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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Galanin receptor 2

GalR2, galanin receptor 2
mediates inositol phospholipid turnover and intracellular calcium levels; functions through the activation of phospholipase C [RGD, Feb 2006] (from NCBI)
Papers on GalR2
Expression of galanin and galanin receptor mRNA in skin during the formation of granulation tissue.
Hoshino et al., Shizuoka, Japan. In Endocrine, 2011
This study found that GALR2 mRNA was expressed in granulation tissue, including in pericytes, but only in pericytes that had been dissociated from endothelial cells.
Galanin receptor 2 overexpressing mice display an antidepressive-like phenotype: possible involvement of the subiculum.
Xu et al., Stockholm, Sweden. In Neuroscience, 2011
Three age groups of the Galr2 overexpressing mice demonstrated decreased levels of immobility in the forced swim test, indicative of antidepressive-like behavior and/or increased stress resistance.
Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma.
D'Silva et al., Ann Arbor, United States. In Cell Signal, 2011
galanin receptor 2 promotes cell proliferation and survival, and promotes tumor growth, consistent with an oncogenic role for GALR2 in squamous cell carcinoma of the head and neck
Effects of intracerebroventricular galanin or a galanin receptor 2/3 agonist on the lesion induced by transient occlusion of the middle cerebral artery in female rats.
Theodorsson et al., Linköping, Sweden. In Neuropeptides, 2011
Data show that a galanin or a galanin receptor R2/3 agonist doubles the size of the ischemic lesion following middle cerebral artery occlusion in rats.
Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia.
Donaldson et al., Bristol, United Kingdom. In Mol Pain, 2010
High level of endogenous galanin in injured primary afferents activates peripheral GalR2, which leads to an increase in C-fibre mechanical activation thresholds and a marked reduction in evoked and ongoing nociceptive responses.
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