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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1

GalNAc-T, GM2/GD2 synthase, polypeptide N-acetylgalactosaminyltransferase, GalNAc transferase, GalNAc-T1, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, glycosyltransferase, HAD, CD45
Papers on GalNAc-T
Influenza A virus-induced expression of a GalNAc transferase, GALNT3, via miRNAs is required for enhanced viral replication.
New
Tomonaga et al., Kyoto, Japan. In J Virol, Jan 2016
In this study, we show that two miRNAs that target the UDP-GalNAc transferase GALNT3 are markedly decreased during the early stage of IAV infection, resulting in the upregulation of GALNT3 mRNA.
Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels.
New
Pan et al., Nanning, China. In Sci Rep, Dec 2015
This study was to determine the association between several single nucleotide polymorphisms (SNPs) in the dedicator of cytokinesis 7 (DOCK7), proprotein convertase subtilisin/kexin type 9 (PCSK9) and polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) and serum lipid levels.
Deconstruction of O-glycosylation-GalNAc-T isoforms direct distinct subsets of the O-glycoproteome.
New
Clausen et al., Copenhagen, Denmark. In Embo Rep, Dec 2015
Here, we used a zinc-finger nuclease (ZFN)-directed knockout strategy to probe the contributions of the major GalNAc-Ts (GalNAc-T1 and GalNAc-T2) in liver cells and explore how the GalNAc-T repertoire quantitatively affects the O-glycoproteome.
Mucin-type O-glycosylation is controlled by short- and long-range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase family.
New
Gerken et al., Copenhagen, Denmark. In Glycobiology, Dec 2015
UNASSIGNED: A large family of UDP-GalNAc:polypeptide GalNAc transferases (ppGalNAc-Ts) initiates and defines sites of mucin-type Ser/Thr-O-GalNAc glycosylation.
A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.
New
Schjoldager et al., Copenhagen, Denmark. In Proc Natl Acad Sci U S A, Dec 2015
Here, we systematically investigated the potential of site-specific O-glycosylation mediated by distinct polypeptide GalNAc-transferase (GalNAc-T) isoforms to coregulate ectodomain shedding mediated by the A Disintegrin And Metalloproteinase (ADAM) subfamily of proteases and in particular ADAM17.
GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma.
New
Zhang et al., Shenzhen, China. In Tumour Biol, Nov 2015
UNASSIGNED: GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis.
Review of tumoral calcinosis: A rare clinico-pathological entity.
Review
Sakr et al., Alexandria, Egypt. In World J Clin Cases, 2014
Two subtypes of the primary variety exist; a hyper-phosphatemic type with familial basis represented by mutations in GalNAc transferase 3 gene (GALNT3), KLOTHO or Fibroblast growth factor 23 (FGF23) genes, and a normo-phosphatemic type with growing evidence of underlying familial base represented by mutation in SAMD9 gene.
Complementary innate (anti-A-specific) IgM emerging from ontogenic O-GalNAc-transferase depletion: (Innate IgM complementarity residing in ancestral antigen completeness).
Review
Arend, Iowa City, United States. In Immunobiology, 2014
The murine anti-A certainly originates from a cell surface- or cell adhesion molecule, which in the course of germ cell development becomes devoid of O-GalNAc-transferase and is released into the circulation.
Site-specific protein O-glycosylation modulates proprotein processing - deciphering specific functions of the large polypeptide GalNAc-transferase gene family.
Review
Clausen et al., Copenhagen, Denmark. In Biochim Biophys Acta, 2012
Recently we have begun to uncover human diseases associated with deficiencies in GalNAc-T genes (GALNTs).
Association between circulating tumor cells and prognosis in patients with stage III melanoma with sentinel lymph node metastasis in a phase III international multicenter trial.
Impact
Hoon et al., Santa Monica, United States. In J Clin Oncol, 2012
Blood was assessed using a verified multimarker RT-qPCR assay (MART-1, MAGE-A3, and GalNAc-T) of melanoma-associated proteins.
