Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons.
In PLoS ONE, 1987
... Vimentin (Abcam, Chemicon), Peripherin (Chemicon), FAK (N-20, Santa Cruz Biotechnology), Acetylated-Tubulin (Abcam), Tyrosinated Tubulin (Abcam), GAP-43 (Abcam), Neurofilament light chain (Chemicon, ...
Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients.
Kōbe, Japan. In Oncol Lett, Nov 2015
In the present study, the expression of 11 previously validated MRD markers (CHRNA3, CRMP1, DBH, DCX, DDC, GABRB3, GAP43, ISL1, KIF1A, PHOX2B and TH) was determined in 23 pairs of PB and BM samples collected from seven high-risk neuroblastoma patients at the same time point, and the sample was scored as MRD-positive if one of the MRD markers exceeded the normal range.
Cerebrospinal fluid analysis.
London, United Kingdom. In Handb Clin Neurol, 2013
Other biological molecules can also be found in the CSF including neurofiliment, myelin basic protein (MBP), glial fibrillary acidic protein (GFAP), tau, neuronal cell adhesion molecule (NCAM), and the growth associated protein (GAP-43).
[Progress of researches on mechanisms of acupuncture underlying improvement of depression in the past five years].
Beijing, China. In Zhen Ci Yan Jiu, 2013
In the present paper, the authors summarize mechanisms of acupuncture for depression from 1) upregulating levels of monoamine neurotransmitters, gamma-aminobutyric acid, 5-HT, receptor binding, and hypothalamic neuropeptide Y, beta-endorphine, and mu-receptor expression, and down-regulating hippocampal glutamate content, etc.; 2) upregulating expression of hippocampal brain-derived neurotrophic factor protein and mRNA and its receptor TrkB, and activating adenyl cyclase-cAMP-PKA-CREB signaling pathway; 3) increasing hippocampal growth-associated protein 43 level and suppressing hippocampal c-Jun N-terminal kinase activation and cellular apoptosis; 4) upregulating expression of glial fibrillary acidic protein (activating glia cells); 5) regulating activities of hypothalamus-pituitary-adrenal axis and hypothalamus-pituitary-sex gland axis; 6) down-regulating serum IL-1beta, IL-6, and tumor necrosis factor-alpha levels.
Structural plasticity of climbing fibers and the growth-associated protein GAP-43.
Chicago, United States. In Front Neural Circuits, 2012
We reviewed the significant endogenous regenerative potential of the neurons of the inferior olive (IO) in the adult rodent brain and the structural remodeling of the terminal arbor of their axons, the climbing fiber (CF), under various experimental conditions, focusing on the growth-associated protein GAP-43.
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling.
Vienna, Austria. In Nat Cell Biol, 2001
Here we show that N-CAM modulates neurite outgrowth and matrix adhesion of beta-cells from pancreatic tumours by assembling a fibroblast-growth-factor receptor-4 (FGFR-4) signalling complex, which consists of N-cadherin, FGFR-4, phospholipase C gamma (PLC-gamma), the adaptor protein FRS2, pp60(c-src), cortactin and growth-associated protein-43 (GAP-43).
Bern, Switzerland. In Lancet, 1999
Since the content of neuropeptides seems to be altered in chronic inflammation, we investigated possible changes in peptidergic innervation for substance P (SP), vasoactive intestinal peptide (VIP), and growth-associated protein-43 (GAP-43).