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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Gamma-glutamyl carboxylase

gamma-glutamyl carboxylase
catalyzes the posttranslational modification of glutamate to gamma-carboxyglutamate (Gla); may mediate functions of vitamin K-dependent proteins (VKDPs) [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, AGE, CYP2C9
Papers on gamma-glutamyl carboxylase
Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and non-bleeding disorders.
New
Stafford et al., Chapel Hill, United States. In Blood, Feb 2016
UNASSIGNED: Vitamin K-dependent coagulation factors deficiency (VKCFD) is a bleeding disorder mainly associated with mutations in gamma-glutamyl carboxylase (GGCX) that often has fatal outcomes.
Structural and functional insights into enzymes of the vitamin K cycle.
Review
New
Stafford et al., Chapel Hill, United States. In J Thromb Haemost, Jan 2016
The enzymes involved in the vitamin K-dependent carboxylation include: gamma-glutamyl carboxylase (GGCX), vitamin K epoxide reductase (VKOR), and an as-yet-unidentified vitamin K reductase (VKR).
Effects of NAD(P)H quinone oxidoreductase 1 polymorphisms on stable warfarin doses in Korean patients with mechanical cardiac valves.
New
Gwak et al., Seoul, South Korea. In Eur J Clin Pharmacol, Oct 2015
Also, genotypes of vitamin K epoxide reductase complex subunit 1 (VKORC1), cytochrome P450 (CYP) 2C9, CYP4F2, gamma-glutamyl carboxylase (GGCX), and GATA4 were determined.
Impact of polymorphisms of the GGCX gene on maintenance warfarin dose in Chinese populations: Systematic review and meta-analysis.
Review
New
Shen et al., Fuzhou, China. In Meta Gene, Sep 2015
The meta-analysis was conducted to investigate the impact of gamma-glutamyl carboxylase (GGCX) on maintenance warfarin dose.
Impact of gamma-glutamyl carboxylase gene polymorphisms on warfarin dose requirement: a systematic review and meta-analysis.
Review
New
Chen et al., China. In Thromb Res, Apr 2015
BACKGROUND: The Gamma-glutamyl carboxylase (GGCX) gene, as with Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1), CytochromeP450 Complex Subunit 14 F2 (CYP4F2) and CytochromeP450 Complex Subunit2C9 (CYP2C9), is a candidate predictor for appropriate maintenance warfarin dose.
Efficiency of exome sequencing for the molecular diagnosis of pseudoxanthoma elasticum.
New
Vanakker et al., Gent, Belgium. In J Invest Dermatol, Apr 2015
The molecular etiology of pseudoxanthoma elasticum (PXE), an autosomal recessive connective tissue disorder, has become increasingly complex as not only mutations in ATP-binding cassette family C member 6 (ABCC6) but also ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and gamma-glutamyl carboxylase (GGCX) can cause resembling phenotypes.
Bleeding and non-bleeding phenotypes in patients with GGCX gene mutations.
Oldenburg et al., Bonn, Germany. In Thromb Res, 2014
Functional limitations for the vitamin K cycle, caused either by mutations in gamma-glutamyl carboxylase or vitamin K epoxide reductase genes, result in hereditary deficiency of vitamin K-dependent coagulation factors (VKCFD1 and VKCFD2, respectively).
Genetic determinants of acenocoumarol and warfarin maintenance dose requirements in Slavic population: a potential role of CYP4F2 and GGCX polymorphisms.
Undas et al., Kraków, Poland. In Thromb Res, 2014
Cytochrome P450 4F2 isoform (CYP4F2), gamma-glutamyl carboxylase (GGCX) and apolipoprotein E (APOE) polymorphisms have been suggested to be of minor significance.
Optimal dosing of warfarin and other coumarin anticoagulants: the role of genetic polymorphisms.
Review
Daly, Newcastle upon Tyne, United Kingdom. In Arch Toxicol, 2013
Additional less common polymorphisms in these genes together with polymorphisms in other genes relevant to blood coagulation such as the cytochrome P450 CYP4F2, gamma-glutamyl carboxylase, calumenin and cytochrome P450 oxidoreductase may also be significant predictors of dose, especially in ethnic groups such as Africans where there have been fewer genetic studies compared with European populations.
A fluorescent method to determine vitamin K-dependent gamma-glutamyl carboxylase activity.
Krüger et al., Aachen, Germany. In Anal Biochem, 2012
The gamma (γ)-glutamyl carboxylase is a key enzyme in vitamin K-dependent carboxylation of proteins involved in hemostasis and inflammation.
[Factors influencing the variable response to treatment with oral anticoagulants].
Review
Mosiewicz et al., In Wiad Lek, 2011
Less important are mutations in genes encoding other subunits of cytochrome P450, vitamin K dependent clotting factors, calumenin, gamma-glutamyl carboxylase, apolipoprotein E and microsomal epoxide hydrolase.
Functional polymorphism in gamma-glutamylcarboxylase is a risk factor for severe neonatal hemorrhage.
De Paepe et al., Gent, Belgium. In J Pediatr, 2011
Molecular analysis of the gamma-glutamylcarboxylase gene revealed a heterozygous single nucleotide polymorphism, which decreases carboxylase activity and induces VK-dependent coagulation deficiency.
[Optimalisation of treatment with vitamin K antagonists--the role of gene polymorphisms].
Review
Undas et al., Kraków, Poland. In Kardiol Pol, 2009
Polymorphisms of cytochrome P450 4F2 isoform (CYP4F2), apolipoprotein E (APOE) and gamma-glutamyl carboxylase (GGCX) are of minor or negligible importance.
Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung.
GeneRIF
Rannels et al., United States. In Am J Physiol Lung Cell Mol Physiol, 2003
Both carboxylase activity and formation of gamma-carboxyglutamate (Gla)-containing proteins were stimulated by dexamethasone (Dex) in fetal type II lung cells
Cloning and expression of the cDNA for human gamma-glutamyl carboxylase.
Impact
Stafford et al., Chapel Hill, United States. In Science, 1992
The cDNA for human gamma-glutamyl carboxylase, which accomplishes the post-translational modification required for the activity of all of the vitamin K-dependent proteins, was cloned.
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