High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.
New York City, United States. In Mod Pathol, Feb 2016
Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN).
In vitro toxicity of the galanin receptor 3 antagonist SNAP 37889.
Salzburg, Austria. In Neuropeptides, Jan 2016
Our experiments revealed that SNAP 37889 (≥10μM) induced apoptosis in epithelial (HMCB) and microglial (BV-2) cell lines expressing endogenous GAL3, in peripheral blood mononuclear cells and promyelocytic leukemia cells (HL-60) expressing GAL2, and in a neuronal cell line (SH-SY5Y) lacking galanin receptor expression altogether.
Galanin receptor-expressing dorsal horn neurons: role in nociception.
Nashville, United States. In Neuropeptides, 2011
Data show that destruction of GalR1-expressing superficial dorsal horn neurons produces heat hypoalgesia, likely due to loss of GalR1-expressing excitatory interneurons leading to reduced activation of nociceptive projection neurons in response to heat.