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GATA binding protein 2

GATA2
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: GATA-1, CAN, GATA3, CK7, HAD
Papers using GATA2 antibodies
Distinguishing regulatory DNA from neutral sites.
Supplier
Fugmann Sebastian D., In PLoS ONE, 2002
... Antibodies were anti-AR (N20), anti-HNF-3α (H-120), anti-NFI (H-300), anti-C/EBPβ (C19), anti-GATA2 (H116), normal rabbit IgG (Santa Cruz Biotechnology, Santa Cruz, CA), anti-Oct1 ...
Regulation of neuronal specification in the zebrafish spinal cord by Delta function
Supplier
Eisen Judith S et al., In Neural Development, 1997
... Tg(gata2:GFP) [53] and Tg(pax2a:GFP) [54] transgenic lines ...
Papers on GATA2
Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.
New
Xu et al., Boston, United States. In Dev Cell, Feb 2016
GATA2-to-GATA1 switch is prevalent at dynamic enhancers and drives erythroid enhancer commissioning.
FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.
New
Yu et al., Chicago, United States. In Oncogene, Feb 2016
UNASSIGNED: Hormonal regulation of gene expression by androgen receptor (AR) is tightly controlled by many transcriptional cofactors, including pioneer factors FOXA1 and GATA2, which, however, exhibit distinct expression patterns and functional roles in prostate cancer.
Successful reduced-intensity stem cell transplantation for GATA2 deficiency before progression of advanced MDS.
New
Adachi et al., Kyoto, Japan. In Pediatr Transplant, Feb 2016
The patient was diagnosed with Emberger syndrome by sequencing of GATA2 DNA, and underwent RIST from an HLA-matched unrelated donor.
Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.
Review
New
Mitsiades et al., Houston, United States. In Horm Cancer, Feb 2016
In this review, we discuss the preclinical research that has been done, as well as clinical trials for prostate cancer, on inhibiting several important families of AR-interacting proteins, including chaperones (such as heat shock protein 90 (HSP90) and FKBP52), pioneer factors (including forkhead box protein A1 (FOXA1) and GATA-2), and AR transcriptional coregulators such as the p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2, SRC-3, as well as lysine deacetylases (KDACs) and lysine acetyltransferases (KATs).
Whole-exome sequencing reveals a C-terminal germline variant in CEBPA-associated acute myeloid leukemia: 45-year follow-up of a large family.
New
Stewart et al., David, Panama. In Haematologica, Jan 2016
UNASSIGNED: Familial acute myeloid leukemia is rare and linked to germline mutations in RUNX1, GATA2 or CCAAT/enhancer binding protein-α (CEBPA).
Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.
New
Impact
Majeti et al., Stanford, United States. In Cell Stem Cell, Jan 2016
These effects are restricted to immature HSPC populations, where cohesin mutants show increased chromatin accessibility and likelihood of transcription factor binding site occupancy by HSPC regulators including ERG, GATA2, and RUNX1, as measured by ATAC-seq and ChIP-seq.
Host susceptibility to non-tuberculous mycobacterial infections.
Review
New
Holland et al., Bethesda, United States. In Lancet Infect Dis, Aug 2015
GATA2 deficiency and anti-interferon γ autoantibodies also give rise to disseminated infection, typically in late childhood or adulthood.
Mutations in the BCR-ABL1 Kinase Domain and Elsewhere in Chronic Myeloid Leukemia.
Review
New
Martinelli et al., Bologna, Italy. In Clin Lymphoma Myeloma Leuk, Jun 2015
Mutations in genes other than BCR-ABL1 include ASXL1, TET2, RUNX1, DNMT3A, EZH2, and TP53 in chronic phase patients and RUNX1, ASXL1, IKZF1, WT1, TET2, NPM1, IDH1, IDH2, NRAS, KRAS, CBL, TP53, CDKN2A, RB1, and GATA-2 mutations in advanced phase patients.
Taxane resistance in prostate cancer mediated by AR-independent GATA2 regulation of IGF2.
New
Impact
Balk et al., Seattle, United States. In Cancer Cell, Mar 2015
GATA2 has been well-characterized as a critical pioneer transcription factor for androgen receptor (AR) in prostate cancer.
A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer.
New
Impact
Domingo-Domenech et al., New York City, United States. In Cancer Cell, Mar 2015
We used experimental models and clinical databases to identify GATA2 as a regulator of chemotherapy resistance and tumorigenicity in this context.
Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell transplantation.
Cammenga et al., Lund, Sweden. In Leuk Res Rep, 2014
Heterozygous mutations in GATA2 underlie different syndromes, previously described as monocytopenia and mycobacterial avium complex infection (MonoMAC); dendritic cell, monocytes, B- and NK lymphocytes deficiency (DCML); lymphedema, deafness and myelodysplasia (Emberger syndrome) and familiar myelodysplastic syndrome/acute myeloid leukemia (MDS / AML).
GATA family transcriptional factors: emerging suspects in hematologic disorders.
Review
Peterson et al., Chicago, United States. In Exp Hematol Oncol, 2014
The three important GATA transcription factors GATA1, GATA2 and GATA3 play essential roles in the development and maintenance of hematopoietic systems.
Primary Immunodeficiencies Associated with EBV Disease.
Review
Cohen, Bethesda, United States. In Curr Top Microbiol Immunol, 2014
These include diseases due to mutations in PIK3CD, PIK3R1, CTPS1, STK4, GATA2, MCM4, FCGR3A, CARD11, ATM, and WAS.
A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression.
Impact
Yamamoto et al., Sendai, Japan. In Cancer Cell, 2014
In this study, we identified a mechanism whereby a GATA2 distal hematopoietic enhancer (G2DHE or -77-kb enhancer) is brought into close proximity to the EVI1 gene in inv(3)(q21;q26) inversions, leading to leukemogenesis.
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia.
Impact
Delwel et al., Rotterdam, Netherlands. In Cell, 2014
Applying functional genomics and genome-engineering, we demonstrate that both 3q rearrangements reposition a distal GATA2 enhancer to ectopically activate EVI1 and simultaneously confer GATA2 functional haploinsufficiency, previously identified as the cause of sporadic familial AML/MDS and MonoMac/Emberger syndromes.
GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia.
GeneRIF
Bohlander et al., München, Germany. In Blood, 2012
mutational screening detected novel GATA2 ZF1 mutations in 13 of 33 biallelic CEBPA-positive cytogenetically normal-AML patients
Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
GeneRIF
Sen et al., Columbus, United States. In Arterioscler Thromb Vasc Biol, 2012
Injury-induced repression of miR-200b turned on wound angiogenesis. In mice with diabetes mellitus,excessive tumor necrosis factor-alpha induced miR-200b blunting proangiogenic functions of GATA2 and VEGFR2.
The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish.
GeneRIF
Muller et al., Köln, Germany. In Mol Endocrinol, 2012
Sox4b is expressed in zebrafish during pituitary development and plays a crucial role in the differentiation of thyrotrope and gonadotrope cells through induction of gata2a expression
GATA2 is expressed at critical times in the mouse uterus during pregnancy.
GeneRIF
DeMayo et al., Houston, United States. In Gene Expr Patterns, 2012
Study reports that GATA2 protein is expressed in the uterine luminal and glandular epithelium pre-implantation, spatio-temporally co-localizing with that of the progesterone receptor.
The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.
Impact
GeneRIF
Downward et al., London, United Kingdom. In Cell, 2012
In a Kras-driven NSCLC mouse model, Gata2 loss dramatically reduced tumor development. Furthermore, Gata2 deletion in established Kras mutant tumors induced striking regression
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