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Cholecystokinin B receptor

gastrin receptor
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gastrin, Cholecystokinin, ACID, HAD, CAN
Papers on gastrin receptor
Neural mechanism of gastric motility regulation by electroacupuncture at RN12 and BL21: A paraventricular hypothalamic nucleus-dorsal vagal complex-vagus nerve-gastric channel pathway.
New
He et al., Hefei, China. In World J Gastroenterol, Jan 2016
The expression levels of c-fos, motilin (MTL) and gastrin (GAS) in the paraventricular hypothalamic nucleus (PVN) were assayed by immunohistochemistry, and the expression levels of motilin receptor (MTL-R) and gastrin receptor (GAS-R) in both the PVN and the gastric antrum were assayed by western blotting.
The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion.
New
Yang et al., Beijing, China. In Plos One, Dec 2015
Renal dopamine D1-like receptors (D1R and D5R) and the gastrin receptor (CCKBR) are involved in the maintenance of sodium homeostasis.
Immunohistochemical examination of cholecystokinin and gastrin receptors (CCK-2/gastrin-R) expression in normal and exocrine cancerous human pancreatic tissues.
New
Moulessehoul et al., Sidi Bel Abbès, Algeria. In Pancreatology, Nov 2015
OBJECTIVE: Evaluating tissue samples of normal and exocrine cancerous human pancreas on the expression of CCK2/gastrin receptor.
Stereochemistry of amino acid spacers determines the pharmacokinetics of (111)In-DOTA-minigastrin analogues for targeting the CCK2/gastrin receptor.
New
Mansi et al., Ljubljana, Slovenia. In Bioconjug Chem, Jul 2015
The metabolic instability and high kidney retention of minigastrin (MG) analogues hamper their suitability for use in peptide-receptor radionuclide therapy of CCK2/gastrin receptor-expressing tumors.
Changes in FABP1 and gastrin receptor expression in the testes of rats that have undergone electrical injury.
New
Liu et al., Dali, China. In Exp Ther Med, Jun 2015
The aim of this study was to investigate alterations in the levels of fatty acid-binding protein 1 (FABP1) and gastrin receptor (gastrin R) in the testes following electrical injury.
LB02.04: GASTRIN AND D1 DOPAMINE RECEPTOR INTERACT TO INDUCE NATRIURESIS AND DIURESIS.
New
Jose et al., Baltimore, United States. In J Hypertens, Jun 2015
RESULTS: Gastrin infusing WKY rats via renal artery induced natriuresis and diuresis, which was blocked in the presence of CI-988, a gastrin receptor blocker.
The regulation of gastric acid secretion - clinical perspectives.
Review
Fossmark et al., Trondheim, Norway. In Acta Physiol (oxf), 2014
The gastrin receptor is localized to the ECL cell only, where gastrin stimulates the function and growth.
[Effects of Jiaweisinisan dispersion on content and gene expression of gastric tissue GASR and jejunal tissue VIPR2 of physical and mental stress model rat].
Xiong et al., Enshi, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2013
OBJECTIVE: To observe the effects of Jiaweisini dispersion (JWSNS) on the ultrastructure of gastric mucosa, the content and gene expression of gastric antrum tissue gastrin receptor (GASR) and jejunal tissue vasoactive intestinal peptide receptor 2 (VIPR2) in chronic stress gastric ulcer rats, and to elucidate its mechanism.
(68)Ga-Labeled DOTA-conjugated sCCK8[Phe(2)(p-CH2SO3H),Nle(3,6)], a sulfated cholecystokinin 8 (sCCK8) peptide derivative
Review
Chopra, Bethesda, United States. In Unknown Journal, 2013
CCK2R (previously known as CCKB, also designated as the gastrin receptor (GR)) is expressed in the brain, stomach, pancreas, and gallbladder and exhibits an almost equivalent affinity for gastrin and sulfated or non-sulfated CCK.
