Whole-genome cartography of p53 response elements ranked on transactivation potential.
Trento, Italy. In Bmc Genomics, 2014
Based on the mapping of predicted functional REs near TSS, we examined expression changes of thirteen genes as a function of different p53-inducing conditions, providing further evidence for PDE2A, GAS6, E2F7, APOBEC3H, KCTD1, TRIM32, DICER, HRAS, KITLG and TGFA p53-dependent regulation, while MAP2K3, DNAJA1 and potentially YAP1 were identified as new direct p53 target genes.
TAM receptor signaling in immune homeostasis.
In Annu Rev Immunol, 2014
The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation.
AXL kinase as a novel target for cancer therapy.
Guangzhou, China. In Oncotarget, 2014
The AXL receptor tyrosine kinase and its major ligand, GAS6 have been demonstrated to be overexpressed and activated in many human cancers (such as lung, breast, and pancreatic cancer) and have been correlated with poor prognosis, promotion of increased invasiveness/metastasis, the EMT phenotype and drug resistance.
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA.
Cambridge, United Kingdom. In Nature, 2013
These included an activating mutation in PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) following treatment with paclitaxel; a truncating mutation in RB1 (retinoblastoma 1) following treatment with cisplatin; a truncating mutation in MED1 (mediator complex subunit 1) following treatment with tamoxifen and trastuzumab, and following subsequent treatment with lapatinib, a splicing mutation in GAS6 (growth arrest-specific 6) in the same patient; and a resistance-conferring mutation in EGFR (epidermal growth factor receptor; T790M) following treatment with gefitinib.
Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer.
Ann Arbor, United States. In Mol Cancer Res, 2012
Data show that growth arrest-specific 6 (GAS6) and receptor tyrosine kinase Axl is colocalize with hypoxia-inducible factor-1alpha (Hif-1alpha) in both primary tumors and bone metastasis in prostate tumor tissue microarrays samples.