Severe impairment of leukocyte recruitment in ppGalNAcT-1-deficient mice.
GeneRIF
Zarbock et al., Münster, Germany. In J Immunol, 2012
Polypeptide GalNAcT-1 plays a predominant role in leukocyte recruitment in vivo by attaching functionally relevant O-linked glycans to L-selectin ligands.
Essential roles of gangliosides in the formation and maintenance of membrane microdomains in brain tissues.
Review
Furukawa et al., Nagoya, Japan. In Neurochem Res, 2012
Immunoblotting of fractions separated by sucrose density gradient ultracentrifugation revealed that DAF and NCAM having GPI-anchors tended to disappear from the raft fraction with intensities of DKO > GM2/GD2 synthase KO > GD3 synthase KO > WT.
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.
Review
Tabak et al., Copenhagen, Denmark. In Glycobiology, 2012
The GalNAc-T family is the largest glycosyltransferase enzyme family covering a single known glycosidic linkage and it is highly conserved throughout animal evolution, although absent in bacteria, yeast and plants.
Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates.
GeneRIF
Nishimura et al., Sapporo, Japan. In Glycobiology, 2012
Utilizing unnatural glycopeptide substrates for GalNAc-T3 we demonstrated that the GalNAc-specific sugar recognition of the lectin domain regulates further glycosylation.
Impaired hippocampal long-term potentiation and failure of learning in β1,4-N-acetylgalactosaminyltransferase gene transgenic mice.
GeneRIF
Furukawa et al., Yamagata, Japan. In Glycobiology, 2011
Impaired hippocampal long-term potentiation and failure of learning in beta1,4-N-acetylgalactosaminyltransferase gene transgenic mice
miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.
Impact
Hernando et al., New York City, United States. In Cancer Cell, 2011
Ectopic expression of miR-30b/30d promoted the metastatic behavior of melanoma cells by directly targeting the GalNAc transferase GALNT7, resulted in increased synthesis of the immunosuppressive cytokine IL-10, and reduced immune cell activation and recruitment.
Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases.
GeneRIF
Tabak et al., Cleveland, United States. In J Biol Chem, 2011
each ppGalNAc T isoform may be uniquely sensitive to peptide sequence and overall charge, which together dictates the substrate sites that will be glycosylated
Dendritic morphology and spine density is not altered in motor cortex and dentate granular cells in mice lacking the ganglioside biosynthetic gene B4galnt1 - A quantitative Golgi cox study.
GeneRIF
Heffer et al., Zagreb, Croatia. In Coll Antropol, 2011
To define maturation of cortical neurons in mice lacking B4galnt1 we performed a morphological analysis of Golgi-Cox impregnated pyramidal neurons.
Prognostic significance of molecular upstaging of paraffin-embedded sentinel lymph nodes in melanoma patients.
Impact
Hoon et al., Santa Monica, United States. In J Clin Oncol, 2004
PE SLNs (n = 308) from these patients were sectioned and assessed by qRT for mRNA of four melanoma-associated genes: MART-1 (antigen recognized by T cells-1), MAGE-A3 (melanoma antigen gene-A3 family), GalNAc-T (beta1-->4-N-acetylgalactosaminyl-transferase), and Pax3 (paired-box homeotic gene transcription factor 3). RESULTS: Fifty-three (25%) patients had histopathology-positive SLNs by hemotoxylin and eosin and/or immunohistochemistry.
A pituitary N-acetylgalactosamine transferase that specifically recognizes glycoprotein hormones.
Impact
Baenziger et al., Saint Louis, United States. In Science, 1988
A GalNAc-transferase was identified in bovine pituitary membranes that recognizes features of the alpha-subunit peptide and adds GalNAc to its oligosaccharides with an apparent Michaelis constant of 25 micromolar.
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