Identification of a Th2 and Th17 Skewed Immune Phenotype in Chronic Urticaria with Th22 Reduction Dependent on Autoimmunity and Thyroid Disease Markers.
Boston, United States. In J Cutan Pathol, Feb 2016
METHODS: Biopsies of chronic urticaria (n=11) and normal skin (n=5) were evaluated with immunostains for CD117, CD3 and dual stains for CD4/T-bet, GATA-3, STAT-3, or BNC-2 (transcription factors specific and mutually exclusive for Th1, Th2, Th17, and Th22 cells, respectively).
Systematic discovery of complex insertions and deletions in human cancers.
Saint Louis, United States. In Nat Med, Jan 2016
We discovered 285 complex indels in cancer-associated genes (such as PIK3R1, TP53, ARID1A, GATA3 and KMT2D) in approximately 3.5% of cases analyzed; nearly all instances of complex indels were overlooked (81.1%) or misannotated (17.6%) in previous reports of 2,199 samples.