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GATA binding protein 3

GATA3
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: TH2, T-bet, BET, IL-4, CAN
Papers on GATA3
Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment.
New
Impact
Zhu et al., Bethesda, United States. In Nat Immunol, Feb 2016
The transcription factor GATA-3 is indispensable for the development of all innate lymphoid cells (ILCs) that express the interleukin 7 receptor α-chain (IL-7Rα).
The role of GATA3 in breast carcinomas: a review.
Review
New
Cimino-Mathews et al., Baltimore, United States. In Hum Pathol, Feb 2016
GATA3 is a zinc-binding transcription factor that regulates the differentiation of many human tissue types, including the mammary gland.
Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation.
New
Renz et al., Marburg an der Lahn, Germany. In Int Arch Allergy Immunol, Feb 2016
Very high levels of maternal folate were significantly associated with increased H3/H4 acetylation at GATA3 and/or IL9 promoter regions in CD4+ T cells in CB.
Identification of a Th2 and Th17 Skewed Immune Phenotype in Chronic Urticaria with Th22 Reduction Dependent on Autoimmunity and Thyroid Disease Markers.
New
Nazarian et al., Boston, United States. In J Cutan Pathol, Feb 2016
METHODS: Biopsies of chronic urticaria (n=11) and normal skin (n=5) were evaluated with immunostains for CD117, CD3 and dual stains for CD4/T-bet, GATA-3, STAT-3, or BNC-2 (transcription factors specific and mutually exclusive for Th1, Th2, Th17, and Th22 cells, respectively).
Depletion of CD8+ T Cells Exacerbates CD4+ T Cell-Induced Monocyte-to-Fibroblast Transition in Renal Fibrosis.
New
Du et al., Beijing, China. In J Immunol, Feb 2016
CD4(+) T cells isolated from CD8 KO obstructed kidney expressed more IL-4 and GATA3 and less IFN-γ and T-bet and showed increased monocyte-to-fibroblast transition in vitro compared with those isolated from wild-type obstructed kidney.
NK Cell-Specific Gata3 Ablation Identifies the Maturation Program Required for Bone Marrow Exit and Control of Proliferation.
New
Lee et al., Ottawa, Canada. In J Immunol, Feb 2016
Although the developmental program leading to mature NK cells has been studied in the context of several transcription factors, the stage-specific role of GATA3 in NK cell development has been incompletely understood.
Systematic discovery of complex insertions and deletions in human cancers.
New
Impact
Ding et al., Saint Louis, United States. In Nat Med, Jan 2016
We discovered 285 complex indels in cancer-associated genes (such as PIK3R1, TP53, ARID1A, GATA3 and KMT2D) in approximately 3.5% of cases analyzed; nearly all instances of complex indels were overlooked (81.1%) or misannotated (17.6%) in previous reports of 2,199 samples.
Markers of metastatic carcinoma of breast origin.
Review
New
Kandalaft et al., Seattle, United States. In Histopathology, Jan 2016
These markers include gross cystic disease fluid protein-15 (GCDFP-15), mammaglobin, and GATA3.
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.
New
Impact
Maris et al., Philadelphia, United States. In Nature, Jan 2016
We show that the newly evolved protective TATA allele is associated with decreased total LMO1 expression (P = 0.028) in neuroblastoma primary tumours, and ablates GATA3 binding (P < 0.0001).
A Novel De Novo GATA Binding Protein 3 Mutation in a Turkish Boy with Hypoparathyroidism, Deafness, and Renal Dysplasia Syndrome.
New
Hatun et al., İstanbul, Turkey. In J Clin Res Pediatr Endocrinol, Jan 2016
Hypoparathyroidism, deafness, and renal dysplasia (HDR; OMIM 146255) syndrome is a rare disease, inherited dominantly and found to be related with GATA3 (GATA binding protein 3) gene mutations.
Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis.
Review
New
Gevaert et al., Gent, Belgium. In J Allergy Clin Immunol, Dec 2015
Future concepts using upstream targets, such as GATA-3, also focus on this endotype.
Integrated molecular analysis of adult T cell leukemia/lymphoma.
New
Impact
Ogawa et al., Kyoto, Japan. In Nat Genet, Nov 2015
We also discovered frequent intragenic deletions involving IKZF2, CARD11 and TP73 and mutations in GATA3, HNRNPA2B1, GPR183, CSNK2A1, CSNK2B and CSNK1A1.
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
New
Impact
Perou et al., Lausanne, Switzerland. In Cell, Nov 2015
Conversely, GATA3 mutations and high expression characterized luminal A IDC, suggesting differential modulation of ER activity in ILC and IDC.
Somatic mutations in breast and serous ovarian cancer young patients: a systematic review and meta-analysis.
Review
New
Folgueira et al., São Paulo, Brazil. In Rev Assoc Med Bras, Oct 2015
TP53 somatic mutation was described in 20% of tumors from both younger and older patients; PTEN, CDH1 and GATA3 somatic mutation was investigated only in 16 patients and PTEN mutation was detected in one of them.
GATA3 in Breast Cancer: Tumor Suppressor or Oncogene?
Review
Wade et al., United States. In Gene Expr, 2014
GATA3 is a highly conserved, essential transcription factor expressed in a number of tissues, including the mammary gland.
BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers.
GeneRIF
Mullan et al., Belfast, United Kingdom. In Oncogene, 2012
the BRCA1-GATA3 interaction is important for the repression of genes associated with triple-negative and basal-like breast cancer (BLBCs) including FOXC1
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation.
Impact
GeneRIF
Nakayama et al., Chiba, Japan. In Nat Immunol, 2012
Sox4 was induced by TGF-beta and negatively regulated the transcription factor GATA-3, the master regulator of function of T helper type 2 TH2 cells, by two distinct mechanisms.
The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.
GeneRIF
Watson et al., Cambridge, United Kingdom. In Genes Dev, 2012
this study explores the role of Zfp157 in alveologenesis and reveals that this transcriptional regulator controls the balance of luminal populations and is a critical mediator of Gata-3 signaling.
GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry.
GeneRIF
Engel et al., Ann Arbor, United States. In Blood, 2012
Data show that GATA-3 is required for the maintenance of a normal number of long-term repopulating HSC (LT-HSC) and for their entry into the cell cycle.
[Expression of transcription factors T-bet and GATA-3 and relationship to the numbers of eosinophils in rat model of allergic rhinitis].
GeneRIF
Liu et al., Nanchang, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2011
The imbalance of transcription factor GATA-3 and T-bet has a close correlation with the eosinophil count, and may play a key role in the formation of allergic rhinitis.
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