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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Gastrin

Gastrin, gastrin-17, G17
Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cholecystokinin, ACID, HAD, Bombesin, somatostatin
Papers using Gastrin antibodies
Gastrin increases mcl-1 expression in type I gastric carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2 receptor
Supplier
Varro A. et al., In American Journal of Physiology - Gastrointestinal and Liver Physiology, 2005
... wortmannin were all from Calbiochem (Nottingham, UK), YM022 was from Tocris Bioscience (Bristol, UK), and gastrin-17 was from Bachem (St ...
Papers on Gastrin
Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer.
New
Smith et al., Columbia, United States. In Nucl Med Biol, 30 Apr 2014
UNLABELLED: Gastrin-releasing peptide receptors (GRPr) and prostate-specific membrane antigen (PSMA) are two identifying biomarkers expressed in very high numbers on prostate cancer cells and could serve as a useful tool for molecular targeting and diagnosis of disease via positron-emission tomography (PET).
Synthesis, in vitro and in vivo Evaluation of SiFA-tagged Bombesin and RGD Peptides as Tumor Imaging Probes for Positron Emission Tomography (PET).
New
Wängler et al., In Bioconjug Chem, 25 Apr 2014
UNLABELLED: Gastrin-releasing-peptide (GRP)-receptors and αvβ3-integrins are widely discussed as potential target structures for oncological imaging with positron emission tomography (PET).
GastroPanel® test for non-invasive diagnosis of atrophic gastritis in patients with dyspepsia.
New
Testoni et al., Milano, Italy. In Minerva Gastroenterol Dietol, 31 Mar 2014
Considering this limitation, a test named GastroPanel®, that measures the blood concentrations of pepsinogen I and II, gastrin-17 and H. pylori antibodies, has been developed as a potential non-invasive biopsy.
Engineered Insulin Secretion from Neuroendocrine Cells Isolated From Human Thyroid.
New
Weber et al., Decatur, United States. In World J Surg, 19 Mar 2014
Gastrin-releasing peptide (GRP) in conditioned medium and cell lysates was determined by reverse transcription (RT)-PCR, ELISA, and immunohistochemistry. RESULTS: Isolation yielded an average of 2.2 × 10(6) cells/g thyroid tissue, which stained for calcitonin/calcitonin gene-related protein, expressed genes consistent with NE origins, and secreted GRP.
Gastrin-releasing peptide receptor expression in lung cancer.
New
Schwartsmann et al., Porto Alegre, Brazil. In Arch Pathol Lab Med, Jan 2014
CONTEXT: Gastrin-releasing peptide receptors (GRPRs) activate mitogen-activated protein kinase signaling pathway primarily through epidermal growth factor receptor activation and are under investigation as a molecular target because they are overexpressed in several solid tumors.
Targeting GRPR in urological cancers--from basic research to clinical application.
Review
New
Reubi et al., Freiburg, Germany. In Nat Rev Urol, Apr 2013
Gastrin releasing peptide (GRP) is a regulatory peptide that acts through its receptor (GRPR) to regulate physiological functions in various organs.
Extraintestinal roles of bombesin-like peptides and their receptors: lung.
Review
New
Qu et al., Changsha, China. In Curr Opin Endocrinol Diabetes Obes, Feb 2013
RECENT FINDINGS: Gastrin-releasing peptide (GRP) was involved in the airway inflammation in murine models of airway hyperreactivity.
Luciferase assay to screen tumour-specific promoters in lung cancer.
Xu et al., Quanzhou, China. In Asian Pac J Cancer Prev, 2012
The activity and specificity of seven promoters, comprising CEACAM5 (carcinoembryonic antigen, CEA), GRP (Gastrin-Releasing Peptide), KRT19 (cytokeratin 19, KRT), SFTPB (surfactant protein B, SP-B), SERPINB3 (Squamous Cell Carcinoma Antigen, SCCA), SELP (Selectin P, Granule Membrane Protein 140 kDa, Antigen CD62, GMP) and DKK1 (Dickkopf-1) promoters were compared in lung cancer cells to obtain cancer-specific examples with strong activity.
Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).
GeneRIF
Patel et al., Melbourne, Australia. In Endocrinology, 2012
hypoxia up-regulates the gastrin gene in AGS cells by HIF-independent mechanisms
A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.
GeneRIF
Seva et al., Toulouse, France. In Cancer Prev Res (phila), 2012
progastrin predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps
Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma.
GeneRIF
Morii et al., China. In J Zhejiang Univ Sci B, 2012
a high level of PBX2 is a poor prognosticator for disease-free survival and overall survival in gingival squamous cell carcinoma
Immunohistochemical identification and localisation of gastrin and somatostatin in endocrine cells of human pyloric gastric mucosa.
GeneRIF
Lewandowska et al., Białystok, Poland. In Folia Morphol (warsz), 2012
Investigation of the healthy human pylorus shows characteristic distribution of cells that react with antisera to gastrin and somatostatin.
Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers.
Review
Sung et al., Stockholm, Sweden. In Scand J Gastroenterol, 2012
The fasting level of gastrin-17 is high in AG limited to the corpus and fundus, but low or non-elevated if the AG occurs in both antrum and corpus.
Serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy.
GeneRIF
Wasilewska et al., Białystok, Poland. In Adv Med Sci, 2010
analysis of serum gastrin concentrations in children with primary gastroesophageal reflux and gastroesophageal reflux secondary to cow's milk allergy
Gastrin-releasing peptide links stressor to cancer progression.
Review
Li et al., Xi'an, China. In J Cancer Res Clin Oncol, 2010
INTRODUCTION: Gastrin-releasing peptide (GRP) plays an important role in cancer growth and metastasis; however, the mechanisms of how GRP affects cancer progression are not well understood.
The production and role of gastrin-17 and gastrin-17-gly in gastrointestinal cancers.
Review
Lovas et al., Omaha, United States. In Protein Pept Lett, 2008
Additionally, gastrin has been suspected to play a role in the formation and growth of cancers of the colon, but recent studies have instead implicated gastrin processing intermediates, such as gastrin-17-Gly, acting upon a putative, non-cholecystokinin receptor.
Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer.
Impact
Caplin et al., London, United Kingdom. In J Clin Oncol, 2002
Gastrin acts as a growth factor for pancreatic cancer.
Autoantibody to the gastrin receptor in pernicious anemia.
Impact
Toh et al., In N Engl J Med, 1985
We examined serum IgG fractions from 20 patients with pernicious anemia and 25 control subjects for their capacity to inhibit binding of [125I]15-leu human gastrin-17 to parietal-cell-enriched gastric mucosal cells.
Phosphorylation of gastrin-17 by epidermal growth factor-stimulated tyrosine kinase.
Impact
Monckton et al., In Nature, 1983
Such a sequence is also found adjacent to the phosphotyrosine of middle T antigen, and in the homologous region of the hormone gastrin, adjacent to a tyrosine which is sulphated in approximately half the gastrin isolated from gastric mucosa.
Evidence for coexistence of dopamine and CCK in meso-limbic neurones.
Impact
Markey et al., In Nature, 1980
In the CNS, true gastrin molecules, gastrin-17 and gastrin-34 have been located only in the neurohypophysis, hypothalamus and occasionally in the medulla oblongata (unpublished results).
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