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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

GTPase activating protein and VPS9 domains 1

GAPex-5, Rab5-activating protein 6, RAP6, RME-6
Top mentioned proteins: Rab5, GAP, Rab31, Insulin, Akt
Papers on GAPex-5
RAP-PCR fingerprinting reveals time-dependent expression of development-related genes following differentiation process of Bacillus thuringiensis.
Guan et al., Fuzhou, China. In Can J Microbiol, Sep 2015
Six differentially expressed transcripts (RAP1 to RAP6) were obtained.
The role of the small GTPase Rab31 in cancer.
Tang et al., Singapore, Singapore. In J Cell Mol Med, 2015
Rab31 and its guanine nucleotide exchange factor GAPex-5 have, however, also been shown to enhance early endosome-late endosome transport and degradation of the epidermal growth factor receptor (EGFR).
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5.
Saltiel et al., Ann Arbor, United States. In Mol Biol Cell, 2008
the TC10/GAPEX-5/Rab5 axis mediates insulin-stimulated production of PI(3)P, which regulates trafficking of Glut4 vesicles
Imaging of Rab5 activity identifies essential regulators for phagosome maturation.
Matsuda et al., Kyoto, Japan. In Nature, 2008
Furthermore, we found that Gapex-5 is the guanine nucleotide exchange factor essential for Rab5 activation during the engulfment of apoptotic cells.
Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking.
Pessin et al., Stony Brook, United States. In Curr Opin Cell Biol, 2007
In addition, the VPS9 domain-containing protein Gapex-5 in complex with CIP4 appears to function as a Rab31 guanylnucleotide exchange factor that is necessary for insulin-stimulated GLUT4 translocation.
GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor.
Stahl et al., Saint Louis, United States. In J Biol Chem, 2007
EGF-stimulated receptor ubiquitination and trafficking are mediated via GAPex-5: GAPex-5-mediated EGFR ubiquitination is independent of Rab5 activation
Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.
Saltiel et al., Ann Arbor, United States. In Cell Metab, 2007
Insulin recruits the CIP4/Gapex-5 complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 vesicles to translocate to the cell surface, where Glut4 docks and fuses to transport glucose into the cell.
Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5.
Stahl et al., Saint Louis, United States. In J Biol Chem, 2006
Additional evidence supporting a role for Rab5 was suggested by studies with GAPex-5, a vps9 domain containing exchange factor.
Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis.
Barbieri et al., Miami, United States. In Biochem Biophys Res Commun, 2006
In this study, we report the identification of a new human Rab5 guanine nucleotide exchange factor (GEF), which we have named RAP6 (Rab5-activating protein 6).
Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit.
Grant et al., United States. In Nat Cell Biol, 2005
Here we identify a new regulator of endocytosis called RME-6.
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