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GATA binding protein 4

This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Nkx2.5, CAN, GATA6, V1a, HAD
Papers using GATA4 antibodies
Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia
Cheng Juei-Tang et al., In Cardiovascular Diabetology, 2009
... Antibodies of phospho-GATA-4 (serine105) (AB5245) and laminin (AB11575) were purchased from Abcam (Cambridge, UK) ...
Notch1 signaling stimulates proliferation of immature cardiomyocytes
Giacca Mauro et al., In The Journal of Cell Biology, 2007
... Anti-Notch-1 (C-20), anti-Jagged1 (H-114), anti-Delta (F15), anti–cyclin-A (C19), anti–cyclin-D1 (C20), anti–cyclin-E (C19), anti-p27Kip1 (C-19), and anti–GATA-4 antibodies were obtained from Santa Cruz Biotechnology, Inc.; anti–cleaved Notch-1 (Val1744), ...
Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle
Komuro Issei et al., In The Journal of Cell Biology, 2002
... monoclonal anti-cTnT (RV-C2, DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH), goat polyclonal anti-cTnT, goat polyclonal anti-GATA4 (Santa Cruz Biotechnology, Inc.), rabbit polyclonal anti-ANF ...
Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription.
Andre Frederic, In PLoS ONE, 2000
... Antibody against GATA4 and the horseradish peroxidase-conjugated anti-rabbit and anti-goat antibodies were from Santa Cruz Biotechnology, Inc ...
Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis
Okada Hitoshi et al., In The Journal of Cell Biology, 1998
... ), Hsp70-2/HspA2 (M06; Abnova Corp.), calretinin (Santa Cruz Biotechnology, Inc.), and Gata-4 (Santa Cruz Biotechnology, Inc.) ...
Papers on GATA4
Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling.
Murry et al., Seattle, United States. In Proc Natl Acad Sci U S A, Feb 2016
This approach correctly identified known stage-specific markers of cardiomyocyte differentiation, including SRY-box2 (SOX2), GATA binding protein 4 (GATA4), and myosin heavy chain 6 (MYH6).
Ventricular cell fate can be specified until the onset of myocardial differentiation.
Latinkic et al., Cardiff, United Kingdom. In Mech Dev, Feb 2016
We show that in this model pluripotent animal cap explants injected with cardiogenic factor GATA4 mRNA express pan-myocardial as well as ventricular and proepicardial markers.
HO-1/CO system and embryonic stem cell differentiation and maturation into cardiomyocytes.
Piantadosi et al., Durham, United States. In Antioxid Redox Signal, Feb 2016
Targeted HO-1/CO interventions up- and down-regulate specific cardiogenic transcription factors GATA4, Nkx2.5, Hand1, and MEF2C.
Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells.
Mohan et al., Kuala Lumpur, Malaysia. In Drug Des Devel Ther, Dec 2015
Expression of cardiac-specific genes showed that treated MSCs expressed significantly higher levels of cardiac troponin-T, Nkx2.5, and GATA-4 compared with untreated cells.
Expression profile of FGF receptors in preimplantation ovine embryos and the effect of FGF2 and PD173074.
Nasr-Esfahani et al., Eşfahān, Iran. In Growth Factors, Oct 2015
Assessment of expression profiles of lineage-associated markers revealed that FGF2 (500 ng/ml) supplementation: (i) significantly increased expression of putative hypoblast marker (GATA4), (ii) significantly decreased expression of putative epiblast (EPI) marker (NANOG) and (iii) did not change TE markers (CDX2 and IFNT) and pluripotency makers (OCT4, SOX2 and REX1).
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Elledge et al., Boston, United States. In Science, Oct 2015
We have identified the transcription factor GATA4 as a senescence and SASP regulator.
Human sex-determination and disorders of sex-development (DSD).
McElreavey et al., Paris, France. In Semin Cell Dev Biol, Sep 2015
SOX family gene mutations, as well as mutations involving GATA4, FOG2 and genes involved in MAP kinase signaling have been associated with virilization in 46,XX individuals or with 46,XY gonadal dysgenesis.
Morphogenesis and molecular considerations on congenital cardiac septal defects.
Jongbloed et al., Leiden, Netherlands. In Ann Med, 2014
NODAL and GATA4) may lead to defects at all levels.
Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders.
Pu et al., Cambridge, United States. In Cold Spring Harb Perspect Med, 2014
In this review, we discuss monogenic CHD caused by mutations of the cardiac transcription factor genes NKX2-5 and GATA4.
Adult granulosa cell tumours of the ovary.
Colombo et al., Roma, Italy. In Curr Opin Oncol, 2014
RECENT FINDINGS: Novel biomarkers, including FOXL2, SMAD3 and GATA4, have been identified as potential diagnostic and therapeutic targets for this type of tumour.
BET-ting on chromatin-based therapeutics for heart failure.
McKinsey et al., Cleveland, United States. In J Mol Cell Cardiol, 2014
Studies of transcriptional mechanisms in heart failure have focused heavily on roles of sequence-specific DNA-binding factors such as NFAT, MEF2 and GATA4.
Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling.
Scorrano et al., Genève, Switzerland. In Science, 2013
Gene expression profiling revealed decreased levels of transcription factors transforming growth factor-β/bone morphogenetic protein, serum response factor, GATA4, and myocyte enhancer factor 2, linked to increased Ca(2+)-dependent calcineurin activity and Notch1 signaling that impaired ESC differentiation.
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Bassel-Duby et al., Dallas, United States. In Nat Rev Mol Cell Biol, 2013
Heart function has been restored in rodents by reprogramming non-myocytes into cardiomyocytes, by expressing transcription factors (GATA4, HAND2, myocyte-specific enhancer factor 2C (MEF2C) and T-box 5 (TBX5)) and microRNAs (miR-1, miR-133, miR-208 and miR-499) that control cardiomyocyte identity.
GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1).
Noguchi et al., Bethesda, United States. In J Biol Chem, 2012
a novel role for GATA-4 and TAL1 to affect skeletal myogenic differentiation and EPO response via cross-talk with Sirt1.
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.
Wu et al., Boston, United States. In Circ Res, 2012
Induction of Gata4/Mef2c/Tbx5 overexpression in fibroblasts is inefficient at inducing molecular and electrophysiological phenotypes of mature cardiomyocytes.
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Olson et al., Dallas, United States. In Nature, 2012
Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro.
Novel GATA4 mutations in patients with congenital ventricular septal defects.
Fang et al., Shanghai, China. In Med Sci Monit, 2012
These findings expand the mutation spectrum of GATA4 linked to ventricular septal defect.
Promyelocytic leukemia zinc finger protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2.
Inagami et al., Nashville, United States. In Plos One, 2011
PLZF activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2.
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.
Garg et al., Columbus, United States. In Plos Genet, 2011
the Gata4 G295S mutation functions as a hypomorph in vivo and leads to defects in cardiomyocyte proliferation during embryogenesis, which may contribute to the development of congenital heart defects in humans.
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes.
Poss et al., Durham, United States. In Nature, 2010
Through the use of a transgenic reporter strain, we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of the embryonic cardiogenesis gene gata4 within a week of trauma
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