Sp1 and Sp3 regulate transcription of the chicken GAS41 gene.
Celle, Germany. In Biochim Biophys Acta, 2010
Mapping by a technique of indirect end labeling demonstrated that the Sp1-binding sites contained in this region exactly co-map with two previously identified DNase I hypersensitive (HS) sites, which suggests the important role of Sp1 binding in maintaining an open chromatin structure of the GAS41 promoter.
A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in glioma.
Homburg, Germany. In Mol Cancer Res, 2008
Expression analysis of the amplified region revealed 10 overexpressed genes (i.e., KUB3, CTDSP2, CDK4, OS-9, DCTN2, RAB3IP, FRS2, GAS41, MDM2, and RAP1B) that were consistently overexpressed in all cases that carried this amplification.