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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

Gastrin

Gastrin, gastrin-17, G17
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cholecystokinin, ACID, HAD, Bombesin, somatostatin
Papers using Gastrin antibodies
Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor
Supplier
Varro A. et al., In American Journal of Physiology - Gastrointestinal and Liver Physiology, 2005
... wortmannin were all from Calbiochem (Nottingham, UK), YM022 was from Tocris Bioscience (Bristol, UK), and gastrin-17 was from Bachem (St ...
Papers on Gastrin
Long-term dynamics of gastric biomarkers after eradication of Helicobacter pylori infection.
New
Leja et al., Rīga, Latvia. In Eur J Gastroenterol Hepatol, 31 May 2015
BACKGROUND: Secretion of pepsinogen I (PgI), pepsinogen II (PgII), fasting gastrin-17 (fG-17) and stimulated gastrin-17 (sG-17) changes after Helicobacter pylori eradication.
The Anti-diabetic Effects of GLP-1-gastrin Dual Agonist ZP3022 in ZDF rats.
New
Fosgerau et al., Glostrup, Denmark. In Peptides, 04 May 2015
METHODS: ZDF rats aged 11 weeks were dosed s.c, b.i.d for 8 weeks with vehicle, ZP3022, liraglutide, exendin-4, or gastrin-17 with or without exendin-4.
IN-VITRO AND IN-VIVO APPLICATION OF RADIOLABELED GASTRIN RELEASING PEPTIDE RECEPTOR LIGANDS IN BREAST CANCER.
New
Melis et al., Bronkhorstspruit, South Africa. In J Nucl Med, 19 Apr 2015
Based on a similar rationale, radioligands targeting the gastrin releasing peptide receptor (GRP-R) might offer a specific method for imaging and therapy of BC.
CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells.
New
Jensen et al., Bethesda, United States. In J Mol Neurosci, 12 Apr 2015
Addition of CCK-8 or gastrin-17 (100 nM) to NCI-H727 human lung cancer cells increased EGFR Tyr(1068) phosphorylation after 2 min.
Hypergastrinemia.
Review
New
Wehbi et al., Atlanta, United States. In Gastroenterol Rep (oxf), 18 Mar 2015
UNASSIGNED: Gastrin is an important hormone of the digestive system, which assists gastric acid secretion.
Peptidyl hormones of endocrine cells origin in the gut--their discovery and physiological relevance.
New
Dembinski et al., Kraków, Poland. In J Physiol Pharmacol, Feb 2015
Gastrin was discovered in 1905; whereas cholecystokinin in 1928.
Anti-Gastrins Antiserum Combined with Lowered Dosage Cytotoxic Drugs to Inhibit the Growth of Human Gastric Cancer SGC7901 Cells in Nude Mice.
New
Wang et al., Xi'an, China. In J Cancer, Dec 2014
The anti-gastrin antiserum was obtained by immunizing rabbits using a novel immunogen vaccine, which was composed of the common amino-terminal portion of human carboxy-amidated gastrin-17 (G17) and glycine-extended gastrin-17 (gly-G17) and the common carboxy-terminal portion of progastrin (in a 50:50 mixture) all covalently linked to tetanus toxoid (TT) by specific peptide spacers.
Gastrin-releasing peptide receptor signaling in the integration of stress and memory.
Review
New
Merali et al., Porto Alegre, Brazil. In Neurobiol Learn Mem, Jul 2014
Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin.
Targeting GRPR in urological cancers--from basic research to clinical application.
Review
Reubi et al., Freiburg, Germany. In Nat Rev Urol, 2013
Gastrin releasing peptide (GRP) is a regulatory peptide that acts through its receptor (GRPR) to regulate physiological functions in various organs.
Extraintestinal roles of bombesin-like peptides and their receptors: lung.
Review
Qu et al., Changsha, China. In Curr Opin Endocrinol Diabetes Obes, 2013
RECENT FINDINGS: Gastrin-releasing peptide (GRP) was involved in the airway inflammation in murine models of airway hyperreactivity.
Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).
GeneRIF
Patel et al., Melbourne, Australia. In Endocrinology, 2012
hypoxia up-regulates the gastrin gene in AGS cells by HIF-independent mechanisms
A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.
GeneRIF
Seva et al., Toulouse, France. In Cancer Prev Res (phila), 2012
progastrin predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps
Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma.
GeneRIF
Morii et al., China. In J Zhejiang Univ Sci B, 2012
a high level of PBX2 is a poor prognosticator for disease-free survival and overall survival in gingival squamous cell carcinoma
Immunohistochemical identification and localisation of gastrin and somatostatin in endocrine cells of human pyloric gastric mucosa.
GeneRIF
Lewandowska et al., Białystok, Poland. In Folia Morphol (warsz), 2012
Investigation of the healthy human pylorus shows characteristic distribution of cells that react with antisera to gastrin and somatostatin.
Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers.
Review
Sung et al., Stockholm, Sweden. In Scand J Gastroenterol, 2012
The fasting level of gastrin-17 is high in AG limited to the corpus and fundus, but low or non-elevated if the AG occurs in both antrum and corpus.
Serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy.
GeneRIF
Wasilewska et al., Białystok, Poland. In Adv Med Sci, 2010
analysis of serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy
Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer.
Impact
Caplin et al., London, United Kingdom. In J Clin Oncol, 2002
Gastrin acts as a growth factor for pancreatic cancer.
Autoantibody to the gastrin receptor in pernicious anemia.
Impact
Toh et al., In N Engl J Med, 1985
We examined serum IgG fractions from 20 patients with pernicious anemia and 25 control subjects for their capacity to inhibit binding of [125I]15-leu human gastrin-17 to parietal-cell-enriched gastric mucosal cells.
Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase.
Impact
Monckton et al., In Nature, 1983
Such a sequence is also found adjacent to the phosphotyrosine of middle T antigen, and in the homologous region of the hormone gastrin, adjacent to a tyrosine which is sulphated in approximately half the gastrin isolated from gastric mucosa.
Evidence for coexistence of dopamine and CCK in meso-limbic neurones.
Impact
Markey et al., In Nature, 1980
In the CNS, true gastrin molecules, gastrin-17 and gastrin-34 have been located only in the neurohypophysis, hypothalamus and occasionally in the medulla oblongata (unpublished results).
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