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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Synuclein, gamma

gamma-Synuclein, BCSG1, SNCG, synoretin
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, alpha-Synuclein, AGE, POLYMERASE
Papers on gamma-Synuclein
Exploring new biomarkers in the tumour microenvironment of canine inflammatory mammary tumours.
Argyle et al., Vila Real, Portugal. In Vet Comp Oncol, Feb 2016
Gene expression differences between CIMC and non-CIMC types were obtained for cyclooxygenase 2 (COX-2) (P = 0.004), synuclein gamma (SNCG) (P = 0.006), tribbles 1 (P = 0.025), vascular endothelial growth factor (VEGF) (P = 0.017) and CSF1R (P = 0.045).
Gene expression profiling of prostate cancer-associated genes identifies fibromodulin as potential novel biomarker for prostate cancer.
Reyes et al., Cartagena, Colombia. In Int J Biol Markers, Jan 2016
Genes evaluated were ESM-1, SERPINE2, CLU, BGN, A2M, PENK, FMOD, CD81, DCN, TSPAN8, KBTBD10, F2RL1, TMSB4X, SNCG, CXXC5, FOXQ1, PDPN, SPN, CAV1, CD24 and KLK3.
γ-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma.
Shieh et al., Taipei, Taiwan. In J Dent Res, Jan 2016
UNASSIGNED: Dysregulation of γ-synuclein (SNCG) has been reported in many cancers; however, its role in cancer development is still controversial.
Multipronged Approach to Identify and Validate a Novel Upstream Regulator of Sncg in Mouse Retinal Ganglion Cells.
Jablonski et al., Memphis, United States. In Febs J, Jan 2016
Recently, γ-synuclein (SNCG) has been shown to be highly expressed in the somas and axons of RGCs.
Alternative splicing of synuclein gamma in endometrial cancer: identification of a novel isoform.
Stickeler et al., Freiburg, Germany. In Oncotarget, Oct 2015
Synuclein gamma (SNCG) is under consideration as a potential biomarker in cancer biology.
Synuclein-γ promotes migration of MCF7 breast cancer cells by activating extracellular-signal regulated kinase pathway and breaking cell-cell junctions.
Shou et al., Beijing, China. In Mol Med Report, Sep 2015
Synuclein-γ (SNCG), a synuclein family member, promotes migration, invasion and metastasis of tumor cells; however, the mechanism remains unclear.
Unregulated long non-coding RNA-AK058003 promotes the proliferation, invasion and metastasis of breast cancer by regulating the expression levels of the γ-synuclein gene.
Wang et al., Jinan, China. In Exp Ther Med, May 2015
Bioinformatics analysis revealed that the γ-synuclein gene (SNCG) may be a target gene regulated by lncRNA-AK058003.
[Expressions of TUBB3 and γ-synuclein in colorectal adenocarcinoma and their clinical significance].
Zheng et al., Tianjin, China. In Zhonghua Yi Xue Za Zhi, May 2015
OBJECTIVE: To explore the expressions of TUBB3 (β-tubulin III) and γ-synuclein (SNCG) in colorectal adenocarcinoma and their clinical significance.
Combined expression of metastasis related markers Naa10p, SNCG and PRL-3 and its prognostic value in breast cancer patients.
Shou et al., Beijing, China. In Asian Pac J Cancer Prev, 2014
In this study, we evaluated the protein levels of N-α-acetyltransferase 10 protein (Naa10p), synuclein-γ (SNCG), and phosphatase of regenerating liver-3 (PRL-3) in 365 patients with breast cancer by immunohistochemistry. Distinct prognostic subgroups of breast cancer were identified by combination of the three biomarkers.
Inhibition of ACE Retards Tau Hyperphosphorylation and Signs of Neuronal Degeneration in Aged Rats Subjected to Chronic Mild Stress.
Quitterer et al., Zürich, Switzerland. In Biomed Res Int, 2014
Signs of neurodegeneration were detected by the significant downregulation of neuronal structure proteins such as microtubule-associated protein 2 (Map2) and synuclein-gamma (Sncg).
Predictive and prognostic values of BubR1 and synuclein-gamma expression in breast cancer.
Argon et al., İstanbul, Turkey. In Int J Clin Exp Pathol, 2014
The aim of this study is to determine the expression level of spindle assembly checkpoint (SAC) proteins-BubR1 and synuclein-gamma (SNCG) in human breast cancer tissues and to test whether there is a relationship between their expression levels and clinicopathologic parameters including respons to taxanes, tumor grade, estrogen receptor (ER) pozitivity, HER2 status, and overall survival (OS).
Differential staining of γ synuclein in poorly differentiated compared to highly differentiated colon cancer cells.
Melzer et al., Israel. In Oncol Rep, 2012
SNCG can serve as a marker for the potential of the tumor cell for the rapid spreading and metastazing of the non-differentiated tumors.
Combined phenotype of 4 markers improves prognostic value of patients with colon cancer.
Shou et al., Beijing, China. In Am J Med Sci, 2012
SNCG biomarker has independently poor prognostic value for patients with lymph node metastasis.
Synuclein-γ (SNCG) protein expression is associated with poor outcome in endometrial adenocarcinoma.
Odunsi et al., Buffalo, United States. In Gynecol Oncol, 2012
Overexpression of SNCG seemed to be a predictor biomarker for aggressive tumor behavior and adverse outcome in patients with endometrial cancer.
γ-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors.
Ratech et al., New York City, United States. In Am J Surg Pathol, 2011
gamma-synuclein is a promising new adjunct marker for identifying reactive follicular dendritic cells and for diagnosing follicular dendritic cell sarcoma and benign and malignant vascular tumors.
SNCG gene silencing in gallbladder cancer cells inhibits key tumorigenic activities.
Chen et al., Fuzhou, China. In Front Biosci, 2011
Data from our in vivo study showed a decrease in tumor growth and weight in mice injected with SNCG-silenced NOZ cells. Together, these findings suggest that SNCG plays an important role in the progression of GBC
[Role of genetics in the etiology of synucleinopathies].
de Pancorbo et al., Vitoria-Gasteiz, Spain. In Rev Esp Geriatr Gerontol, 2011
In general, the β-synuclein protein, codified by the SNCB gene, acts as a regulator of processes triggered by α-synuclein and its function is altered by variations in the gene sequence, while γ-synuclein, codified by the SNCG gene, seems to play a major role in certain tumoral processes.
Targeting synuclein-gamma to counteract drug resistance in cancer.
Jia et al., Kingston, Canada. In Expert Opin Ther Targets, 2008
BACKGROUND: Expression of synuclein-gamma (SNCG) protein is elevated in the advanced stages of many types of cancers, including ovarian, lung, liver, esophagus, colon, prostate and, in particular, breast.
Gamma-synuclein and the progression of cancer.
El-Agnaf et al., Al `Ayn, United Arab Emirates. In Faseb J, 2007
The synucleins are a small, soluble, highly conserved group of neuronal proteins that have been implicated in both neurodegenerative diseases and cancer.
Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.
Haass et al., München, Germany. In Ann N Y Acad Sci, 1999
Members of the family include alpha- and beta-SYN, and the more distantly related gamma-SYN and synoretin.
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