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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Gastrin-releasing peptide receptor

gastrin-releasing peptide receptor, GRPR, bombesin receptor
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Bombesin, Gastrin, ACID, CAN, HAD
Papers on gastrin-releasing peptide receptor
Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells.
New
Roesler et al., Porto Alegre, Brazil. In Mol Neurobiol, Feb 2016
The activation of gastrin-releasing peptide receptors (GRPR) stimulates GBM cell proliferation, whereas GRPR antagonists induce antiproliferative effects in in vitro and in vivo experimental models of GBM.
A Stress-related Peptide Bombesin Centrally Induces Frequent Urination through Brain Bombesin Receptor Types 1 and 2 in the Rat.
New
Saito et al., Kōchi, Japan. In J Pharmacol Exp Ther, Feb 2016
Bombesin-like peptides and bombesin receptor type 1 and 2 (BB1/BB2) in the brain have been implicated in the mediation/integration of stress responses.
Novel bispecific PSMA/GRPr targeting radioligands with optimized pharmacokinetics for improved PET imaging of prostate cancer.
New
Kopka et al., In Bioconjug Chem, Feb 2016
UNASSIGNED: A new series of bispecific radioligands targeting the prostate-specific membrane antigen (PSMA) and the gastrin releasing peptide receptor (GRPr), both expressed on prostate cancer cells, were developed.
In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies.
New
de Jong et al., Rotterdam, Netherlands. In Theranostics, Dec 2015
Gastrin-releasing peptide receptor (GRPR) targeting peptides are promising probes for a theranostic approach for PCa overexpressing GRPR.
New radiopharmaceutical agents for the treatment of castration-resistant prostate cancer.
Review
New
Chinol et al., Milano, Italy. In Q J Nucl Med Mol Imaging, Dec 2015
Gastrin-releasing peptide receptors (GRPr) are also highly overexpressed in PCa.
Gate control of mechanical itch by a subpopulation of spinal cord interneurons.
New
Impact
Goulding et al., Los Angeles, United States. In Science, Nov 2015
This chronic itch state is histamine-independent and is transmitted independently of neurons that express the gastrin-releasing peptide receptor.
Positron Emission Tomography in Prostate Cancer: Summary of Systematic Reviews and Meta-Analysis.
New
Jadvar, Los Angeles, United States. In Tomography, Sep 2015
Future systematic reviews will be needed for other emerging radiotracers such as those based on prostate specific membrane antigen and gastrin-releasing peptide receptor.
Molecular imaging of prostate cancer: translating molecular biology approaches into the clinical realm.
Review
New
Hricak et al., New York City, United States. In Eur Radiol, May 2015
• Other targets (e.g., PSA, prostate-stem cell antigen, GRPR) are in development.
Bombesin-like peptides and their receptors: recent findings in pharmacology and physiology.
Review
New
Qin et al., Changsha, China. In Curr Opin Endocrinol Diabetes Obes, Feb 2015
Both gastrin-releasing peptide receptor and neuromedin B receptor activation were shown to induce membrane depolarization and excite neurons in brain.
Gastrointestinal peptides and itch sensation.
Review
New
Weber, Boston, United States. In Curr Opin Endocrinol Diabetes Obes, Feb 2015
RECENT FINDINGS: GRP and its high-affinity GRP receptor (GRPR) have been identified as key regulators in the spinal cord itch pathway and may be involved in the maintenance of chronic itch sensation.
Bombesin receptor subtype 3 as a potential target for obesity and diabetes.
Review
Jensen et al., Madrid, Spain. In Expert Opin Ther Targets, 2014
It involves recognition of the central role the G-protein-coupled receptor, bombesin receptor subtype 3 (BRS-3) plays in energy/glucose metabolism.
Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility.
GeneRIF
Smith et al., Cambridge, United Kingdom. In J Physiol, 2012
Tonic stretch of human myometrium increases contractility and stimulates the expression of a known smooth muscle stimulatory agonist, GRP. GRP receptor antagonists attenuate the effect of stretch.
Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils.
GeneRIF
Bonorino et al., Porto Alegre, Brazil. In Proc Natl Acad Sci U S A, 2012
Gastrin-releasing peptide receptor mediates chemotaxis in neutrophils, and may be an alternative chemotactic receptor playing a role in the pathogenesis of inflammatory disorders.
Immunohistochemical analysis of gastrin-releasing peptide receptor (GRPR) and possible regulation by estrogen receptor βcx in human prostate carcinoma.
GeneRIF
Sasano et al., Sendai, Japan. In Neoplasma, 2011
High GRPR is associated with prostate carcinoma.
Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study.
GeneRIF
Siegfried et al., Pittsburgh, United States. In Respir Res, 2011
Bronchial gastrin-releasing peptide receptor expression was significantly associated with lung cancer in a multivariable logistic regression model adjusted for age, sex, smoking status and pulmonary function. Lung cancer risk was not modified by sex.
Murine GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex.
GeneRIF
Shumyatsky et al., United States. In Plos One, 2011
GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex
Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.
Impact
GeneRIF
Chen et al., Saint Louis, United States. In Cell, 2011
The data suggest that opioid-induced itch is an active process concomitant with but independent of opioid analgesia, occurring via the unidirectional cross-activation of GRPR signaling by MOR1D heterodimerization
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Impact
Reitman et al., Rahway, United States. In Cell Metab, 2010
Bombesin receptor subtype 3 (BRS-3) is a G protein coupled receptor whose natural ligand is unknown.
Cellular basis of itch sensation.
Impact
Chen et al., Saint Louis, United States. In Science, 2009
Although our previous study suggested that gastrin-releasing peptide receptor (GRPR) is an itch-specific gene in the spinal cord, a long-standing question of whether there are separate neuronal pathways for itch and pain remains unsettled.
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
Review
Impact
Benya et al., Bethesda, United States. In Pharmacol Rev, 2008
The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB(1)), the gastrin-releasing peptide (GRP) receptor (BB(2)), and the orphan receptor bombesin receptor subtype 3 (BRS-3) (BB(3)).
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