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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

GATA binding protein 6

This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: GATA4, CAN, HAD, ACID, POLYMERASE
Papers using GATA6 antibodies
Papers on GATA6
Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve.
Bossé et al., Québec, Canada. In Am J Cardiol, Mar 2016
Nine genes previously associated with BAV (NOTCH1, AXIN1, EGFR, ENG, GATA5, NKX2-5, NOS3, PDIA2, and TGFBR2) were sequenced in 48 patients with BAV using the Ion Torrent Personal Genome Machine.
Discovery of signature genes in gastric cancer associated with prognosis.
Ma et al., In Neoplasma, Feb 2016
A total of 17 genes were identified as signature genes, such as DAB2, ALDH2, CD58, CITED2, BNIP3L, SLC43A2, FAU and COL5A1.Many signature genes associated with prognosis of GC were identified in present study, some of which have been implicated in the pathogenesis of GC.
GATAe regulates intestinal stem cell maintenance and differentiation in Drosophila adult midgut.
Adachi-Yamada et al., Tokyo, Japan. In Dev Biol, Jan 2016
Since recent reports showed that mammalian GATA-6 regulates normal and cancer stem cells in the adult intestinal tract, our data also provide information on the evolutionally conserved roles of GATA factors in stem-cell regulation.
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.
Weiss et al., Cambridge, United States. In Nat Commun, Dec 2015
With a genetically engineered pulse of GATA-binding protein 6 (GATA6) expression, we initiate rapid emergence of all three germ layers as a complex function of GATA6 expression levels and tissue context.
Genome, Exome, and Targeted Next-Generation Sequencing in Neonatal Diabetes.
Ellard et al., Exeter, United Kingdom. In Pediatr Clin North Am, Aug 2015
For neonatal diabetes, the use of these technologies has resulted in the identification of 2 novel disease genes (GATA6 and STAT3) and a novel regulatory element of PTF1A, in which mutations cause pancreatic agenesis.
Molecular biology of endometriosis: from aromatase to genomic abnormalities.
Dyson et al., Chicago, United States. In Semin Reprod Med, May 2015
Defective CpG methylation affecting several genes that encode key transcription factors such as GATA6, steroidogenic factor-1, and estrogen receptor-β in endometriosis gives rise to overproduction of local estrogen and prostaglandins and suppression of progesterone receptor.
Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer.
AIFEG et al., Varese, Italy. In Clin Epigenetics, 2014
In all four classes, hypermethylation of ESR1, GATA5, and WT1 was very common.
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.
Batlle et al., Barcelona, Spain. In Nat Cell Biol, 2014
Here we screen for genes required for maintaining the tumour stem cell phenotype and identify the zinc-finger transcription factor GATA6 as a key regulator of the WNT and BMP pathways in CRC.
Tissue-specific signals control reversible program of localization and functional polarization of macrophages.
Medzhitov et al., New Haven, United States. In Cell, 2014
Here, we identified retinoic acid as a signal that induces tissue-specific localization and functional polarization of peritoneal macrophages through the reversible induction of transcription factor GATA6.
Hopping between differentiation states in lung adenocarcinoma.
Meyerson et al., Boston, United States. In Cancer Cell, 2013
The work by Cheung and colleagues, in this issue of Cancer Cell, demonstrates another example of how lineage-specific transcriptional regulators of differentiation, GATA6 and HOPX, can control the fate of lung adenocarcinoma progression.
Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.
Nguyen et al., New Haven, United States. In Cancer Cell, 2013
This program is regulated in part by the lineage transcription factors GATA6 and HOPX.
GATA6 is required for proliferation, migration, secretory cell maturation, and gene expression in the mature mouse colon.
Krasinski et al., Boston, United States. In Mol Cell Biol, 2012
In the colon, Gata6 deletion resulted in shorter, wider crypts, a decrease in proliferation, and a delayed crypt-to-surface epithelial migration rate.
Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif.
Solway et al., Chicago, United States. In Biochem J, 2012
USF1 transactivates GATA5 expression by binding to the E-box in its promoter
Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease.
Semsarian et al., Australia. In J Mol Cell Cardiol, 2012
Rare non-synonymous variations in the functionally important GATA5 transcriptional activation domains may be important in the pathogenesis of BAV disease in humans.
cAMP-dependent proteolysis of GATA-6 is linked to JNK-signaling pathway.
Maeda et al., Japan. In Biochem Biophys Res Commun, 2012
In this study, they examined whether or not the JNK signaling pathway participates in the cAMP-dependent proteolysis of GATA-6 since a JNK inhibitor, SP600125, inhibited the proteolysis.
Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
Azuara et al., London, United Kingdom. In Genes Dev, 2012
Bmi1 overlaps with the nascent Gata6 and Nanog protein from the eight-cell stage onward before it preferentially cosegregates with Gata6 in primitive endoderm progenitors
GATA6 haploinsufficiency causes pancreatic agenesis in humans.
Ellard et al., Exeter, United Kingdom. In Nat Genet, 2012
These findings define the most common cause of human pancreatic agenesis and establish a key role for the transcription factor GATA6 in human pancreatic development.
Transition-metal ions in zeolites: coordination and activation of oxygen.
Schoonheydt et al., Leuven, Belgium. In Inorg Chem, 2010
O(2)-activated Co intermediates in faujasite (FAU) zeolites can selectively oxidize alpha-pinene and epoxidize styrene.
[The GATA family in reproduction].
Wang et al., China. In Zhonghua Nan Ke Xue, 2009
GATA-4 and GATA-6 have been identified in the ovaries and testes of humans, mice, pigs and chickens.
15-lipoxygenase-1 in colorectal cancer: a review.
Khan et al., Nuneaton, United Kingdom. In Tumour Biol, 2008
Regulation of 15-LOX-1 expression is achieved at transcription level by global histone acetylation and may also be dependent on GATA-6, IL-4 and IL-13.
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