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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Growth arrest specific 7

GAS7, Gas7-cb, hGas7
Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, TMCO1, AGE, MLL, p53
Papers on GAS7
Growth-Arrest-Specific 7 Gene Regulates Neural Crest Formation and Craniofacial Development in Zebrafish.
Chao et al., Anyang, China. In Stem Cells Dev, Jan 2016
Growth-arrest-specific 7 (Gas7) is preferentially expressed in the nervous system and plays an important role during neuritogenesis in vertebrates.
A Genetic Variant in TGFBR3-CDC7 Is Associated with Visual Field Progression in Primary Open-Angle Glaucoma Patients from Singapore.
Vithana et al., Singapore, Singapore. In Ophthalmology, Dec 2015
Single nucleotide polymorphisms (SNPs) and their proxies from 10 POAG-associated loci (CAV1-CAV2, CDKN2B-AS1, SIX1-SIX6, an intergenic region on chromosome 8q22, ABCA1, GAS7, AFAP1, GMDS, PMM2, and TGFBR3-CDC7) identified from genome-wide association studies were tested for association with VF progression using logistic regression with an additive genetic model adjusting for age, gender, average intraocular pressure (IOP), central corneal thickness (CCT), and baseline vertical cup-to-disc ratio (VCDR).
New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis.
Larue et al., Orsay, France. In Cell Rep, Nov 2015
About 90% of the melanoma signature genes belong to an intrinsic network of transcription factors governing neural development (TFAP2A, DLX2, ALX1, MITF, PAX3, SOX10, LEF1, and GAS7) and miRNAs (211-5p, 221-3p, and 10a-5p).
Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer.
Wang et al., Taiwan. In Oncotarget, Nov 2015
UNASSIGNED: Growth-arrest-specific 7 (GAS7) belongs to a group of adaptor proteins that coordinate the actin cytoskeleton.
Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer.
Ponsa et al., Barcelona, Spain. In Carcinogenesis, Oct 2015
In addition, VCAN, FLT4, SFRP1 and GAS7 were also frequently involved in regions of UPD/UPP and displayed high levels of methylation.
Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell.
Santoro et al., Denver, United States. In Reprod Sci, Oct 2015
Comparative analysis of gene expression profiles by supervised clustering between group 1 versus group 2 resulted in the selection of 7 differentially expressed genes: fibroblast growth factor 12 (FGF-12), protein phosphatase 1-like (PPM1L), zinc finger protein multitype 2 (ZFPM2), forkhead box M1 (FOXM1), cell division cycle 20 (CDC20), interleukin 1 receptor-like 1 (IL1RL1), and growth arrest-specific protein 7 (GAS7).
ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure.
MacGregor et al., Hobart, Australia. In Hum Mol Genet, Jun 2015
Genes found to date associated with IOP and POAG are ABCA1, CAV1/CAV2, GAS7 and TMCO1.
Exome array analysis identifies CAV1/CAV2 as a susceptibility locus for intraocular pressure.
Duggal et al., Baltimore, United States. In Invest Ophthalmol Vis Sci, 2015
We successfully replicated the associations with GAS7 (P = 7.4 × 10(-3)) for IOP, and also identified a previously reported POAG locus in the CAV1/CAV2 region to be associated with IOP (P = 3.3 × 10(-3)).
DNA methylation profiles and biomarkers of oral squamous cell carcinoma.
Tai et al., Taiwan. In Epigenetics, 2014
Methylation of 7 genes (ASCL1, FGF3, FLT4, GAS7, KDR, TERT, and TFPI2) constitutes the top-20 panels for detecting OSCC.
An Updated Review on the Genetics of Primary Open Angle Glaucoma.
Chalam et al., Riyadh, Saudi Arabia. In Int J Mol Sci, 2014
Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) at different loci including CAV1/CAV2, TMCO1, CDKN2B-AS1, CDC7-TGFBR3, SIX1/SIX6, GAS7 and ATOH7 to be associated with POAG and its related quantitative traits (endophenotypes).
Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids.
Tsang et al., Bonn, Germany. In J Ovarian Res, 2014
RESULTS: A total of 573 gene transcripts, including CPA1, CDH1, INSL3, AMH, ALDH1B1, INHBA, CYP17A1, RBP4, GAS6, GAS7 and GATA4, were activated while 430 others including HSD17B7, HSD3B6, STAR, HMGCS1, HMGCR, CYP51, CYP11A1 and CYP19A1 were repressed in DHT-treated ovaries.
The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology.
Bergen et al., Amsterdam, Netherlands. In Prog Retin Eye Res, 2013
Recent Genome Wide Association Studies (GWAS) identified a large number of new POAG loci and disease genes, such as CAV1, CDKN2B and GAS7.
The genetics of intraocular pressure.
Pasquale et al., Boston, United States. In Semin Ophthalmol, 2013
More recently, genome-wide association studies (GWAS) have shown that common genetic variants in the GAS7 and TMCO1 genomic regions are associated with elevated IOP.
Common genetic determinants of intraocular pressure and primary open-angle glaucoma.
van Duijn et al., Rotterdam, Netherlands. In Plos Genet, 2011
Intraocular pressure (IOP)was significantly associated with rs11656696, located in GAS7 at 17p13.1 and with rs7555523, located in TMCO1 at 1q24.1.These data suggest that we have identified two clinically relevant genes involved in IOP regulation.
Gas7 mediates the differentiation of human bone marrow-derived mesenchymal stem cells into functional osteoblasts by enhancing Runx2-dependent gene expression.
Chao et al., Anyang, China. In J Orthop Res, 2011
regulates the differentiation of mesenchymal stem cells into osteoblasts by enhancing Runx2-dependent gene expression
Knockdown of growth-arrest-specific gene 7b (gas7b) using short-hairpin RNA desensitizes neuroblastoma cells to cisplatin: Implications for preventing apoptosis of neurons.
Chao et al., Anyang, China. In J Neurosci Res, 2010
Knockdown of Gas7 by shRNA preferentially suppressed the Gas7b protein isoform in human preneuronal cells and to reduce apoptosis induced either by serum starvation or by the antineoplastic agents in human neuroblastoma SH-SY5Y cells.
Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons.
Lin-Chao et al., Taipei, Taiwan. In J Biol Chem, 2010
Gas7 works through its interaction with N-WASP during neuronal maturation/ differentiation
A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.
Uchida et al., Sendai, Japan. In J Biol Chem, 2009
hGas7b has a role in microtubular maintenance and is possibly implicated in Alzheimer disease
Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias.
Cleary et al., Stanford, United States. In Cancer Cell, 2003
Here we demonstrate an alternative mechanism for activation of MLL following fusions with proteins (AF1p/Eps15 and GAS7) that normally reside in the cytoplasm.
MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice.
Cleary et al., Stanford, United States. In Cancer Cell, 2003
We demonstrate here that a representative MLL fusion protein, MLL-GAS7, impairs the differentiation and enhances the in vitro growth of murine hematopoietic cells with multipotent features.
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