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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lectin, galactoside-binding, soluble, 1

galectin-1, Hes1, HPL, HBL, galectin
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: galectin-3, CAN, HAD, V1a, galectin-9
Papers using galectin-1 antibodies
Jasmonic acid control of GLABRA3 links inducible defense and trichome patterning in Arabidopsis
Howe Gregg A. et al., In Plant Physiology, 2008
... HPL gene but not additional transgenic copies of the cDNA ...
The anti-angiogenic peptide anginex disrupts the cell membrane
Yang K-D et al., In Cell Death & Disease, 2005
... Antibody to galectin-1 (H-45) was purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein
Zhu Xueliang et al., In The Journal of Cell Biology, 1998
... The full-length cDNA for hPL, also called chorionic somatomammotropin (Walker et al., 1991), was amplified by PCR from a placenta cDNA library (CLONTECH Laboratories, Inc.) and cloned ...
E. coli expression and purification of Fab antibody fragments.
Bunce Christopher, In PLoS ONE, 1990
... Human MCL cell lines JeKo-1 and HBL-2 were obtained from American Type Culture Collection (Manassas, VA) and maintained in RPMI 1640 (Invitrogen; Carlsbad, CA) supplemented with 10% (v/v) heat-inactivated FBS (Thermo Scientific; Logan, UT), 100 U/mL ...
Papers on galectin-1
Predictive Value for Galectin 3 and Cardiotrophin 1 in Hemodialysis Patients.
Covic et al., Jászvásár, Romania. In Angiology, Feb 2016
The prognostic value of the new cardiac biomarkers, cardiotrophin 1 (CT-1) and galectin 3 (GAL-3), has not yet been defined in hemodialysis (HD) patients.
Galectin-3 in cardiac muscle and circulation of dogs with degenerative mitral valve disease.
Surachetpong et al., Thailand. In J Vet Cardiol, Feb 2016
OBJECTIVES: This study aimed to determine the association of cardiac fibrosis with the galectin-3 (Gal-3) expression, a fibrosis marker in the myocardium and to compare plasma Gal-3 levels in normal and degenerative mitral valve disease (DMVD) dogs.
Endoplasmic reticulum (ER)-targeted, galectin-mediated retrograde transport using a HaloTag carrier protein.
Kanie et al., Japan. In Chembiochem, Feb 2016
To translocate compounds from outside cells into the endoplasmic reticulum (ER), we constructed a delivery carrier protein, comprising N-terminal galectin-1 for cell-surface binding (G1), a protease cleavable sequence (ps), a HaloTag domain for carrying exogenous compounds (Halo), and a C-terminal KDEL sequence for ER retention.
Mesenchymal Stem Cells Inhibit Transmission of α-Synuclein by Modulating Clathrin-Mediated Endocytosis in a Parkinsonian Model.
Lee et al., Seoul, South Korea. In Cell Rep, Feb 2016
Furthermore, we identify that galectin-1, a soluble factor derived from MSCs, played an important role in the transmission control of aggregated α-synuclein in these models.
Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners.
Muramatsu, Nagoya, Japan. In J Biochem, Jan 2016
The carbohydrate portion of basigin is recognized by lectins, such as galectin-3 and E-selectin.
Role of Galectin-3 in Obesity and Impaired Glucose Homeostasis.
Pugliese et al., Roma, Italy. In Oxid Med Cell Longev, Dec 2015
Galectin-3 is an important modulator of several biological functions.
Clinical significance of galectin-7 in vulvar squamous cell carcinoma.
Wu et al., Shenyang, China. In Oncol Lett, Dec 2015
UNASSIGNED: The present study reports the role of galectin-7 (Gal-7) expression in vulvar squamous cell carcinoma (VSCC) and its correlation with clinicopathological variables.
A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression.
Akashi et al., Fukuoka, Japan. In Cell Stem Cell, Oct 2015
Here, we show that TIM-3 and its ligand, galectin-9 (Gal-9), constitute an autocrine loop critical for LSC self-renewal and development of human AML.
