy inhibition in cell-free system in which, membrane association of Barkor/Atg14(L), a specific autophagosome-binding protein, is suppressed by cytosol from nutrient-rich medium, is shown.
mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway.
GeneRIF
Kitamura et al., Japan. In Cell Death Differ, 2012
These results disclosed that, under endoplasmic reticulum stress conditions, mTORC1 causes apoptosis through suppression of Akt and consequent induction of the IRE1-JNK pathway.
Antagonistic control of muscle cell size by AMPK and mTORC1.
GeneRIF
Viollet et al., Paris, France. In Cell Cycle, 2011
the crosstalk between AMPK and mTORC1 signaling is a highly regulated way to control changes in muscle growth and metabolic rate imposed by external cues.
Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4.
GeneRIF
Martin et al., United States. In Arterioscler Thromb Vasc Biol, 2011
Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4
Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57.
GeneRIF
Vázquez-Prado et al., Mexico. In Mol Cell Biol, 2011
results suggest that GRp58/ERp57 is involved in the assembly of mTORC1 and positively regulates mTORC1 signaling at the cytosol and the cytosolic side of the endoplasmic reticulum
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Impact
Hall et al., Basel, Switzerland. In Nat Cell Biol, 2004
mTORC2 contains mTOR, mLST8 and mAVO3, but not raptor.
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