Synthesis, antiviral activity, 3D-QSAR, and interaction mechanisms study of novel malonate derivatives containing quinazolin-4(3H)-one moiety.
Guiyang, China. In Bioorg Med Chem Lett, Feb 2016
Notably, compounds g15, g16, g17, and g18 exhibited excellent curative activities in vivo against CMV, with 50% effective concentration (EC50) values of 208.36, 153.78, 181.47, and 164.72μg/mL, respectively, which were better than that of Ningnanmycin (256.35μg/mL) and Ribavirin (523.34μg/mL).
Atlanta, United States. In Gastroenterol Rep (oxf), Aug 2015
Gastrin is an important hormone of the digestive system, which assists gastric acid secretion.
Autoantibody to the gastrin receptor in pernicious anemia.
In N Engl J Med, 1985
We examined serum IgG fractions from 20 patients with pernicious anemia and 25 control subjects for their capacity to inhibit binding of [125I]15-leu human gastrin-17 to parietal-cell-enriched gastric mucosal cells.