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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Growth arrest specific 2

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Actin, V1a, CAN, HAD, CHOP
Papers on Gas2
GAS2-Calpain2 axis contributes to the growth of leukemic cells.
Zhao et al., Suzhou, China. In Acta Biochim Biophys Sin (shanghai), Oct 2015
Growth arrest specific 2 (GAS2) modulates cell cycle, apoptosis, and Calpain activity.
Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.
Chan et al., Hong Kong, Hong Kong. In J Pathol, Sep 2015
Genome-wide scanning analysis and PCR validation identified growth arrest-specific 2 (GAS2) as a direct target of HBxΔ35 at transcriptional level in human immortalized liver cells.
GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.
Ballestrem et al., Manchester, United Kingdom. In J Cell Sci, 2014
By using fluorescence microscopy, we demonstrate that three members of this family, GAS2-like 1, GAS2-like 2 and GAS2-like 3 (G2L1, G2L2 and G2L3, also known as GAS2L1, GAS2L2 and GAS2L3, respectively) are differentially involved in mediating the crosstalk between F-actin and MTs.
Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants.
Middelberg et al., Australia. In Biotechnol Bioeng, 2014
The antigens studied were three heterologous N-terminal peptides (GAS1, GAS2, and GAS3) from the GAS surface M-protein that are specific to endemic strains in Australia Northern Territory Aboriginal communities.
Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth.
Zhao et al., Suzhou, China. In Plos One, 2013
Growth arrest specific 2 (GAS2) regulates multiple cellular functions including cell cycle, apoptosis and calpain activities.
The actin-microtubule cross-linking activity of Drosophila Short stop is regulated by intramolecular inhibition.
Rogers et al., Chapel Hill, United States. In Mol Biol Cell, 2013
In its inactive conformation, Shot adopts a "closed" conformation through interactions between its NH(2)-terminal actin-binding domain and COOH-terminal EF-hand-GAS2 domain.
Complexity of roles and regulation of the PMK1-MAPK pathway in mycelium development, conidiation and appressorium formation in Magnaporthe oryzae.
Dong et al., Hangzhou, China. In Gene Expr Patterns, 2013
MST50, MST11, MST7, PMK1 and GAS1/GAS2 genes are the important components in the PMK1-MAPK signal transduction pathway in fungi.
Molecular regulation of Trypanosoma congolense-induced nitric oxide production in macrophages.
Uzonna et al., Winnipeg, Canada. In Plos One, 2012
We further show that T. congolense induces differential iNOS transcriptional promoter activation in IFN-γ-primed cells, which is dependent on the activation of both GAS1 and GAS2 transcription factors in BALB.BM but only on GAS1 in ANA-1 cells.
GAS2L3, a target gene of the DREAM complex, is required for proper cytokinesis and genomic stability.
Gaubatz et al., Würzburg, Germany. In J Cell Sci, 2012
In this study, we characterized GAS2L3, which belongs to the GAS2 family of proteins with putative actin- and microtubule-binding domains as a target gene of DREAM.
Deciphering the transcriptional-regulatory network of flocculation in Schizosaccharomyces pombe.
Chua et al., Calgary, Canada. In Plos Genet, 2011
In contrast, the mild flocculation of adn2(+) or adn3(+) overexpression was likely mediated by the transcriptional activation of cell wall-remodeling genes including gas2(+), psu1(+), and SPAC4H3.03c.
Characterization of G2L3 (GAS2-like 3), a new microtubule- and actin-binding protein related to spectraplakins.
Ballestrem et al., Manchester, United Kingdom. In J Biol Chem, 2011
We identified a new member of the GAS2 family of MT-actin cross-linking proteins, named G2L3 (GAS2-like 3).
Expression, stability, and replacement of glucan-remodeling enzymes during developmental transitions in Saccharomyces cerevisiae.
Popolo et al., Milano, Italy. In Mol Biol Cell, 2011
GAS1 and GAS5 are expressed in vegetative cells and repressed during sporulation while GAS2 and GAS4 exhibit a reciprocal pattern.
Transcriptional profiling of cecal gene expression in probiotic- and Salmonella-challenged neonatal chicks.
Porter et al., College Park, United States. In Poult Sci, 2011
Based on this analysis, probiotic-induced differential regulation of the genes growth arrest-specific 2 (GAS2) and cysteine-rich, angiogenic inducer, 61 (CYR61) may result in increased apoptosis in the cecae of chicks.
Growth-arrest-specific protein 2 inhibits cell division in Xenopus embryos.
Mandato et al., Montréal, Canada. In Plos One, 2010
Furthermore, serum stimulation of quiescent, non-dividing cells leads to the down-regulation of gas2 and results in re-entry into the cell cycle.
Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription.
Eklund et al., Chicago, United States. In Mol Cell Biol, 2010
Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia.
β(1,3)-glucanosyl-transferase activity is essential for cell wall integrity and viability of Schizosaccharomyces pombe.
Vázquez de Aldana et al., Salamanca, Spain. In Plos One, 2009
Four genes encoding β(1,3)-glucanosyl-transferases -gas1(+), gas2(+), gas4(+) and gas5(+)- are present in S. pombe, although their function has not been analyzed.
Molecular mechanisms of yeast cell wall glucan remodeling.
van Aalten et al., Dundee, United Kingdom. In J Biol Chem, 2009
crystal structure of a glucan transglycosylase, Saccharomyces cerevisiae Gas2 (ScGas2), revealing a multidomain fold, with a (betaalpha)(8) catalytic core and a separate glucan binding domain with an elongated, conserved glucan binding groove.
The calpain system is involved in the constitutive regulation of beta-catenin signaling functions.
Schneider et al., Trieste, Italy. In J Biol Chem, 2005
Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin
Growth arrest-specific 2 gene expression during patellar tendon healing.
Chow et al., Hong Kong, Hong Kong. In Cells Tissues Organs, 2002
GAS2 gene might play a role in regulating tenocyte proliferation during tendon healing.
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