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Adaptor-related protein complex 1, gamma 1 subunit

gamma-adaptin, gamma1-adaptin
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AP-1, p16, V1a, CAN, GGA1
Papers on gamma-adaptin
Eight Novel Mutations Confirm the Role of AAGAB in Punctate Palmoplantar Keratoderma Type 1 (Buschke-Fischer-Brauer) and Show Broad Phenotypic Variability.
New
Eckstein et al., München, Germany. In Acta Derm Venereol, Dec 2015
We recently identified mutations in 3 families, in the AAGAB gene on 15q, which encodes the alpha- and gamma-adaptin-binding protein p34.
Nonsense mutations in AAGAB cause punctate palmoplantar keratoderma type Buschke-Fischer-Brauer.
Strom et al., München, Germany. In Am J Hum Genet, 2012
AAGAB encodes the alpha-and gamma-adaptin-binding protein p34 and might play a role in membrane traffic as a chaperone.
The sugar is sIRVed: sorting Glut4 and its fellow travelers.
Review
Pilch et al., Boston, United States. In Traffic, 2011
This facilitates clustering of the IRV proteins into an oligomeric complex, which can then be distributed from the donor membranes to the IRV as a single entity with the help of adaptors, such as Golgi-localized, gamma-adaptin ear-containing, ARF-binding (GGA).
A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR.
Haucke et al., Berlin, Germany. In J Biol Chem, 2010
Furthermore, we identify a novel subtype of AP-1-binding motif within Gadkin that specifically associates with the gamma1-adaptin ear domain.
EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.
Caplan et al., Omaha, United States. In J Cell Sci, 2009
Although Arf1 still assembled onto these dispersed Golgi membranes, the level of AP-1 gamma-adaptin recruited to the Golgi was diminished.
gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway.
Prange et al., Mainz, Germany. In J Biol Chem, 2008
These defects cannot be rescued by gamma1-adaptin, a closely related homolog of gamma2-adaptin, which is unable to bind ubiquitin.
SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking.
Carlsson et al., Umeå, Sweden. In J Cell Sci, 2008
However, contrary to SNX9, which primarily acts in clathrin-mediated endocytosis at the plasma membrane, endogenous SNX18 localized to AP-1- and PACS1-positive endosomal structures, which were devoid of clathrin and resistant to Brefeldin A. Moreover, a gamma-adaptin recognition motif was defined in a low-complexity region of SNX18, and a complex of endogenous SNX18 and AP-1 could be immunoprecipitated after Brefeldin A treatment.
Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells.
Schechter et al., Los Angeles, United States. In Exp Eye Res, 2007
In the present study, confocal immunofluorescence microscopy revealed that natively expressed PRL and over-expressed PRL co-localized with PRL receptors (PRLR); rab11, a marker for the recycling endosome; gamma-adaptin, a marker for the Golgi complex and trans-Golgi network; and rab7, a marker for the autophagic lysosomal apparatus.
Dileucine signal-dependent and AP-1-independent targeting of a lysosomal glycoprotein in Trypanosoma brucei.
Field et al., Cambridge, United Kingdom. In Mol Biochem Parasitol, 2007
However, this targeting does not require AP-1, as knockdown of the trypanosome gamma-adaptin subunit by RNAi has no detectable effect on the location or maturation of p67.
Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation.
GeneRIF
Prange et al., Mainz, Germany. In J Biol Chem, 2006
Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation
Ubiquitin-binding proteins: similar, but different.
Review
Hartmann-Petersen et al., Copenhagen, Denmark. In Essays Biochem, 2004
The smaller groups of UIM (ubiquitin-interacting motif), GAT [GGA (Golgi-associated gamma-adaptin homologous) and Tom1 (target of Myb 1)], CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation), UEV [ubiquitin E2 (ubiquitin-conjugating enzyme) variant] and NZF (nuclear protein localization gene 4 zinc finger) domain-containing proteins appear to have more specialized functions.
The structure and function of GGAs, the traffic controllers at the TGN sorting crossroads.
Review
Wakatsuki et al., Kyoto, Japan. In Cell Struct Funct, 2003
GGAs (Golgi-localizing, gamma-adaptin ear homology domain, ARF-binding proteins) are a family of monomeric clathrin adaptor proteins that are conserved from yeasts to humans.
Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif.
Impact
Payne et al., Los Angeles, United States. In Nat Cell Biol, 2003
Clathrin-coated vesicles (CCVs) are a central component of endocytosis and traffic between the trans-Golgi network (TGN) and endosomes.
Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin.
GeneRIF
Owen et al., Cambridge, United Kingdom. In Structure, 2002
1.8 A resolution structure and binding site for Eps15 and gamma-synergin is presented
Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.
GeneRIF
Wakatsuki et al., Tsukuba, Japan. In Nat Struct Biol, 2002
crystal structure of the human gamma 1-adaptin ear domain consists solely of an immunoglobulin-like fold, unlike the alpha-adaptin ear domain
Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain.
GeneRIF
Nakayama et al., Tsukuba, Japan. In J Biochem, 2002
Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain.The interaction may play a role in membrane trafficking between the trans-Golgi network and endosomes.
Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.
Impact
Wakatsuki et al., Tsukuba, Japan. In Nature, 2002
GGAs (Golgi-localizing, gamma-adaptin ear homology domain, ARF-interacting proteins) are critical for the transport of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ADP-ribosylation factor (ARF), and clathrin.
Dynamin, a GTPase involved in the initial stages of endocytosis.
Review
Shpetner et al., Shrewsbury, United States. In Ciba Found Symp, 1992
Overexpression of mutant forms of dynamin in vivo using Cos-7 cells inhibits transferrin uptake and alters the distribution of clathrin and of alpha-adaptin, but not gamma-adaptin.
Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: effects of brefeldin A and G protein activators.
Impact
Kreis et al., Cambridge, United Kingdom. In Cell, 1992
Brefeldin A (BFA) causes a rapid redistribution of coat proteins (e.g., gamma-adaptin) associated with the clathrin-coated vesicles that bud from the trans-Golgi network (TGN), while the clathrin-coated vesicles that bud from the plasma membrane are unaffected.
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