(111)In-Labeled DOTA-conjugated sCCK8[Phe(2)(p-CH2SO3H),Nle(3,6)], a sulfated cholecystokinin 8 (sCCK8) peptide derivative
Review
Chopra, Bethesda, United States. In Unknown Journal, 2013
CCK2R (previously known as CCKB, also designated as the gastrin receptor (GR)) is expressed in the brain, stomach, pancreas, and gallbladder and exhibits an almost equivalent affinity for gastrin and sulfated or non-sulfated CCK.
Gastric and duodenal neuroendocrine tumours.
Review
Jensen et al., Dublin, Ireland. In Best Pract Res Clin Gastroenterol, 2012
Other potential therapies such as somatostatin analogues and gastrin receptor antagonists may offer newer therapeutic possibilities.
Downregulation of the CCK-B receptor in pancreatic cancer cells blocks proliferation and promotes apoptosis.
GeneRIF
Smith et al., United States. In Am J Physiol Gastrointest Liver Physiol, 2012
These results show the importance of the CCK-BR in regulation of growth and apoptosis in pancreatic cancer.
Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes.
GeneRIF
Barber et al., Indianapolis, United States. In Mol Cancer Res, 2012
Data suggest that mutations in cholecystokinin 2 receptor (CCK2R) may promote tumorigenesis through deregulated receptor activity and highlight the importance of evaluating CCK2R inhibitors to block both the normal and mutant forms of the receptor.
(111)In/(68)Ga-Labeled DOTA conjugated cyclo[γ-d-Glu-Ala-Tyr-d-Lys]-Trp-Nle-Asp-Phe-NH2 (cyclo-MG2), a minigastrin analog
Review
Chopra, Bethesda, United States. In Unknown Journal, 2012
The CCK2R (previously known as CCKB) is expressed in the brain, stomach, pancreas and the gallbladder and exhibits an almost equivalent affinity for gastrin and sulfated or non-sulfated CCK (the CCK2R is also known as the gastrin receptor (GR)).
Characterization of a novel five-transmembrane domain cholecystokinin-2 receptor splice variant identified in human tumors.
GeneRIF
Fourmy et al., Toulouse, France. In Mol Cell Endocrinol, 2012
A novel splice variant acting as a dominant negative on membrane density of the CCK2R may be of importance for the pathophysiology of certain tumors and for their in vivo CCK2R-targeting.
A single nucleotide polymorphism of the cholecystokinin-B receptor predicts risk for pancreatic cancer.
GeneRIF
Phillips et al., Penn Hills, United States. In Cancer Biol Ther, 2012
A single nucleotide polymorphism in the cholecystokinin-B receptor that alters splicing predicts survival in pancreatic cancer.
Menin and JunD regulate gastrin gene expression through proximal DNA elements.
GeneRIF
Merchant et al., Ann Arbor, United States. In Am J Physiol Gastrointest Liver Physiol, 2011
proximal DNA elements within the human gastrin gene promoter mediate interactions between JunD, which induces gastrin gene expression and menin, which suppresses JunD-mediated activation.
Impaired gastric acidification negatively affects calcium homeostasis and bone mass.
Impact
Amling et al., Hamburg, Germany. In Nat Med, 2009
Mice deficient in Cckbr, encoding a gastrin receptor that affects acid secretion by parietal cells, have the expected defects in gastric acidification but also secondary hyperparathyroidism and osteoporosis and modest hypocalcemia.
A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists.
Impact
Kopin et al., Boston, United States. In Nature, 1993
The brain cholecystokinin-B/gastrin receptor (CCK-B/gastrin) has been implicated in mediating anxiety, panic attacks, satiety, and the perception of pain.
Autoantibody to the gastrin receptor in pernicious anemia.
Impact
Toh et al., In N Engl J Med, 1985
These results suggest that serum IgG from some patients with pernicious anemia contains autoantibodies to the gastrin receptor.
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