gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Galanin receptor 3

GalR3, galanin receptor 3
binds galanin; mediates activation of GIRK1 and GIRK4 channel inward K+ currents; may play a role in neurotransmitter release [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: GalR2, galanin receptor, Neuropeptide, V1a, CAN
Papers on GalR3
In vitro toxicity of the galanin receptor 3 antagonist SNAP 37889.
New
Kofler et al., Salzburg, Austria. In Neuropeptides, Jan 2016
UNASSIGNED: Galanin and its receptors (GAL1, GAL2, GAL3) modulate a range of neuronal, immune and vascular activities.
Galanin receptors as a potential target for neurological disease.
New
Langel et al., Tartu, Estonia. In Expert Opin Ther Targets, Dec 2015
Galanin exerts its biological activities through three different G protein-coupled receptors, GalR1, GalR2 and GalR3.
Distribution of galanin receptors in the human eye.
New
Reitsamer et al., Salzburg, Austria. In Exp Eye Res, Sep 2015
Meeting the Helsinki-Declaration, human eyes (n = 6; 45-83 years of age, of both sex, post mortem time 10-19 h) were obtained from the cornea bank and prepared for immunohistochemistry against GAL receptors 1-3 (GALR1-GALR3).
Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease.
New
Hökfelt et al., Stockholm, Sweden. In Acta Neuropathol, Apr 2015
The loss of SSTR2 transcripts in the LC neurons appeared selective, since tyrosine hydroxylase, dopamine β-hydroxylase, galanin or galanin receptor 3 mRNAs remained unchanged.
Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice.
Bian et al., Hong Kong, Hong Kong. In Sci Rep, 2014
Galanin receptor 2 (GALR2) antagonist M871, but not Galanin receptor 3 (GALR3) antagonist SNAP37899, effectively suppressed the stimulatory effects of spexin on intestinal/colonic smooth muscle contraction, which could be eliminated by extracellular [Ca(2+)] removal and L-type voltage-dependent Ca(2+) channel (VDCC) inhibitor nifedipine.
Brain galanin system genes interact with life stresses in depression-related phenotypes.
Bagdy et al., Budapest, Hungary. In Proc Natl Acad Sci U S A, 2014
Here we report that variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events in a European white population cohort totaling 2,361 from Manchester, United Kingdom and Budapest, Hungary.
Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells.
Xu et al., Beijing, China. In Biochem Biophys Res Commun, 2014
This activation was mediated by GalR2, since its agonist AR-M1896 mimicked the effect of galanin, and since galanin did not facilitate BK currents in cells co-expressing cDNAs of BK and GalR1 or GalR3.
Differential effects of prenatal stress in female 5-HTT-deficient mice: towards molecular mechanisms of resilience.
van den Hove et al., Maastricht, Netherlands. In Dev Neurosci, 2013
Results indicate that, amongst others, Fos-induced growth factor (Figf), galanin receptor 3 (Galr3), growth hormone (Gh) and prolactin (Prl) were differentially expressed specifically in resilient offspring when compared to controls, and that the hippocampal expression of these genes showed several strong correlations with various measures of the hypothalamus-pituitary-adrenal axis (re)activity.
Galanin-3 receptor antagonism by SNAP 37889 reduces motivation to self-administer alcohol and attenuates cue-induced reinstatement of alcohol-seeking in iP rats.
Djouma et al., Australia. In J Pharmacol Sci, 2013
The galanin-3 receptor (GALR3) subtype is implicated in modulating the consumption of alcohol and has therefore been identified as a potential target for new pharmacotherapies to treat alcohol use disorders.
Galanin receptor 3--a potential target for acute pancreatitis therapy.
GeneRIF
Saccone et al., Adelaide, Australia. In Neurogastroenterol Motil, 2011
Data show that galanin receptor mRNA and protein are expressed in mouse pancreas, with GALR3 mRNA predominating.
Effects of intracerebroventricular galanin or a galanin receptor 2/3 agonist on the lesion induced by transient occlusion of the middle cerebral artery in female rats.
GeneRIF
Theodorsson et al., Linköping, Sweden. In Neuropeptides, 2011
Data show that a galanin or a galanin receptor R2/3 agonist doubles the size of the ischemic lesion following middle cerebral artery occlusion in rats.
Determining receptor-ligand interaction of human galanin receptor type 3.
GeneRIF
Langel et al., Stockholm, Sweden. In Neurochem Int, 2010
Mutated human GalR3 receptors are tested with competitive binding analysis in vitro, identifying six different sites in GalR3 that determine binding to galanin.
Galanin, galanin receptors, and drug targets.
Review
Bartfai et al., Los Angeles, United States. In Exs, 2009
Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous physiological and pathological processes through interactions with three G-protein-coupled receptors, GalR1 through GalR3.
Galanin, galanin receptor subtypes and depression-like behaviour.
Review
Ogren et al., Stockholm, Sweden. In Exs, 2009
Thus, stimulation of GalR1 and/or GalR3 receptors results in depression-like phenotype, while activation of the GalR2 receptor reduces depression-like behaviour in the rat.
Effects of norepinephrine on galanin expression in dorsal root ganglion neurons in vitro.
Li et al., Jinan, China. In Curr Ther Res Clin Exp, 2009
It has been suggested that galanin receptor (GalR) 1 and GalR3 activation induces analgesia at the level of the spinal cord, while activation of GalR2 has a pronociceptive role in the periphery.
Evidence that the modulatory effect of galanin on inflammatory edema formation is mediated by the galanin receptor 3 in the murine microvasculature.
GeneRIF
Brain et al., Salzburg, Austria. In J Mol Neurosci, 2009
GalR3 is the receptor subtype mediating galanin's effects on the dermal microvasculature
Galanin, galanin receptors and drug targets.
Review
Bartfai et al., Los Angeles, United States. In Cell Mol Life Sci, 2008
Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous physiological and pathological processes through interactions with three G-protein-coupled receptors, GalR1 through GalR3.
Galanin, galanin receptor subtypes and depression-like behaviour.
Review
Ogren et al., Stockholm, Sweden. In Cell Mol Life Sci, 2008
Thus, stimulation of GalR1 and/or GalR3 receptors results in depression-like phenotype, while activation of the GalR2 receptor attenuates depression-like behaviour.
The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease.
Review
Kofler et al., Salzburg, Austria. In Pharmacol Ther, 2007
The galanin receptor family currently comprises 3 members, GalR1, GalR2, and GalR3, which are all G-protein-coupled receptors.
Alcoholism is associated with GALR3 but not two other galanin receptor genes.
GeneRIF
Enoch et al., Bethesda, United States. In Genes Brain Behav, 2007
GALR3 showed a significant association with alcoholism that was driven by one SNP (rs3,091,367).
share on facebooktweetadd +1mail to friends