Constitutive expression and anticancer potency of a novel immunotoxin onconase-DV3.
Changchun, China. In Oncol Rep, Feb 2016
In the present study, we constructed a constitutive expression vector for onconase-(DV3)2 (Onc-DV3) production in yeast Pichia pastoris with the GAP promoter, in which the Onc-DV3 gene is inserted downstream of the truncated Saccharomyces cerevisiae α-mating factor-pre (α-MF-pre) secretion signal.
The complexity of the Nrf2 pathway: beyond the antioxidant response.
United States. In J Nutr Biochem, Dec 2015
The stability and cellular distribution of Nrf2 is tightly controlled by its inhibitory binding protein Kelch-like ECH-associated protein 1. Nrf2 signalling is also regulated by posttranslational, transcriptional, translational and epigenetic mechanisms, as well as by other protein partners, including p62, p21 and IQ motif-containing GTPase activating protein 1.
Challenges in the classification of fibrotic ILD.
Århus, Denmark. In Sarcoidosis Vasc Diffuse Lung Dis, 2014
However, the ILD-GAP index has recently been validated in this group and can risk-stratify patients based on four easily measurable variables.