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Aldehyde dehydrogenase 9 family, member A1

gamma-trimethylaminobutyraldehyde dehydrogenase, 4-trimethylaminobutyraldehyde dehydrogenase, TMABA-DH
catalyzes the conversion of gamma-trimethylaminobutyraldehyde to gamma-butyrobetaine in carnitine biosynthesis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, PPAR, ACID, MAX
Papers on gamma-trimethylaminobutyraldehyde dehydrogenase
Molecular characterization and organ-specific expression of the gene that encodes betaine aldehyde dehydrogenase from the white shrimp Litopenaeus vannamei in response to osmotic stress.
New
Rosas-Rodríguez et al., Hermosillo, Mexico. In Comp Biochem Physiol B Biochem Mol Biol, Nov 2015
The amino acid sequence of LvBADH is related to that of other BADHs, TMABA-DH and ALDH9 from invertebrate and vertebrate homologues, and includes the essential domains of their function and regulation.
Identification of 4-Trimethylaminobutyraldehyde Dehydrogenase (TMABA-DH) as a Candidate Serum Autoantibody Target for Kawasaki Disease.
Hattori et al., Tokyo, Japan. In Plos One, 2014
We performed two-dimensional western blotting and LC-MS/MS to analyze the antigens of autoantibodies, detected two protein spots with 4 out of 24 sera from KD patients but not with 6 control sera, and identified the antigens as 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH).
Pharmacological doses of niacin stimulate the expression of genes involved in carnitine uptake and biosynthesis and improve the carnitine status of obese Zucker rats.
Eder et al., Gießen, Germany. In Bmc Pharmacol Toxicol, 2013
BACKGROUND: Activation of peroxisome proliferator-activated receptor (PPAR)α and PPARδ causes an elevation of tissue carnitine concentrations through induction of genes involved in carnitine uptake [novel organic cation transporter 2, (OCTN2)], and carnitine biosynthesis [γ-butyrobetaine dioxygenase (BBD), 4-N-trimethyl-aminobutyraldehyde dehydrogenase (TMABA-DH)].
The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor α.
Eder et al., Gießen, Germany. In Biochim Biophys Acta, 2012
Whether other genes encoding enzymes involved in the carnitine synthesis pathway, such as 4-N-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH) and trimethyllysine dioxygenase (TMLD), are also direct PPARα target genes is less clear.
Effects of fish oil and conjugated linoleic acids on carnitine homeostasis in laying hens.
Eder et al., Gießen, Germany. In Br Poult Sci, 2011
Diets with fish oil or CLA had only a weak effect on mRNA levels of PPARα target genes (ACO, CPT-I) in the liver and did not influence mRNA concentrations of the most important carnitine transporter OCTN2, enzymes of involved in carnitine synthesis (TMLD, TMABA-DH, BBD) or concentrations of carnitine in plasma, liver and total egg contents.
Ontogeny of Na(+)/L-carnitine transporter and of gamma-trimethylaminobutyraldehyde dehydrogenase and gamma-butyrobetaine hydroxylase genes expression in rat kidney.
GeneRIF
Ilundáin et al., Sevilla, Spain. In Mech Ageing Dev, 2009
Foetuses express TMABA-DH mRNA and this expression increased during postnatal life
Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.
Wanders et al., Amsterdam, Netherlands. In J Biol Chem, 2000
The penultimate step in carnitine biosynthesis is mediated by gamma-trimethylaminobutyraldehyde dehydrogenase (EC 1.2.1.47),
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