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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Mar 2014.

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

GalT, N-Acetyllactosamine Synthase, beta 1,4-galactosyltransferase
The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Alpha-1, CD45
Papers using GalT antibodies
The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei
Supplier
Lippincott-Schwartz Jennifer et al., In The Journal of Cell Biology, 1997
... pUASp:Lys-GFP-KDEL and pUASp:GalT-GFP transgenic lines have been previously ...
Papers on GalT
Subfertility and growth restriction in a new galactose-1 phosphate uridylyltransferase (GALT) - deficient mouse model.
New
Lai et al., Salt Lake City, United States. In Eur J Hum Genet, 19 Mar 2014
UNLABELLED: The first GalT gene knockout (KO) mouse model for Classic Galactosemia (OMIM 230400) accumulated some galactose and its metabolites upon galactose challenge, but was seemingly fertile and symptom free.
Cell-based galactosemia diagnosis system based on a galactose assay using a bioluminescent Escherichia coli array.
New
Park et al., Taejŏn, South Korea. In Anal Chem, Dec 2013
For this purpose, a galT knockout strain [galT(-) cell] of E. coli was genetically constructed so that cell growth is not promoted by galactose but rather by glucose present in a sample.
The alpha1,3GalT knockout/alpha1,2FucT transgenic pig does not appear to have an advantage over the alpha1,3GalT knockout pig with respect to glycolipid reactivity with human serum antibodies.
New
Breimer et al., Göteborg, Sweden. In Xenotransplantation, Dec 2013
This work is the first descriptive analysis of glycolipids from the GalT-KO/FucT-TG pig.
Increased levels of anti-non-Gal IgG following pig-to-baboon bone marrow transplantation correlate with failure of engraftment.
New
Sachs et al., Boston, United States. In Xenotransplantation, Nov 2013
BACKGROUND: The development of genetically modified pigs, which lack the expression of alpha 1-3 galactosyl transferase, (GalT-KO pigs) has facilitated the xenogeneic transplantation of porcine organs and tissues into primates by avoiding hyperacute rejection due to pre-existing antibodies against the Gal epitope.
Inactivation of metabolic genes causes short- and long-range dys-regulation in Escherichia coli metabolic network.
Adhya et al., Davis, United States. In Plos One, 2012
Analysis of metabolomics data in wild-type and D-galactose non-utilizing mutants, galT, galU and galE, reveal the large metabolic differences between the wild-type and the mutants when the strains were grown in D-galactose.
Two Tunisian patients with Peters plus syndrome harbouring a novel splice site mutation in the B3GALTL gene that modulates the mRNA secondary structure.
GeneRIF
Fakhfakh et al., Sfax, Tunisia. In Gene, 2012
A novel homozygous c.597-2A>G mutation was identified in both patients with Peters plus syndrome harbouring a novel splice site mutation in the B3GALTL gene
Altered oligosaccharide structures reduce colitis induction in mice defective in β-1,4-galactosyltransferase.
GeneRIF
Miyoshi et al., Ōsaka, Japan. In Gastroenterology, 2012
revealed increased expression of polylactosamines on B4galt1(+/-) B cells and macrophages, compared with B4galt1(+/+) cells
Carbohydrate antigens.
Review
Fukuzawa et al., Ōsaka, Japan. In Curr Opin Organ Transplant, 2012
RECENT FINDINGS: Studies related to iGb3 and neoantigens after knocking out GalT (GGTA1) were reviewed.
[Regulation of human β-1,4-galactosyltransferase V gene expression in cancer cells].
Review
Furukawa et al., Nagaoka, Japan. In Yakugaku Zasshi, 2011
β-1,4-Galactosyltransferase (β-1,4-GalT) V - whose human and mouse genes were cloned by us - has been suggested to be involved in the biosyntheses of N-glycans, O-glycans, and lactosylceramide by in vitro studies.
Vertebral defects in patients with Peters plus syndrome and mutations in B3GALTL.
GeneRIF
Gasparini et al., In Ophthalmic Genet, 2011
Vertebral defects in a patient with Peters plus syndrome and mutations in B3GALTL.
Gal/non-Gal antigens in pig tissues and human non-Gal antibodies in the GalT-KO era.
Review
Breimer, Göteborg, Sweden. In Xenotransplantation, 2011
Our knowledge regarding Gal and non-Gal antigens in GalT-KO pig tissues can be summarized as α3Galactosyl-tranferase gene knock out eliminates the Galα3Galβ4GlcNAc-R antigen expression in pig tissues as well as anti-Gal antibody binding.
Controlling coagulation dysregulation in xenotransplantation.
Review
d'Apice et al., Melbourne, Australia. In Curr Opin Organ Transplant, 2011
PURPOSE OF REVIEW: Deletion of the α1,3-galactosyltransferase (GalT) gene in pigs has removed a major xenoantigen but has not eliminated the problem of dysregulated coagulation and vascular injury.
Which anti-platelet therapies might be beneficial in xenotransplantation?
Review
Robson et al., Boston, United States. In Xenotransplantation, 2011
The development of α-1,3-galactosyltransferase gene-knockout (GalT-KO) swine with the removal of a dominant xeno-antigen has been an important advance; however, delayed xenograft and acute vascular reaction in GalT-KO animals persist.
A novel nonsense B3GALTL mutation confirms Peters plus syndrome in a patient with multiple malformations and Peters anomaly.
GeneRIF
Dollfus et al., Strasbourg, France. In Ophthalmic Genet, 2010
The present report confirms the wide clinical spectrum of Peters plus syndrome, underlines the major clinical criteria of the syndrome and the major implication of B3GALTL gene in this condition.
Novel B3GALTL mutation in Peters-plus Syndrome.
GeneRIF
Chassaing et al., In Clin Genet, 2009
Novel B3GALTL mutation in Peters-plus Syndrome
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.
Impact
Cooper et al., Boston, United States. In Nat Med, 2005
Hearts from alpha1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen.
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
Impact
Sachs et al., Boston, United States. In Nat Med, 2005
Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach.
Large-scale production of UDP-galactose and globotriose by coupling metabolically engineered bacteria.
Impact
Ozaki et al., Machida, Japan. In Nat Biotechnol, 1998
Recombinant E. coli that overexpress the UDP-Gal biosynthetic genes galT, galK, and galU were generated.
Translational coupling at an intercistronic boundary of the Escherichia coli galactose operon.
Impact
Rosenberg et al., In Cell, 1982
These results demonstrate that the galK gene is translationally coupled to the gene immediately preceding galK in the gal operon (that is, galT), and that the coupling effect depends primarily on the position at which upstream translation terminates relative to the galK start site.
IS1 insertion generates duplication of a nine base pair sequence at its target site.
Impact
Grindley, In Cell, 1978
DNA sequences of portions of the wild-type galT gene which act as the target sites for these insertions, as well as the corresponding gal/IS1 junctions, are reported.
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