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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Galanin receptor 2

GalR2, galanin receptor 2
mediates inositol phospholipid turnover and intracellular calcium levels; functions through the activation of phospholipase C [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: galanin receptor, Neuropeptide, GalR3, V1a, ACID
Papers on GalR2
Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects.
Díaz-Cabiale et al., Málaga, Spain. In Brain Struct Funct, Jan 2016
The present study examined the interaction between Galanin receptor 2 (GALR2) and Neuropeptide Y Y1 receptor (NPYY1R) in the dentate gyrus (DG) of the Hippocampus in relation to depression-like behavior.
Galanin receptors as a potential target for neurological disease.
Langel et al., Tartu, Estonia. In Expert Opin Ther Targets, Dec 2015
Galanin exerts its biological activities through three different G protein-coupled receptors, GalR1, GalR2 and GalR3.
Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.
Holmes et al., Atlanta, United States. In Brain Res, Dec 2015
We propose a model in which LC-derived galanin has two distinct functions: as a neuromodulator, primarily acting via the galanin 1 receptor (GAL1), and as a trophic factor, primarily acting via galanin receptor 2 (GAL2).
Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.
Mineta et al., Hamamatsu, Japan. In Clin Exp Metastasis, Dec 2015
The methylation status of three genes-GAL, GALR1, and GALR2 was examined in HNSCC patient tumors using quantitative methylation-specific PCR (Q-MSP).
Involvement of galanin receptor 2 and CaMKII in galanin-induced antinociception in periaqueductal grey of rats.
Yu et al., Yantai, China. In Neurosci Lett, Oct 2015
The present study was performed to explore the effect of the galanin receptor 2 (GalR2) antagonist M871 on the galanin-induced antinociception in periaqueductal grey (PAG), and an involvement of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in the galanin-induced antinociception.
Elevated galanin may predict the risk of type 2 diabetes mellitus for development of Alzheimer's disease.
Bo et al., Yangzhou, China. In Mech Ageing Dev, Sep 2015
The current data support that activating central GalR2 attenuates insulin resistance and Alzheimer's disease feature in animal models.
Distribution of galanin receptors in the human eye.
Reitsamer et al., Salzburg, Austria. In Exp Eye Res, Sep 2015
GALR2 and GALR3 were present in few neurons of the INL, while GALR2 was also found surrounding retinal vessels.
G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer?
Carey et al., Japan. In Toxins (basel), Aug 2015
In this review, we discuss the roles that galanin receptor type 1 (GALR1) and type 2 (GALR2), tachykinin receptor type 1 (TACR1), and somatostatin receptor type 1 (SST1) play in HNSCC.
Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain.
Xu et al., Kunming, China. In Neurosci Res, Aug 2015
Western blot also showed, that the expression of galanin receptor 1 (GalR1) and galanin receptor 2 (GalR2) were significantly upregulated in NAc at 3 hour after a subcutaneous injection of carrageenin.
Galanin pathogenic mutations in temporal lobe epilepsy.
Antonarakis et al., Oran, Algeria. In Hum Mol Genet, Jul 2015
Functional analysis revealed that the p.A39E mutant showed antagonistic activity against galanin receptor 1 (GalR1)-mediated response, and decreased binding affinity and reduced agonist properties for GalR2.
Aberrant methylation inactivates somatostatin and somatostatin receptor type 1 in head and neck squamous cell carcinoma.
Mineta et al., Hamamatsu, Japan. In Plos One, 2014
SST methylation in 81% of HNSCC tumor specimens significantly correlated with tumor size (P = 0.043), stage (P = 0.008), galanin receptor type 2 (GALR2) methylation (P = 0.041), and tachykinin-1 (TAC1) (P = 0.040).
Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice.
Bian et al., Hong Kong, Hong Kong. In Sci Rep, 2014
Galanin receptor 2 (GALR2) antagonist M871, but not Galanin receptor 3 (GALR3) antagonist SNAP37899, effectively suppressed the stimulatory effects of spexin on intestinal/colonic smooth muscle contraction, which could be eliminated by extracellular [Ca(2+)] removal and L-type voltage-dependent Ca(2+) channel (VDCC) inhibitor nifedipine.
Galanin modulates the neural niche to favour perineural invasion in head and neck cancer.
D'Silva et al., Ann Arbor, United States. In Nat Commun, 2014
We show that the neuropeptide galanin (GAL) initiates nerve-tumour crosstalk via activation of its G protein-coupled receptor, GALR2.
The potential antidepressant and antidiabetic effects of galanin system.
Zhang et al., Yangzhou, China. In Pharmacol Biochem Behav, 2014
The current data support that activating central GalR2 attenuates insulin resistance and depressive feature in animal models.
Galanin receptor/neuropeptide y receptor interactions in the central nervous system.
Narváez et al., Málaga, Spain. In Curr Protein Pept Sci, 2013
The galanin fragment (Gal 1-15) preferring receptors may instead be formed by the GalR1-GalR2 heteromer which in the NTS may interact with Neuropeptide Y Y2 receptors.
Expression of galanin and galanin receptor mRNA in skin during the formation of granulation tissue.
Hoshino et al., Shizuoka, Japan. In Endocrine, 2011
This study found that GALR2 mRNA was expressed in granulation tissue, including in pericytes, but only in pericytes that had been dissociated from endothelial cells.
Galanin receptor 2 overexpressing mice display an antidepressive-like phenotype: possible involvement of the subiculum.
Xu et al., Stockholm, Sweden. In Neuroscience, 2011
Three age groups of the Galr2 overexpressing mice demonstrated decreased levels of immobility in the forced swim test, indicative of antidepressive-like behavior and/or increased stress resistance.
Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma.
D'Silva et al., Ann Arbor, United States. In Cell Signal, 2011
galanin receptor 2 promotes cell proliferation and survival, and promotes tumor growth, consistent with an oncogenic role for GALR2 in squamous cell carcinoma of the head and neck
Effects of intracerebroventricular galanin or a galanin receptor 2/3 agonist on the lesion induced by transient occlusion of the middle cerebral artery in female rats.
Theodorsson et al., Linköping, Sweden. In Neuropeptides, 2011
Data show that a galanin or a galanin receptor R2/3 agonist doubles the size of the ischemic lesion following middle cerebral artery occlusion in rats.
Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia.
Donaldson et al., Bristol, United Kingdom. In Mol Pain, 2010
High level of endogenous galanin in injured primary afferents activates peripheral GalR2, which leads to an increase in C-fibre mechanical activation thresholds and a marked reduction in evoked and ongoing nociceptive responses.
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