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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lectin, galactoside-binding, soluble, 3

galectin-3, Mac-2
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: galectin-1, CAN, HAD, AGE, V1a
Papers using galectin-3 antibodies
Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity
Greenberg Andrew S. et al., In Diabetes, 2005
... phospho-JNK (9251), AKT (9272), and phospho-Akt (9271) were obtained from Cell Signaling (Danvers, MA), and a MAC-2 (CL8942AP) antibody was obtained from Cedarlane (Burlington, ON, Canada) ...
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma
Fajas Lluis et al., In Human Molecular Genetics, 2004
... Anti-Mac-2 was purchased from eBioscience.
Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy
Alzohaili Opada et al., In Diagnostic Pathology, 2004
... Galectin 39C41:100HIER Citrate BufferLeica Microsystems ...
Papers on galectin-3
Predictive Value for Galectin 3 and Cardiotrophin 1 in Hemodialysis Patients.
Covic et al., Jászvásár, Romania. In Angiology, Feb 2016
The prognostic value of the new cardiac biomarkers, cardiotrophin 1 (CT-1) and galectin 3 (GAL-3), has not yet been defined in hemodialysis (HD) patients.
Galectin-3 in cardiac muscle and circulation of dogs with degenerative mitral valve disease.
Surachetpong et al., Thailand. In J Vet Cardiol, Feb 2016
OBJECTIVES: This study aimed to determine the association of cardiac fibrosis with the galectin-3 (Gal-3) expression, a fibrosis marker in the myocardium and to compare plasma Gal-3 levels in normal and degenerative mitral valve disease (DMVD) dogs.
Evaluation of Temporal Changes in Cardiovascular Biomarker Concentrations Improves Risk Prediction in an Elderly Population from the Community.
Lind et al., Uppsala, Sweden. In Clin Chem, Feb 2016
METHODS: We measured concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP), midregional proadrenomedullin, high-sensitivity cardiac troponin I, growth-differentiation factor-15 (GDF-15), soluble ST2 (sST2), and galectin-3 at baseline and 5 years later in 1016 elderly individuals participating in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.
Galectin-3: A Link between Myocardial and Arterial Stiffening in Patients with Acute Decompensated Heart Failure?
Puschita et al., Arad, Romania. In Arq Bras Cardiol, Feb 2016
Galectin-3 is a recently discovered biomarker that plays an important role in myocardial and vascular fibrosis and heart failure progression.
Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners.
Muramatsu, Nagoya, Japan. In J Biochem, Jan 2016
The carbohydrate portion of basigin is recognized by lectins, such as galectin-3 and E-selectin.
Role of Galectin-3 in Obesity and Impaired Glucose Homeostasis.
Pugliese et al., Roma, Italy. In Oxid Med Cell Longev, Dec 2015
Galectin-3 is an important modulator of several biological functions.
Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer.
Uchino et al., Boston, United States. In Tissue Barriers, Jul 2015
This review highlights advances made in understanding the contributions of galectin-3, a carbohydrate-binding protein with affinity toward β-galactosides, as a modulator of epithelial junction assembly and function.
Galectin-3 as a Potential Target to Prevent Cancer Metastasis.
AlSadek et al., United States. In Clin Med Insights Oncol, 2014
Galectin-3, a member of the β-galactoside-binding lectin family, is involved in fibrosis as well as cancer progression and metastasis, but the detailed mechanisms of its functions remain elusive.
Immune-phenotypical markers for the differential diagnosis of melanocytic lesions.
Cantile et al., Napoli, Italy. In Int J Clin Exp Pathol, 2014
Recently, the diagnostic power of galectin-3 was demonstrated in series of melanocytic lesions, with a strong increasing of expression in malignant lesions compared with benign lesions.
The utility of biomarker risk prediction score in patients with chronic heart failure.
Kruzliak et al., Ukraine. In Int J Clin Exp Med, 2014
Circulating levels of NT-pro brain natriuretic peptide (NT-pro-BNP), galectin-3, high-sensitivity C-reactive protein (hs-CRP), osteoprotegerin and its soluble receptor sRANKL, osteopontin, osteonectin, adiponectin, endothelial apoptotic microparticles (EMPs) and mononuclear progenitor cells (MPCs) were measured at baseline.
Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers.
Johannes et al., Paris, France. In Nat Cell Biol, 2014
Here, we found that a carbohydrate-binding protein, galectin-3 (Gal3), triggered the glycosphingolipid (GSL)-dependent biogenesis of a morphologically distinct class of endocytic structures, termed clathrin-independent carriers (CLICs).
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.
Cerutti et al., New York City, United States. In Science, 2013
Glycans associated with MUC2 imprinted DCs with anti-inflammatory properties by assembling a galectin-3-Dectin-1-FcγRIIB receptor complex that activated β-catenin.
Progress in molecular-based management of differentiated thyroid cancer.
Schlumberger et al., Baltimore, United States. In Lancet, 2013
Diagnostic molecular markers, such as RET-PTC, RAS, and BRAF(V600E) mutations; galectin 3; and a new gene expression classifier, are outstanding examples that have improved diagnosis of thyroid nodules.
Molecular recognition of the Thomsen-Friedenreich antigen-threonine conjugate by adhesion/growth regulatory galectin-3: nuclear magnetic resonance studies and molecular dynamics simulations.
Cudic et al., Port Saint Lucie, United States. In Biochemistry, 2012
The results obtained from this model of the avian orthologue of human galectin-3 will allow detailed interspecies comparison to give sequence deviations in phylogeny a structural and functional meaning.
The involvement of the spleen during chronic phase of Schistosoma mansoni infection in galectin-3-/- mice.
El-Cheikh et al., Rio de Janeiro, Brazil. In Histol Histopathol, 2012
Galectin-3 plays a role in splenic architecture, controlling distinct events such as apoptosis, macrophage activity, B cell differentiation and plasmacytogenesis in the course of S. mansoni infection.
Galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury.
Kriz et al., Québec, Canada. In J Neurosci, 2012
Together, our findings suggest that galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury.
The use of a combination of Ki-67, Galectin-3, and PTTG can distinguish the benign and malignant thyroid tumor.
Zhang et al., Ürümqi, China. In Clin Lab, 2011
The combination of Galectin-3 and PTTG is complementary as a diagnostic biomarker for patients with papillary carcinoma.
Usefulness of cytokeratin-19, galectin-3, and Hector Battifora mesothelial-1 in the diagnosis of benign and malignant thyroid nodules.
Zhang et al., China. In Clin Lab, 2011
combined use of CK19, Gal-3, and HBME-1 is of practical value in the diagnosis and differential diagnosis of benign and malignant thyroid nodules
Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses.
Thoulouze et al., Paris, France. In Nat Med, 2010
We show here that HTLV-1-infected T lymphocytes transiently store viral particles as carbohydrate-rich extracellular assemblies that are held together and attached to the cell surface by virally-induced extracellular matrix components, including collagen and agrin, and cellular linker proteins, such as tetherin and galectin-3.
Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study.
Italian Thyroid Cancer Study Group (ITCSG) et al., Roma, Italy. In Lancet Oncol, 2008
Galectin-3 test proposed here does not replace conventional FNA cytology, but may be complementary diagnostic method for those follicular nodules that remain indeterminate.
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