Galanin pathogenic mutations in temporal lobe epilepsy.
Oran, Algeria. In Hum Mol Genet, Jul 2015
Functional analysis revealed that the p.A39E mutant showed antagonistic activity against galanin receptor 1 (GalR1)-mediated response, and decreased binding affinity and reduced agonist properties for GalR2.
A role of supraspinal galanin in behavioural hyperalgesia in the rat.
Braga, Portugal. In Plos One, 2013
METHODS: In Wistar-Han males with a four week kaolin/carrageenan-induced monoarthritis (ARTH), paw-withdrawal latency (PWL) was assessed before and after DMH administration of exogenous GAL, a non-specific GALR antagonist (M40), a specific GALR1 agonist (M617) and a specific GALR2 antagonist (M871).