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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

GTPase activating protein and VPS9 domains 1

GAPex-5, Rab5-activating protein 6, RAP6, RME-6
Papers on GAPex-5
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5.
GeneRIF
Saltiel et al., Ann Arbor, United States. In Mol Biol Cell, 2008
the TC10/GAPEX-5/Rab5 axis mediates insulin-stimulated production of PI(3)P, which regulates trafficking of Glut4 vesicles
GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor.
GeneRIF
Stahl et al., Saint Louis, United States. In J Biol Chem, 2007
EGF-stimulated receptor ubiquitination and trafficking are mediated via GAPex-5: GAPex-5-mediated EGFR ubiquitination is independent of Rab5 activation
Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.
Impact
GeneRIF
Saltiel et al., Ann Arbor, United States. In Cell Metab, 2007
Insulin recruits the CIP4/Gapex-5 complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 vesicles to translocate to the cell surface, where Glut4 docks and fuses to transport glucose into the cell.
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