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UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

GalT, N-Acetyllactosamine Synthase, beta 1,4-galactosyltransferase
The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Alpha-1, CD45
Papers using GalT antibodies
The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei
Supplier
Lippincott-Schwartz Jennifer et al., In The Journal of Cell Biology, 1997
... pUASp:Lys-GFP-KDEL and pUASp:GalT-GFP transgenic lines have been previously ...
Papers on GalT
Postnatal xenogeneic B-cell tolerance in swine following in utero intraportal antigen exposure.
New
Vagefi et al., Boston, United States. In Xenotransplantation, 28 Sep 2015
METHODS: Nine fetuses from an alpha-1,3-galactosyltransferase gene knockout (GalT-KO) MGH-miniature swine sow underwent transuterine ultrasound-guided intraportal injection of T-cell depleted baboon bone marrow (B-BM) at mid-gestation.
The Role of Liver Sinusoidal Endothelial Cells in Induction of Carbohydrate Reactive B Cells Tolerance Through the Programmed Death 1/Programmed Death Ligand 1 Pathway.
New
Ohdan et al., Hiroshima, Japan. In Transplantation, 05 Sep 2015
METHODS: Using adoptive transfer of LSECs from wild type (WT) C57BL/6J mice to congenic α1,3-galactosyltransferase gene knockout (GalT) mice, we established orthotropic GalT → GalT LSEC chimera mice.
Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs.
New
Nagashima et al., Ōsaka, Japan. In J Reprod Dev, 26 Aug 2015
Porcine fibroblast cell lines were derived from homozygous α1,3-galactosyltransferase (GalT) KO pigs.
Two-level inhibition of galK expression by Spot 42: Degradation of mRNA mK2 and enhanced transcription termination before the galK gene.
New
Lim et al., Taejŏn, South Korea. In Proc Natl Acad Sci U S A, Jul 2015
The Escherichia coli gal operon has the structure Pgal-galE-galT-galK-galM.
HCG induces β1,4-GalT I expression and promotes embryo implantation.
New
Kong et al., Dalian, China. In Int J Clin Exp Pathol, Dec 2014
Beta1, 4-Galactosyltransferase-I (β1,4-GalT-I) is ubiquitously expresses in human tissues with the exception of the brain.
The sweets standing at the borderline between allo- and xenotransplantation.
Review
Kim et al., Seoul, South Korea. In Xenotransplantation, 2013
Although researchers have been able to develop α1,3-galactosyltransferase (GalT) gene knockout (KO) pigs, there remain unclarified non-Gal antigens that prevent xenotransplantation.
Two Tunisian patients with Peters plus syndrome harbouring a novel splice site mutation in the B3GALTL gene that modulates the mRNA secondary structure.
GeneRIF
Fakhfakh et al., Sfax, Tunisia. In Gene, 2012
A novel homozygous c.597-2A>G mutation was identified in both patients with Peters plus syndrome harbouring a novel splice site mutation in the B3GALTL gene
Altered oligosaccharide structures reduce colitis induction in mice defective in β-1,4-galactosyltransferase.
GeneRIF
Miyoshi et al., Ōsaka, Japan. In Gastroenterology, 2012
revealed increased expression of polylactosamines on B4galt1(+/-) B cells and macrophages, compared with B4galt1(+/+) cells
Carbohydrate antigens.
Review
Fukuzawa et al., Ōsaka, Japan. In Curr Opin Organ Transplant, 2012
RECENT FINDINGS: Studies related to iGb3 and neoantigens after knocking out GalT (GGTA1) were reviewed.
[Regulation of human β-1,4-galactosyltransferase V gene expression in cancer cells].
Review
Furukawa et al., Nagaoka, Japan. In Yakugaku Zasshi, 2011
β-1,4-Galactosyltransferase (β-1,4-GalT) V - whose human and mouse genes were cloned by us - has been suggested to be involved in the biosyntheses of N-glycans, O-glycans, and lactosylceramide by in vitro studies.
Vertebral defects in patients with Peters plus syndrome and mutations in B3GALTL.
GeneRIF
Gasparini et al., In Ophthalmic Genet, 2011
Vertebral defects in a patient with Peters plus syndrome and mutations in B3GALTL.
Gal/non-Gal antigens in pig tissues and human non-Gal antibodies in the GalT-KO era.
Review
Breimer, Göteborg, Sweden. In Xenotransplantation, 2011
Our knowledge regarding Gal and non-Gal antigens in GalT-KO pig tissues can be summarized as α3Galactosyl-tranferase gene knock out eliminates the Galα3Galβ4GlcNAc-R antigen expression in pig tissues as well as anti-Gal antibody binding.
Which anti-platelet therapies might be beneficial in xenotransplantation?
Review
Robson et al., Boston, United States. In Xenotransplantation, 2011
The development of α-1,3-galactosyltransferase gene-knockout (GalT-KO) swine with the removal of a dominant xeno-antigen has been an important advance; however, delayed xenograft and acute vascular reaction in GalT-KO animals persist.
A novel nonsense B3GALTL mutation confirms Peters plus syndrome in a patient with multiple malformations and Peters anomaly.
GeneRIF
Dollfus et al., Strasbourg, France. In Ophthalmic Genet, 2010
The present report confirms the wide clinical spectrum of Peters plus syndrome, underlines the major clinical criteria of the syndrome and the major implication of B3GALTL gene in this condition.
Novel B3GALTL mutation in Peters-plus Syndrome.
GeneRIF
Chassaing et al., In Clin Genet, 2009
Novel B3GALTL mutation in Peters-plus Syndrome
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.
Impact
Cooper et al., Boston, United States. In Nat Med, 2005
Hearts from alpha1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen.
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
Impact
Sachs et al., Boston, United States. In Nat Med, 2005
Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach.
Large-scale production of UDP-galactose and globotriose by coupling metabolically engineered bacteria.
Impact
Ozaki et al., Machida, Japan. In Nat Biotechnol, 1998
Recombinant E. coli that overexpress the UDP-Gal biosynthetic genes galT, galK, and galU were generated.
Translational coupling at an intercistronic boundary of the Escherichia coli galactose operon.
Impact
Rosenberg et al., In Cell, 1982
These results demonstrate that the galK gene is translationally coupled to the gene immediately preceding galK in the gal operon (that is, galT), and that the coupling effect depends primarily on the position at which upstream translation terminates relative to the galK start site.
IS1 insertion generates duplication of a nine base pair sequence at its target site.
Impact
Grindley, In Cell, 1978
DNA sequences of portions of the wild-type galT gene which act as the target sites for these insertions, as well as the corresponding gal/IS1 junctions, are reported.
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