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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

GNAS complex locus

Galphas, C-G alpha s
Top mentioned proteins: CAN, V1a, Gi, HAD, ACID
Papers on Galphas
Effect of fluoxetine and adenosine receptor NECA agonist on G alpha q/11 protein of C6 glioma cells.
Lisá et al., Praha, Czech Republic. In Neuro Endocrinol Lett, 2011
We found significant changes as following: decreased G alpha Gq/11 for fluoxetine, low G alpha s for sertraline and both high G alpha q/11 and high G alpha s for citalopram.
Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.
Skiniotis et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2011
The active-state complex between an agonist-bound receptor and a guanine nucleotide-free G protein represents the fundamental signaling assembly for the majority of hormone and neurotransmitter signaling.
Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.
Kass et al., Baltimore, United States. In Sci Transl Med, 2011
Cardiac resynchronization therapy (CRT), in which both ventricles are paced to recoordinate contraction in hearts that are dyssynchronous from conduction delay, is the only heart failure (HF) therapy to date to clinically improve acute and chronic function while also lowering mortality.
UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway.
Steven et al., Toledo, United States. In Genetics, 2011
Rho-family GTPases play regulatory roles in many fundamental cellular processes.
Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes.
Fiserová et al., Praha, Czech Republic. In Neuro Endocrinol Lett, 2010
In contrast, no significant influence of G alpha s or G alpha i1,2 subunit levels of C6 glioma cells were observed.
[Juvenile granulosa-cell tumor: clinical and molecular expression].
Sultan et al., Montpellier, France. In Gynecol Obstet Fertil, 2009
According to our data, FSH signaling-transduction pathway, such as a constitutionally activated Galphas, could also be implicated in the induction of granulosa cell proliferation and seems to modulate the invasiveness of the tumor.
A network of G-protein signaling pathways control neuronal activity in C. elegans.
Nurrish et al., London, United Kingdom. In Adv Genet, 2008
At least four heterotrimeric G-proteins (Galphaq, Galpha12, Galphao, and Galphas) act within the motorneurons to control the activity of the NMJ.
Physiological dysfunctions associated with mutations of the imprinted Gnas locus.
Plagge et al., Liverpool, United Kingdom. In Physiology (bethesda), 2008
The Galphas-encoding locus Gnas is now known to consist of a complex arrangement of several protein-coding and noncoding transcripts.
High throughput screening for orphan and liganded GPCRs.
Young et al., San Francisco, United States. In Comb Chem High Throughput Screen, 2008
The strengths, weaknesses, and applications of assay technologies applicable to G alpha s, G alpha i and G alpha q-coupled receptors are described and their relative merits evaluated.
Structural basis of effector regulation and signal termination in heterotrimeric Galpha proteins.
Du et al., Dallas, United States. In Adv Protein Chem, 2006
Galphas is an allosteric activator and inhibitor of adenylyl cyclase, and Galphai is an allosteric inhibitor.
Erythrocyte G protein-coupled receptor signaling in malarial infection.
Haldar et al., Chicago, United States. In Science, 2003
We have found that signaling via the erythrocyte beta2-adrenergic receptor and heterotrimeric guanine nucleotide-binding protein (Galphas) regulated the entry of the human malaria parasite Plasmodium falciparum.
Src tyrosine kinase is a novel direct effector of G proteins.
Huang et al., New York City, United States. In Cell, 2000
Here we demonstrate that Galphas and Galphai, but neither Galphaq, Galpha12 nor Gbetay, directly stimulate the kinase activity of downregulated c-Src.
Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies.
O'Kane et al., United States. In Science, 1997
Expression of Galphas* did not affect gross MB morphology, and wild-type Galphas expression did not affect learning.
Inhibition of an inwardly rectifying K+ channel by G-protein alpha-subunits.
Dascal et al., Graz, Austria. In Nature, 1996
High-affinity but partial inhibition is produced by G alpha s-GTP gamma S. G alpha i 1-GTP gamma S also inhibits G beta 1 gamma 2-activated GIRK in atrial myocytes.
Suppression of Ras-induced transformation of NIH 3T3 cells by activated G alpha s.
Iyengar et al., New York City, United States. In Science, 1994
Interactions between G alpha s, the alpha subunit of the heterotrimeric guanine nucleotide binding protein that stimulates adenylyl cyclase, and Ras, an important element in growth factor signaling, were studied.
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