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UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

GalT, N-Acetyllactosamine Synthase, beta 1,4-galactosyltransferase
The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS).[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Alpha-1, CD45
Papers using GalT antibodies
The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei
Supplier
Lippincott-Schwartz Jennifer et al., In The Journal of Cell Biology, 1997
... pUASp:Lys-GFP-KDEL and pUASp:GalT-GFP transgenic lines have been previously ...
Papers on GalT
Roles of Escherichia coli ZinT in cobalt, mercury and cadmium resistance and structural insights into the metal binding mechanism.
New
Vicente et al., Lisbon, Portugal. In Metallomics, 13 Feb 2016
From the positive hits, six metal ions were evaluated in terms of their toxicity towards an E. coli strain depleted of ZinT (ΔzinT) using as control a strain deleted in the galT gene (ΔgalT).
Galactose-1 phosphate uridylyltransferase (GalT) gene: A novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts.
New
Lai et al., United States. In Biochem Biophys Res Commun, 08 Feb 2016
In this study, we compared the growth and the expression levels of the key components of the PI3K/Akt growth signaling pathway in primary fibroblasts derived from normal and galactose-1 phosphate uridylyltransferase (GalT)-deficient mice, the latter exhibited a subfertility phenotype in adult females and growth restriction in both sexes.
Regulation of EPS production in Lactobacillus casei LC2W through metabolic engineering.
New
Guo et al., Shanghai, China. In Lett Appl Microbiol, 31 Dec 2015
The results suggested that nox, pfk, rfbB and galT genes were the largest contributors to EPS biosynthesis in this study, which elevated EPS yield by 46·0, 20, 17·4 and 19·6% respectively.
Rat-to-Chinese tree shrew heart transplantation is a novel small animal model to study non-Gal-mediated discordant xenograft humoral rejection.
New
Qi et al., Xiamen, China. In Xenotransplantation, Nov 2015
UNLABELLED: Since α-1,3-galactosyltransferase knockout (GalT-KO) pigs became available, there has been an increasing interest in non-Gal natural antibody (nAb)-mediated xenograft rejection.
The Role of Liver Sinusoidal Endothelial Cells in Induction of Carbohydrate Reactive B Cells Tolerance Through the Programmed Death 1/Programmed Death Ligand 1 Pathway.
New
Ohdan et al., Hiroshima, Japan. In Transplantation, Nov 2015
METHODS: Using adoptive transfer of LSECs from wild type (WT) C57BL/6J mice to congenic α1,3-galactosyltransferase gene knockout (GalT) mice, we established orthotropic GalT → GalT LSEC chimera mice.
Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs.
New
Nagashima et al., Ōsaka, Japan. In J Reprod Dev, Nov 2015
Porcine fibroblast cell lines were derived from homozygous α1,3-galactosyltransferase (GalT) KO pigs.
Postnatal xenogeneic B-cell tolerance in swine following in utero intraportal antigen exposure.
New
Vagefi et al., Boston, United States. In Xenotransplantation, Sep 2015
METHODS: Nine fetuses from an alpha-1,3-galactosyltransferase gene knockout (GalT-KO) MGH-miniature swine sow underwent transuterine ultrasound-guided intraportal injection of T-cell depleted baboon bone marrow (B-BM) at mid-gestation.
Two-level inhibition of galK expression by Spot 42: Degradation of mRNA mK2 and enhanced transcription termination before the galK gene.
New
Lim et al., Taejŏn, South Korea. In Proc Natl Acad Sci U S A, Jul 2015
The Escherichia coli gal operon has the structure Pgal-galE-galT-galK-galM.
HCG induces β1,4-GalT I expression and promotes embryo implantation.
Kong et al., Dalian, China. In Int J Clin Exp Pathol, 2014
Beta1, 4-Galactosyltransferase-I (β1,4-GalT-I) is ubiquitously expresses in human tissues with the exception of the brain.
Imaging the Intracellular Trafficking of APP with Photoactivatable GFP.
Pasternak et al., Kenya. In J Vis Exp, 2014
By using the Golgi marker Galactosyl transferase coupled to Cyan Fluorescent Protein (GalT-CFP) as a target, we are able to accurately photoactivate APP in the trans-Golgi network.
Two Tunisian patients with Peters plus syndrome harbouring a novel splice site mutation in the B3GALTL gene that modulates the mRNA secondary structure.
GeneRIF
Fakhfakh et al., Sfax, Tunisia. In Gene, 2012
A novel homozygous c.597-2A>G mutation was identified in both patients with Peters plus syndrome harbouring a novel splice site mutation in the B3GALTL gene
Altered oligosaccharide structures reduce colitis induction in mice defective in β-1,4-galactosyltransferase.
GeneRIF
Miyoshi et al., Ōsaka, Japan. In Gastroenterology, 2012
revealed increased expression of polylactosamines on B4galt1(+/-) B cells and macrophages, compared with B4galt1(+/+) cells
Vertebral defects in patients with Peters plus syndrome and mutations in B3GALTL.
GeneRIF
Gasparini et al., In Ophthalmic Genet, 2011
Vertebral defects in a patient with Peters plus syndrome and mutations in B3GALTL.
A novel nonsense B3GALTL mutation confirms Peters plus syndrome in a patient with multiple malformations and Peters anomaly.
GeneRIF
Dollfus et al., Strasbourg, France. In Ophthalmic Genet, 2010
The present report confirms the wide clinical spectrum of Peters plus syndrome, underlines the major clinical criteria of the syndrome and the major implication of B3GALTL gene in this condition.
Novel B3GALTL mutation in Peters-plus Syndrome.
GeneRIF
Chassaing et al., In Clin Genet, 2009
Novel B3GALTL mutation in Peters-plus Syndrome
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
Impact
Sachs et al., Boston, United States. In Nat Med, 2005
Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach.
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.
Impact
Cooper et al., Boston, United States. In Nat Med, 2005
Hearts from alpha1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen.
Large-scale production of UDP-galactose and globotriose by coupling metabolically engineered bacteria.
Impact
Ozaki et al., Machida, Japan. In Nat Biotechnol, 1998
Recombinant E. coli that overexpress the UDP-Gal biosynthetic genes galT, galK, and galU were generated.
Translational coupling at an intercistronic boundary of the Escherichia coli galactose operon.
Impact
Rosenberg et al., In Cell, 1982
These results demonstrate that the galK gene is translationally coupled to the gene immediately preceding galK in the gal operon (that is, galT), and that the coupling effect depends primarily on the position at which upstream translation terminates relative to the galK start site.
IS1 insertion generates duplication of a nine base pair sequence at its target site.
Impact
Grindley, In Cell, 1978
DNA sequences of portions of the wild-type galT gene which act as the target sites for these insertions, as well as the corresponding gal/IS1 junctions, are reported.
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