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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Growth associated protein 43

GAP-43, growth-associated protein-43
may play a role in neurite outgrowth and nerve regeneration [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GAP, CAN, HAD, V1a, Synaptophysin
Papers using GAP-43 antibodies
Intermediate filaments are dynamic and motile elements of cellular architecture.
Pellman David, In PLoS Biology, 2003
... CFP-tagged RanBP2 fragments with the N-terminal palmitoylation signal derived from GAP-43 were generated in a modified version of the pECFP-N1 vector (Clontech) by a PCR based strategy ...
Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro.
Reh Thomas A., In PLoS ONE, 1992
... -GAP43-GFP)1Wbh transgenic mouse line (referred to ...
Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons.
Mei Lin, In PLoS ONE, 1987
... Vimentin (Abcam, Chemicon), Peripherin (Chemicon), FAK (N-20, Santa Cruz Biotechnology), Acetylated-Tubulin (Abcam), Tyrosinated Tubulin (Abcam), GAP-43 (Abcam), Neurofilament light chain (Chemicon, ...
Papers on GAP-43
(1)H, (15)N, (13)C resonance assignment of human GAP-43.
Coudevylle et al., Vienna, Austria. In Biomol Nmr Assign, Feb 2016
UNASSIGNED: GAP-43 is a 25 kDa neuronal intrinsically disordered protein, highly abundant in the neuronal growth cone during development and regeneration.
Altered Expression of Growth Associated Protein-43 and Rho Kinase in Human Patients with Parkinson's Disease.
Lingor et al., Göttingen, Germany. In Brain Pathol, Feb 2016
Investigation of the expression pattern of the regeneration-associated protein GAP-43 suggested a lower regenerative capacity in nigral dopaminergic neurons of PD patients.
Myostatin propeptide gene delivery by gene gun ameliorates muscle atrophy in a rat model of botulinum toxin-induced nerve denervation.
Chen et al., T'ai-chung-shih, Taiwan. In Life Sci, Feb 2016
And enhancement of the gene expression of the muscle regulatory factors, neurite outgrowth factors (IGF-1, GAP43) and acetylcholine receptors was observed.
Brain tumour cells interconnect to a functional and resistant network.
Winkler et al., Heidelberg, Germany. In Nature, Jan 2016
The resulting network allows multicellular communication through microtube-associated gap junctions.
Research Report: Intermittent hypobaric hypoxia and hyperbaric oxygen on GAP-43 in the rat carotid body.
Wang et al., In Undersea Hyperb Med, Nov 2015
Adaptive changes in the carotid body (CB) including the expression of the growth-associated protein-43 (GAP-43) have been studied in response to low, but not high, oxygen exposure.
Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients.
Nishimura et al., Kōbe, Japan. In Oncol Lett, Nov 2015
In the present study, the expression of 11 previously validated MRD markers (CHRNA3, CRMP1, DBH, DCX, DDC, GABRB3, GAP43, ISL1, KIF1A, PHOX2B and TH) was determined in 23 pairs of PB and BM samples collected from seven high-risk neuroblastoma patients at the same time point, and the sample was scored as MRD-positive if one of the MRD markers exceeded the normal range.
Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma.
Le et al., Dallas, United States. In Cancer Cell, 2014
Using cell-lineage tracing, we identify a population of GAP43(+) PLP(+) precursors in embryonic nerve roots as the cells of origin for these tumors and report a non-germline neurofibroma model for preclinical drug screening to identify effective therapies.
Cerebrospinal fluid analysis.
Giovannoni, London, United Kingdom. In Handb Clin Neurol, 2013
Other biological molecules can also be found in the CSF including neurofiliment, myelin basic protein (MBP), glial fibrillary acidic protein (GFAP), tau, neuronal cell adhesion molecule (NCAM), and the growth associated protein (GAP-43).
Far upstream element binding protein 1: a commander of transcription, translation and beyond.
Chen et al., Tucson, United States. In Oncogene, 2013
In recent years, mounting evidence suggests that FBP1 acts as an RNA-binding protein and regulates mRNA translation or stability of genes, such as GAP43, p27(Kip) and nucleophosmin.
[Progress of researches on mechanisms of acupuncture underlying improvement of depression in the past five years].
