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GATA binding protein 1

GATA-1
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, GATA2, CK7, V1a, PU.1
Papers on GATA-1
Novel players in β-thalassemia dyserythropoiesis and new therapeutic strategies.
New
Courtois et al., Paris, France. In Curr Opin Hematol, Feb 2016
Blocking GDF11 alleviates anemia in a mouse model of β-thalassemia and also in humans, most likely by promoting cells of 'good' erythroblastic lineage containing an α-/non-α-globin chain ratio of close to 1. Maturation arrest at the polychromatophilic stage (step 3) is associated with the depletion of GATA binding protein 1 (GATA-1) from the nucleus, which results from cytoplasmic sequestration of heat shock protein 70 (HSP70) by α-globin chains.
Reprogramming of human peripheral blood monocytes to erythroid lineage by blocking of the PU-1 gene expression.
New
Ebrahimi et al., Tehrān, Iran. In Ann Hematol, Feb 2016
UNASSIGNED: In hematopoietic system development, PU.1 and GATA-1 as lineage-specific transcription factors (TF) are expressed in common myeloid progenitors.
Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.
New
Xu et al., Boston, United States. In Dev Cell, Feb 2016
GATA2-to-GATA1 switch is prevalent at dynamic enhancers and drives erythroid enhancer commissioning.
Prenatal therapy in transient abnormal myelopoiesis: a systematic review.
Review
New
Kilby et al., Birmingham, United Kingdom. In Arch Dis Child Fetal Neonatal Ed, Jan 2016
A novel case of GATA1-positive TAM, in which following serial in utero blood transfusion clinical improvement and postnatal remission were observed, is included.
A Child With Dyserythropoietic Anemia and Megakaryocyte Dysplasia Due to a Novel 5'UTR GATA1s Splice Mutation.
New
Nalepa et al., Indianapolis, United States. In Pediatr Blood Cancer, Jan 2016
We show that (i) this constellation of hematopoietic abnormalities was due to a germline mutation within the 5' untranslated region (5'UTR) of globin transcription factor 1 (GATA1); (ii) the mutation impaired a 5'UTR GATA1 splicing site, with promoted production of the shortened GATA1 isoform lacking the N-terminus; and (iii) expression of the GATA1 N-terminus is restricted to erythroblasts and megakaryocytes in normal marrow, consistent with the patient's abnormal erythropoiesis and megakaryopoiesis.
The biology of pediatric acute megakaryoblastic leukemia.
Review
New
Downing et al., Memphis, United States. In Blood, Sep 2015
AMKL in children with Down syndrome (DS) is characterized by a founding GATA1 mutation that cooperates with trisomy 21, followed by the acquisition of additional somatic mutations.
Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells.
Slukvin et al., Madison, United States. In J Vis Exp, 2014
The combination of ETV2 and GATA1 or GATA2 TFs is used to induce HE with pan-myeloid potential, while a combination of GATA2 and TAL1 transcription factors allows for the production of HE with erythroid and megakaryocytic potential.
GATA family transcriptional factors: emerging suspects in hematologic disorders.
Review
Peterson et al., Chicago, United States. In Exp Hematol Oncol, 2014
The three important GATA transcription factors GATA1, GATA2 and GATA3 play essential roles in the development and maintenance of hematopoietic systems.
Hematopoietic transcription factor mutations and inherited platelet dysfunction.
Review
Rao et al., Philadelphia, United States. In F1000prime Rep, 2014
These hematopoietic transcription factors include RUNX1, FLI1, GATA-1, and GFI1B.
Genetic heterogeneity in transient abnormal myelopoiesis.
Review
Saida, Kyoto, Japan. In Rinsho Ketsueki, 2014
We detected a GATA1 mutation but no copy number alterations (CNAs) in the primary patient sample by conventional genomic sequencing and CNA profiling.
HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia.
Impact
Courtois et al., Paris, France. In Nature, 2014
Although erythroid transcription factor GATA-1, the master transcriptional factor of erythropoiesis, is a caspase-3 target, it is not cleaved during erythroid differentiation.
Altered translation of GATA1 in Diamond-Blackfan anemia.
Impact
Sankaran et al., Boston, United States. In Nat Med, 2014
Here, we identify mutations in GATA1, encoding the critical hematopoietic transcription factor GATA-binding protein-1, that reduce levels of full-length GATA1 protein and cause DBA in rare instances.
Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors.
Impact
Enver et al., London, United Kingdom. In Cell Stem Cell, 2014
We combined global ChIP-seq of GATA1, GATA2, and PU.1 with expression profiling during differentiation to erythroid and neutrophil lineages.
The landscape of somatic mutations in Down syndrome-related myeloid disorders.
Impact
Ogawa et al., Tokyo, Japan. In Nat Genet, 2013
Pathogenesis of these Down syndrome-related myeloid disorders is poorly understood, except for GATA1 mutations found in most cases.
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Impact
Benoist et al., Boston, United States. In Nat Immunol, 2012
Enforced expression of Helios or Xbp1 elicited distinct signatures, but Eos, IRF4, Satb1, Lef1 and GATA-1 elicited exactly the same outcome, acting in synergy with Foxp3 to activate expression of most of the T(reg) cell signature, including key transcription factors, and enhancing occupancy by Foxp3 at its genomic targets.
GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis.
GeneRIF
Milot et al., Montréal, Canada. In Mol Cell Biol, 2012
results describe a mechanism whereby GATA-1 utilizes Ikaros and Polycomb repressive complex 2 to promote Hes1 repression as an important step in erythroid cell differentiation
Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1.
Impact
GeneRIF
Blobel et al., Philadelphia, United States. In Cell, 2012
Mitosis-specific destruction of GATA1 delays reactivation selectively of genes that retain GATA1 during mitosis; studies suggest a requirement of mitotic "bookmarking" by GATA1 for the faithful propagation of cell-type-specific transcription programs through cell division.
Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia.
GeneRIF
Gazda et al., Cambridge, United States. In J Clin Invest, 2012
newly identified mutations hightlight the multifactorial role of GATA1 in human hematopoiesis
N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program.
GeneRIF
Shimizu et al., Sendai, Japan. In J Biol Chem, 2012
GATA1 has two independent transactivation domains, N-TAD and C-TAD. Both N-TAD and C-TAD retain redundant as well as specific activities for proper hematopoiesis in vivo.
[GATA1-mutation associated leukemia in children with trisomy 21 mosaic].
GeneRIF
Kolenova et al., Hannover, Germany. In Klin Padiatr, 2012
GATA1s associated leukemia has to be excluded in all young children with AMKL (<5 years old) to prevent overtreatment. Treatment with reduced intensity seems sufficient in children trisomy 21 mosaic and ML-DS.
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