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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

LGALS9 lectin, galactoside-binding, soluble, 9

galectin-9, ecalectin, Gal-9
a highly selective urate transporter/channel [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: galectin-1, Tim-3, CAN, CD4, HAD
Papers on galectin-9
Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.
New
Nishi et al., Japan. In J Biol Chem, Feb 2016
We previously showed that galectin-9 suppresses degranulation of mast cells through protein-glycan interaction with IgE.
Pattern of galectins expression in actinic cheilitis with different risks of malignant transformation.
New
da Silveira et al., Natal, Brazil. In J Oral Pathol Med, Jan 2016
METHODS: Immunoexpression of galectin-1, galectin-3, galectin-7, and galectin-9 was semiquantitatively analyzed in 65 cases of actinic cheilitis graded as low risk (n = 40) or high risk (n = 25) of malignant transformation.
Delayed ischemic preconditioning in the presence of galectin-9 protects against renal ischemic injury through a regulatory T-cell dependent mechanism.
New
Ding et al., Shanghai, China. In Nephrology (carlton), Dec 2015
Galectin-9 also attenuates inflammation-related organ injury by expanding Tregs, but it was not used in renal IR yet.
Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation.
Review
New
Blois et al., Berlin, Germany. In Am J Reprod Immunol, Dec 2015
METHOD OF STUDY: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats).
Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of Alcohol.
New
Day et al., Newcastle upon Tyne, United Kingdom. In Clin Gastroenterol Hepatol, Dec 2015
We investigated whether polymorphisms in the gene encoding galectin-9 (LGALS9), previously shown to mediate liver injury, were associated with the development of ALD.
A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression.
New
Impact
Akashi et al., Fukuoka, Japan. In Cell Stem Cell, Oct 2015
Here, we show that TIM-3 and its ligand, galectin-9 (Gal-9), constitute an autocrine loop critical for LSC self-renewal and development of human AML.
Galectin expression in cancer diagnosis and prognosis: A systematic review.
Review
New
Griffioen et al., Amsterdam, Netherlands. In Biochim Biophys Acta, Apr 2015
In most cancers, increased galectin-1 expression is associated with poor prognosis while elevated galectin-9 expression is emerging as a marker of favorable disease outcome.
[The present state and the future perspective of immunotherapy of renal cell carcinoma].
Review
Kawashima, In Nihon Rinsho, 2015
Our experimental research on galectin 9 and PINCH as promising immunotherapy targets is also mentioned.
Serum Galectin-9 Levels Are Associated with Coronary Artery Disease in Chinese Individuals.
Zhong et al., Wuhan, China. In Mediators Inflamm, 2014
Recently, several studies suggest that galectin-9 (Gal-9) might play a pivotal role in the pathogenesis of autoimmune diseases.
Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells.
Impact
Kuchroo et al., Boston, United States. In Immunity, 2014
The β-galactoside-binding protein galectin-9 is critical in regulating the immune response, but the mechanism by which it functions remains unclear.
T cells are Smad'ly in love with galectin-9.
Impact
Cummings, Atlanta, United States. In Immunity, 2014
(2014) report that galectin-9 is required for the formation and stability of iTreg cells.
The role of T cell immunoglobulin and mucin domain-3 in immune thrombocytopenia.
Review
Shan et al., Jinan, China. In Scand J Immunol, 2014
T cell immunoglobulin and mucin domain-3 (TIM-3), originally identified as a T helper (Th) 1-specific type I membrane protein, plays a vital role in Th1 immunity and tolerance induction through interaction with its ligand, galectin-9.
Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma.
Review
Troncoso et al., Buenos Aires, Argentina. In World J Gastroenterol, 2014
On the other hand, the "tandem-repeat-type" lectins galectin-8 and galectin-9 are down-regulated in tumor hepatocytes.
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.
Impact
Jinushi et al., Sapporo, Japan. In Nat Immunol, 2012
DC-derived TIM-3 suppressed innate immune responses through the recognition of nucleic acids by Toll-like receptors and cytosolic sensors via a galectin-9-independent mechanism.
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Impact
Kuchroo et al., Boston, United States. In Nat Med, 2012
Bat3 protects T helper type 1 (TH1) cells from galectin-9–mediated cell death and promotes both proliferation and proinflammatory cytokine production.
The impaired immune regulation of autoimmune hepatitis is linked to a defective galectin-9/tim-3 pathway.
GeneRIF
Longhi et al., London, United Kingdom. In Hepatology, 2012
Reduced levels of Tim-3 on CD4(pos) CD25(neg) effector cells and of Gal9 in T-regs contribute to impaired immunoregulation in autoimmune hepatitis by rendering effector cells less prone to T-reg control and T-regs less capable of suppressing.
Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.
GeneRIF
Blazar et al., Minneapolis, United States. In Blood, 2012
These studies are the first to show that the absence of Tim-3/gal-9 pathway interactions augments systemic graft versus host disease and regulatory T-cells contribute to it.
Tim-2 up-regulation and galectin-9-Tim-3 pathway activation in Th2-biased response in Schistosoma japonicum infection in mice.
GeneRIF
Song et al., Hefei, China. In Immunol Lett, 2012
We concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica.
Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection.
GeneRIF
Horton et al., Seattle, United States. In Blood, 2012
Soluble Gal-9 interacts with Tim-3 expressed on the surface of activated CD4(+) T cells. This leads to down-regulation of HIV-1 coreceptors and up-regulation of the cyclin-dependent kinase inhibitor p21.
Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice.
GeneRIF
Hirashima et al., Okayama, Japan. In Int Arch Allergy Immunol, 2011
Gal-9 negatively regulates Th2-mediated eosinophilic inflammation of the lung and Foxp3+ regulatory T cells might be involved in suppressing allergic inflammation
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