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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mesenchyme homeobox 2

GAX, Meox2, Mox2
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Meox1, ACID, p21, V1a
Papers using GAX antibodies
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
Supplier
Deng Chu-Xia et al., In International Journal of Biological Sciences, 1992
... Mox2-Cre transgenic mice ...
Papers on GAX
Master regulators in primary skin fibroblast fate reprogramming in a human ex-vivo model of chronic wounds.
New
Dugast-Darzacq et al., Paris, France. In Wound Repair Regen, Jan 2016
Conversely, downregulation of MEOX2, SIX2 and MAF causes reprogramming of fibroblasts to myofibroblasts even in absence of TGFbeta, the natural inducer of myofibroblast differentiation.
Activation of Transcription Factor GAX and Concomitant Downregulation of IL-1β and ERK1/2 Modulate Vascular Smooth Muscle Cell Phenotype in 3D Fibrous Scaffolds.
New
Mequanint et al., London, Canada. In Tissue Eng Part A, Sep 2015
An early burst of expression of IL-1β is essential for suppression of the homeobox transcription factor Gax and related cyclin-dependent kinase inhibitor p21(Cip1), which are key regulators for cells exiting from cell cycle.
Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer.
Buckingham et al., Paris, France. In Biol Open, 2014
We show that Msx1 and Meox2 homeodomain-containing transcription factors bind in vitro and in vivo to specific sites in the 145-bp element, and are implicated in fine-tuning activation of Myf5 in the forelimb.
Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population.
Staessen et al., Leuven, Belgium. In Bmc Genet, 2014
BACKGROUND: In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport.
HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice.
Sopori et al., Albuquerque, United States. In Plos One, 2014
This response was associated with increased alveolar volumes, higher levels of proapoptotic factors (FOXO3a, HIPK2, p53, BIM, BIK, and BAX) and the antiangiogenic factor (GAX), and lower levels of antiapoptotic factors (Akt-PI3K, NF-κB, HIF-1α, and Bcl-2) in the lung.
Gamma scintigraphic study of the hydrodynamically balanced matrix tablets of Metformin HCl in rabbits.
Noordin et al., Kuala Lumpur, Malaysia. In Drug Des Devel Ther, 2014
MOX2 formulation, composed of salep and xanthan in the ratio of 4:1 with 96.9% release, was considered as the optimum formulation with more than 90% release in 12 hours and short floating lag time.
Regional divergence of palate medial edge epithelium along the anterior to posterior axis.
Ding et al., Louisville, United States. In Int J Dev Biol, 2013
Recent studies have shown that mouse palatal mesenchymal cells undergo regional specification along the anterior-posterior (A-P) axis defined by anterior Shox2 and Msx1 expression and posterior Meox2 expression.
The imbalance of vascular molecules in Alzheimer's disease.
Review
Bell, Rochester, United States. In J Alzheimers Dis, 2011
In particular, the vascular-specific transcription factors MEOX2, MYOCD, and SRF, genetic risk factor APOE4, transport proteins LRP1 and RAGE, and circulating molecules such as sLRP1, homocysteine, and albumin are discussed.
miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.
GeneRIF
Thum et al., Hannover, Germany. In Embo Rep, 2011
The miRNA family miR-130/301/721 enhances induced pluripotent stem cells generation via repression of Meox2.
Involvement of Gax gene in hypoxia-induced pulmonary hypertension, proliferation, and apoptosis of arterial smooth muscle cells.
GeneRIF
Bai et al., Shanghai, China. In Am J Respir Cell Mol Biol, 2011
Hypoxia suppressed the expression of endogenous Gax in rats, but not in those pretreated intratracheally with a Gax construct.
Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.
GeneRIF
Wigle et al., Winnipeg, Canada. In Plos One, 2010
MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner.
MEOX2 regulates nuclear factor-kappaB activity in vascular endothelial cells through interactions with p65 and IkappaBbeta.
GeneRIF
Gorski et al., New Brunswick, United States. In Cardiovasc Res, 2010
Report of an interaction between a homeobox protein and IkappaBbeta in endothelial cells and suggest that MEOX2 modulates the activity of the RelA complex through direct interaction with its components.
Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor.
GeneRIF
Kaneko et al., Saitama, Japan. In Genes Chromosomes Cancer, 2009
Loss of MEOX2 gene is associated with Wilms tumor.
[Negative regulation of cells proliferation by Gax gene and its mechanisms].
Review
Qian et al., Shanghai, China. In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2009
Gax gene is a newly found negative transcriptional regulator of cells proliferation.
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease.
Review
Zlokovic et al., Rochester, United States. In Curr Alzheimer Res, 2007
In addition, we have identified two vascularly restricted genes, GAX (growth arrest-specific homeobox), which controls LRP1 expression in brain capillaries and brain angiogenesis, and MYOCD (myocardin), which controls contractility of cerebral arterial smooth muscle cells and influences cerebral blood flow.
Cerebrovascular gene linked to Alzheimer's disease pathology.
Review
de la Torre, Cleveland, United States. In Trends Mol Med, 2005
Now, a new study by Zlokovic and colleagues reveals that the vascular gene MEOX2 has a low expression in cultured brain endothelial cells from AD patients.
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease.
Impact
GeneRIF
Zlokovic et al., Rochester, United States. In Nat Med, 2005
The link of MEOX2 to neurovascular dysfunction in Alzheimer disease provides new mechanistic and therapeutic insights into this illness.
The formation of skeletal muscle: from somite to limb.
Review
Relaix et al., Paris, France. In J Anat, 2003
These include Pax3 with its target c-met, Lbx1 and Mox2 as well as the myogenic determination factors Myf5 and MyoD and factors required for differentiation such as Myogenin, Mrf4 and Mef2 isoforms.
Early specification of limb muscle precursor cells by the homeobox gene Lbx1h.
Impact
Braun et al., Halle, Germany. In Nat Genet, 1999
7), Mox2 (ref.
Mox2 is a component of the genetic hierarchy controlling limb muscle development.
Impact
Pachnis et al., London, United Kingdom. In Nature, 1999
Mox1 and Mox2 are closely related homeobox genes that are expressed in overlapping patterns in the paraxial mesoderm and its derivatives.
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