Stopping ras in its tracks.
In PLoS ONE, 2006
... from Santa Cruz Biotechnology, mouse anti-phospho-ERK Ab from Sigma-Aldrich, and rabbit anti-phospho-Akt (ser473) and rabbit anti-glyceraldehyde-3-phosphate dehydrogenase (14C10) Abs from Cell Signaling Technology ...
Deciphering the mystery of hepatitis B virus receptors: A historical perspective.
Islamabad, Pakistan. In Virusdisease, Sep 2015
So far, several proteins have been proposed to interact with these different regions of the preS1 domain which includes human immunoglobulin A receptor, glyceraldehyde-3-phosphate dehydrogenase, interleukin-6, a 31-kDa protein, HBV binding factor, asialoglycoprotein receptor, nascent polypeptide-associated complex α polypeptide, lipoprotein lipase, hepatocyte-associated heparan sulfate proteoglycans, glucose-regulated protein 75.
Chalcone scaffolds as anti-infective agents: structural and molecular target perspectives.
Bilāspur, India. In Eur J Med Chem, Sep 2015
Several natural and (semi) synthetic chalcones deserve the credit of being potential anti-infective candidates that inhibit various parasitic, malarial, bacterial, viral, and fungal targets like cruzain-1/2, trypanopain-Tb, trans-sialidase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), fumarate reductase, falcipain-1/2, β-hematin, topoisomerase-II, plasmepsin-II, lactate dehydrogenase, protein kinases (Pfmrk and PfPK5), and sorbitol-induced hemolysis, DEN-1 NS3, H1N1, HIV (Integrase/Protease), protein tyrosine phosphatase A/B (Ptp-A/B), FtsZ, FAS-II, lactate/isocitrate dehydrogenase, NorA efflux pump, DNA gyrase, fatty acid synthase, chitin synthase, and β-(1,3)-glucan synthase.
Nitric Oxide-GAPDH Transcriptional Signaling Mediates Behavioral Actions of Cocaine.
Baltimore, United States. In Cns Neurol Disord Drug Targets, 2014
We describe a signaling system wherein lower behavioral stimulant doses of cocaine, as well as higher neurotoxic doses, activate a cascade wherein nitric oxide nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to generate a complex with the ubiquitin-E3-ligase Siah1 which translocates to the nucleus.
The chemical biology of naphthoquinones and its environmental implications.
Tsukuba, Japan. In Annu Rev Pharmacol Toxicol, 2011
The targets for these reactions include regulatory proteins such as protein tyrosine phosphatases; Kelch-like ECH-associated protein 1, the regulatory protein for NF-E2-related factor 2; and the glycolysis enzyme glyceraldehyde-3-phosphate dehydrogenase.