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.
Ivashkiv et al., New York City, United States. In Nat Immunol, Aug 2015
Physiological downregulation of mTORC1 by IFN-γ was associated with autophagy and translational suppression of repressors of inflammation such as HES1.
Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.
Conejo-Garcia et al., Philadelphia, United States. In Cancer Cell, Feb 2015
Mechanistically, expanded granulocytic MDSCs cause γδ lymphocytes in TLR5-responsive tumors to secrete galectin-1, dampening antitumor immunity and accelerating malignant progression.
Galectin-3 as a Potential Target to Prevent Cancer Metastasis.
AlSadek et al., United States. In Clin Med Insights Oncol, 2014
Galectin-3, a member of the β-galactoside-binding lectin family, is involved in fibrosis as well as cancer progression and metastasis, but the detailed mechanisms of its functions remain elusive.
Immune-phenotypical markers for the differential diagnosis of melanocytic lesions.
Cantile et al., Napoli, Italy. In Int J Clin Exp Pathol, 2014
Recently, the diagnostic power of galectin-3 was demonstrated in series of melanocytic lesions, with a strong increasing of expression in malignant lesions compared with benign lesions.
First trimester serum tests for Down's syndrome screening.
Alfirevic et al., Liverpool, United Kingdom. In Cochrane Database Syst Rev, 2014
We evaluated 78 test combinations formed from combinations of 18 different tests, with or without maternal age; ADAM12 (a disintegrin and metalloprotease), AFP (alpha-fetoprotein), inhibin, PAPP-A (pregnancy-associated plasma protein A, ITA (invasive trophoblast antigen), free βhCG (beta human chorionic gonadotrophin), PlGF (placental growth factor), SP1 (Schwangerschafts protein 1), total hCG, progesterone, uE3 (unconjugated oestriol), GHBP (growth hormone binding protein), PGH (placental growth hormone), hyperglycosylated hCG, ProMBP (proform of eosinophil major basic protein), hPL (human placental lactogen), (free αhCG, and free ßhCG to AFP ratio.
Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells.
Kuchroo et al., Boston, United States. In Immunity, 2014
The β-galactoside-binding protein galectin-9 is critical in regulating the immune response, but the mechanism by which it functions remains unclear.
T cells are Smad'ly in love with galectin-9.
Cummings, Atlanta, United States. In Immunity, 2014
(2014) report that galectin-9 is required for the formation and stability of iTreg cells.
Galectin-1 in melanoma biology and related neo-angiogenesis processes.
Feron et al., Brussels, Belgium. In J Invest Dermatol, 2012
It was shown that the highly expressed galectin 1 in aggressive melanoma actively participates in metastasis. A role was shown for galectin 1 in the senescence of lung microvascular endothelial cells at the metastatic site.
GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis.
Milot et al., Montréal, Canada. In Mol Cell Biol, 2012
results describe a mechanism whereby GATA-1 utilizes Ikaros and Polycomb repressive complex 2 to promote Hes1 repression as an important step in erythroid cell differentiation
Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration.
Rabinovich et al., Boston, United States. In Immunity, 2012
Galectin-1 is a pivotal regulator of M1 microglial activation that targets the activation of p38MAPK-, CREB-, and NF-kB-dependent signaling pathways and hierarchically suppresses downstream proinflammatory mediators, such as iNOS, TNF, and CCL2.
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.
Zúñiga-Pflücker et al., Toronto, Canada. In Blood, 2012
These results point to HES1, via repression of PTEN, and c-Myc as critical mediators of Notch function at the beta-selection checkpoint.
Galectin-1 is up-regulated by RASSF1A gene in human gastric carcinoma cell line SGC7901.
Jian-Hua et al., Changsha, China. In Apmis, 2012
Galectin-1 may play a role in RASSF1A signaling in a gastric neoplams cell line.
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