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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Guanine nucleotide binding protein

Galpha16, Galpha15
alpha subunit of an heterotrimeric G-protein; may function in taste signal transduction [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, Gi, Galphas, G16
Papers on Galpha16
Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq.
Rozengurt et al., Los Angeles, United States. In Cell Signal, 2012
This paper shows how G alpha 15 and other Gq class members phosphorylate PKD in differing patterns
Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling.
Wong et al., Hong Kong, Hong Kong. In Bmc Struct Biol, 2010
beta3 region of Galpha16 is essential for interaction with TPR1 and the subsequent activation of Ras
Galpha16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS).
Wong et al., Hong Kong, Hong Kong. In Cell Signal, 2010
Members of the Gq family of G proteins, in particular Galpha16, have been shown to associate with tetratricopeptide repeat 1 (TPR1), an adaptor protein which preferentially binds to Ras.
Galpha16 interacts with Class IA phosphatidylinositol 3-kinases and inhibits Akt signaling.
Wong et al., Hong Kong, Hong Kong. In Cell Signal, 2010
Phosphatidylinositol 3-kinase (PI3K) mediates receptor tyrosine kinase and G protein coupled receptor (GPCR) signaling by phosphorylating phosphoinositides to elicit various biological responses.
The puzzling uniqueness of the heterotrimeric G15 protein and its potential beyond hematopoiesis.
Innamorati et al., Monza, Italy. In J Mol Endocrinol, 2010
This review summarizes the specific features that distinguish Galpha15/GNA15 (G15 alpha subunit) from all other alpha subunits of the Gq class. G15 is a heterotrimeric G protein complex that is named after its alpha subunit.
CCR1-mediated activation of Nuclear Factor-kappaB in THP-1 monocytic cells involves Pertussis Toxin-insensitive Galpha(14) and Galpha(16) signaling cascades.
Wong et al., Hong Kong, Hong Kong. In J Leukoc Biol, 2009
The ability of CCR1 to signal through Galpha(14/16) thus provides a linkage for chemokines to regulate NF-kappaB-dependent responses.
Amiodarone and its putative metabolites fail to activate wild type hTAAR1.
Gilmour et al., United States. In Bioorg Med Chem Lett, 2009
Receptor activation was monitored by measuring the accumulation of cAMP, the putative hTAAR1 native second messenger, or calcium mobilization in cells where the receptor was coupled to the promiscuous Gq, Galpha16.
Development of generic calcium imaging assay for monitoring Gi-coupled receptors and G-protein interaction.
Shimada et al., Nagoya, Japan. In J Biomol Screen, 2009
Although chimeric Galpha16 proteins are valuable tools for detecting the activation of Galpha(i/o)-coupled receptors, the details of the activation process remain unclear.
Heterotrimeric G proteins demonstrate differential sensitivity to beta-arrestin dependent desensitization.
Parenti et al., Verona, Italy. In Cell Signal, 2009
The paper describes G alpha 15 resistance to arrestin-desensitization making it differ from other heterotrimeric G proteins (Gq, Gs, Gi, G12/13 class)
A hematopoietic perspective on the promiscuity and specificity of Galpha16 signaling.
Wong et al., Hong Kong, Hong Kong. In Neurosignals, 2008
Galpha(16), a member of G(q) subfamily, is expressed exclusively in hematopoietic cells, and its expression is highly modulated during lineage differentiation.
Differential involvement of Galpha16 in CC chemokine-induced stimulation of phospholipase Cbeta, ERK, and chemotaxis.
Wong et al., Durham, United States. In Cell Signal, 2008
Chemokines are known to regulate the chemotaxis of leukocytes and play an important role in immunological processes.
Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors.
Prinssen et al., Basel, Switzerland. In Br J Pharmacol, 2008
EXPERIMENTAL APPROACH: Enhancing properties of rac-BHFF were assessed in the Chinese hamster ovary (CHO)-Galpha16-hGABA(B1a,2a) cells by Fluorometric Imaging Plate Reader and GTPgamma[35S]-binding assays, and in rat hippocampal slices by population spike (PS) recordings.
Development of a universal high-throughput calcium assay for G-protein- coupled receptors with promiscuous G-protein Galpha15/16.
Xie et al., Shanghai, China. In Acta Pharmacol Sin, 2008
AIM: To develop a universal high-throughput screening assay based on Galpha15/16- mediated calcium mobilization for the identification of novel modulators of Gprotein- coupled receptors (GPCR).
Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors.
Roth et al., Cleveland, United States. In Biochemistry, 2008
To investigate this possibility, the effects of overexpressing Galpha-subunits (Galpha16 or Galphai2) with the kappa-opioid receptor (KOR) were examined.
Mutations on the Switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectors.
Wong et al., Hong Kong, Hong Kong. In J Mol Signal, 2007
BACKGROUND: Galpha16 can activate phospholipase Cbeta (PLCbeta) directly like Galphaq.
Functional identification of the stable transfection C5aR cell line Molt-4.
Li et al., Beijing, China. In Cell Mol Immunol, 2007
The complement C5 anaphylatoxin receptor is a member of the seven transmembrane-spanning G protein-coupled receptor superfamily that signals through Galphai and Galpha16.
Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase.
Wong et al., Hong Kong, Hong Kong. In J Biol Chem, 2006
In contrast to the Galpha16-mediated regulation of STAT3 in HEK 293 cells (Lo, R. K., Cheung, H., and Wong, Y. H. (2003) J. Biol.
Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade.
Wong et al., Hong Kong, Hong Kong. In Febs J, 2006
In human embryonic kidney 293 cells transiently expressing constitutively active mutants of G alpha11, G alpha14, G alpha16, G alpha12, or G alpha13 (G alpha11QL, G alpha14QL, G alpha16QL, G alpha12QL and G alpha13QL, respectively), basal phosphorylation of Akt was attenuated, as revealed by western blotting analysis using a phosphospecific anti-Akt immunoglobulin.
Is Galpha16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors?
Kostenis, Frankfurt am Main, Germany. In Trends Pharmacol Sci, 2001
One possibility that achieves such a 'universal assay' takes advantage of the promiscuous nature of the G-protein subunit Galpha16.
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