Tu et al., Beijing, China. In Zhen Ci Yan Jiu, 2013
In the present paper, the authors summarize mechanisms of acupuncture for depression from 1) upregulating levels of monoamine neurotransmitters, gamma-aminobutyric acid, 5-HT, receptor binding, and hypothalamic neuropeptide Y, beta-endorphine, and mu-receptor expression, and down-regulating hippocampal glutamate content, etc.; 2) upregulating expression of hippocampal brain-derived neurotrophic factor protein and mRNA and its receptor TrkB, and activating adenyl cyclase-cAMP-PKA-CREB signaling pathway; 3) increasing hippocampal growth-associated protein 43 level and suppressing hippocampal c-Jun N-terminal kinase activation and cellular apoptosis; 4) upregulating expression of glial fibrillary acidic protein (activating glia cells); 5) regulating activities of hypothalamus-pituitary-adrenal axis and hypothalamus-pituitary-sex gland axis; 6) down-regulating serum IL-1beta, IL-6, and tumor necrosis factor-alpha levels.
Molecular mechanisms of treadmill therapy on neuromuscular atrophy induced via botulinum toxin A.
Chen et al., T'ai-chung-shih, Taiwan. In Neural Plast, 2012
Treadmill training had no influence on gastrocnemius mass that received BoNT-A injection, but it improved the maximal contraction force of the gastrocnemius, and upregulation of GAP-43, IGF-1, Myo-D, Myf-5, myogenin, and acetylcholine receptor (AChR) subunits α and β was found following treadmill training.
Structural plasticity of climbing fibers and the growth-associated protein GAP-43.
Strata et al., Chicago, United States. In Front Neural Circuits, 2012
We reviewed the significant endogenous regenerative potential of the neurons of the inferior olive (IO) in the adult rodent brain and the structural remodeling of the terminal arbor of their axons, the climbing fiber (CF), under various experimental conditions, focusing on the growth-associated protein GAP-43.
Neonatal handling and environmental enrichment increase the expression of GAP-43 in the hippocampus and promote cognitive abilities in prenatally stressed rat offspring.
Chen et al., Guangzhou, China. In Neurosci Lett, 2012
further evidence to support a key role for GAP-43 in brain development.
Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus.
Bednarik et al., Brno, Czech Republic. In J Neurol Sci, 2012
Impaired regeneration of intra-epidermal C fibers in the early stages of type 2 diabetes mellitus, as indicated by GAP-43 expression, might be a marker of incipient diabetic neuropathy.
Depressed neuronal growth associated protein (GAP)-43 expression in the small intestines of mice experimentally infected with Neodiplostomum seoulense.
Shin et al., Seoul, South Korea. In Korean J Parasitol, 2012
GAP-43 expression in the mucosal myenteric plexus was markedly reduced in the small intestines of Neodiplostomum seoulense-infected mice.
Genetic and functional analysis of the gene encoding GAP-43 in schizophrenia.
Chen et al., Taiwan. In Schizophr Res, 2012
The results of this study supported to the hypothesis of multiple rare mutations in schizophrenia, and it provides genetic clues that indicate the involvement of GAP-43 in this disorder.
Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration.
Lichter et al., Heidelberg, Germany. In Plos Genet, 2011
Nos2 deficiency promotes medulloblastoma development in Ptch1(+/-) mice through retention of proliferating GCPs in the external granular layer due to reduced Gap43 expression
Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury.
Martin-Villalba et al., Heidelberg, Germany. In Nat Med, 2004
The improvement in locomotor performance was mirrored by an increase in regenerating fibers and upregulation of growth-associated protein-43 (GAP-43).
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling.
Christofori et al., Vienna, Austria. In Nat Cell Biol, 2001
Here we show that N-CAM modulates neurite outgrowth and matrix adhesion of beta-cells from pancreatic tumours by assembling a fibroblast-growth-factor receptor-4 (FGFR-4) signalling complex, which consists of N-cadherin, FGFR-4, phospholipase C gamma (PLC-gamma), the adaptor protein FRS2, pp60(c-src), cortactin and growth-associated protein-43 (GAP-43).
Neuroimmune appendicitis.
Büchler et al., Bern, Switzerland. In Lancet, 1999
Since the content of neuropeptides seems to be altered in chronic inflammation, we investigated possible changes in peptidergic innervation for substance P (SP), vasoactive intestinal peptide (VIP), and growth-associated protein-43 (GAP-43).
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