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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Mar 2015.


Gastrin, gastrin-17, G17
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cholecystokinin, ACID, HAD, Bombesin, somatostatin
Papers using Gastrin antibodies
Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor
Varro A. et al., In American Journal of Physiology - Gastrointestinal and Liver Physiology, 2005
... wortmannin were all from Calbiochem (Nottingham, UK), YM022 was from Tocris Bioscience (Bristol, UK), and gastrin-17 was from Bachem (St ...
Papers on Gastrin
Wehbi et al., Atlanta, United States. In Gastroenterol Rep (oxf), 18 Mar 2015
UNASSIGNED: Gastrin is an important hormone of the digestive system, which assists gastric acid secretion.
Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumor.
Benítez et al., Madrid, Spain. In Hum Mol Genet, 11 Mar 2015
Gastrin is involved in the endocrine regulation of gastric acid production.
Peptidyl hormones of endocrine cells origin in the gut - their discovery and physiological relevance.
Dembinski et al., Kraków, Poland. In J Physiol Pharmacol, 28 Feb 2015
Gastrin was discovered in 1905; whereas cholecystokinin in 1928.
Evaluation of Three Different Families of Bombesin Receptor Radioantagonists for Targeted Imaging and Therapy of Gastrin Releasing Peptide Receptor (GRP-R) Positive Tumors.
Maecke et al., Basel, Switzerland. In J Med Chem, 22 Feb 2015
Two new classes of radiolabeled GRP receptor antagonists are studied and compared with the well-established statine-based receptor antagonist DOTA-4-amino-1-carboxymethylpiperidine-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (RM2, 1; DOTA:1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; Sta:(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid).
Effect of fasting and refeeding on expression of genes involved in the gastric nutrient sensing and orexigenic control of pigs.
Bosi et al., Reggio nell'Emilia, Italy. In J Anim Physiol Anim Nutr (berl), Jan 2015
Gastrin expression tended to be higher in R than in C and F (p = 0.068 and p = 0.055).
Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach.
Fossmark et al., Trondheim, Norway. In Dig Dis Sci, Jan 2015
Gastric cancer occurs almost exclusively in patients with gastritis.
The Gastrin-Releasing Peptide Receptor (GRPR) in the Spinal Cord as a Novel Pharmacological Target.
Sakamoto et al., Kyoto, Japan. In Curr Neuropharmacol, Sep 2014
Gastrin-releasing peptide (GRP) is a mammalian neuropeptide that acts through the G protein-coupled receptor, GRP receptor (GRPR).
Gastrin-releasing peptide receptor signaling in the integration of stress and memory.
Merali et al., Porto Alegre, Brazil. In Neurobiol Learn Mem, Jul 2014
Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin.
Targeting GRPR in urological cancers--from basic research to clinical application.
Reubi et al., Freiburg, Germany. In Nat Rev Urol, 2013
Gastrin releasing peptide (GRP) is a regulatory peptide that acts through its receptor (GRPR) to regulate physiological functions in various organs.
Extraintestinal roles of bombesin-like peptides and their receptors: lung.
Qu et al., Changsha, China. In Curr Opin Endocrinol Diabetes Obes, 2013
RECENT FINDINGS: Gastrin-releasing peptide (GRP) was involved in the airway inflammation in murine models of airway hyperreactivity.
Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).
Patel et al., Melbourne, Australia. In Endocrinology, 2012
hypoxia up-regulates the gastrin gene in AGS cells by HIF-independent mechanisms
A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.
Seva et al., Toulouse, France. In Cancer Prev Res (phila), 2012
progastrin predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps
Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma.
Morii et al., Taiwan. In J Zhejiang Univ Sci B, 2012
a high level of PBX2 is a poor prognosticator for disease-free survival and overall survival in gingival squamous cell carcinoma
Immunohistochemical identification and localisation of gastrin and somatostatin in endocrine cells of human pyloric gastric mucosa.
Lewandowska et al., Białystok, Poland. In Folia Morphol (warsz), 2012
Investigation of the healthy human pylorus shows characteristic distribution of cells that react with antisera to gastrin and somatostatin.
Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers.
Sung et al., Stockholm, Sweden. In Scand J Gastroenterol, 2012
The fasting level of gastrin-17 is high in AG limited to the corpus and fundus, but low or non-elevated if the AG occurs in both antrum and corpus.
Serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy.
Wasilewska et al., Białystok, Poland. In Adv Med Sci, 2010
analysis of serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy
Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer.
Caplin et al., London, United Kingdom. In J Clin Oncol, 2002
Gastrin acts as a growth factor for pancreatic cancer.
Autoantibody to the gastrin receptor in pernicious anemia.
Toh et al., In N Engl J Med, 1985
We examined serum IgG fractions from 20 patients with pernicious anemia and 25 control subjects for their capacity to inhibit binding of [125I]15-leu human gastrin-17 to parietal-cell-enriched gastric mucosal cells.
Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase.
Monckton et al., In Nature, 1983
Such a sequence is also found adjacent to the phosphotyrosine of middle T antigen, and in the homologous region of the hormone gastrin, adjacent to a tyrosine which is sulphated in approximately half the gastrin isolated from gastric mucosa.
Evidence for coexistence of dopamine and CCK in meso-limbic neurones.
Markey et al., In Nature, 1980
In the CNS, true gastrin molecules, gastrin-17 and gastrin-34 have been located only in the neurohypophysis, hypothalamus and occasionally in the medulla oblongata (unpublished results).
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