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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Galanin receptor 1

galanin receptor, GalR1, galanin receptor 1
G-protein coupled receptor that binds the neuropeptide galanin; inhibits cAMP formation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Neuropeptide, GalR2, V1a, ACID, GalR3
Papers on galanin receptor
High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.
New
Sepulveda et al., New York City, United States. In Mod Pathol, Feb 2016
Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN).
Type 2 diabetes mellitus as a disorder of galanin resistance.
Review
New
Zhang et al., Taizhou, China. In Exp Gerontol, Jan 2016
Hyperglycemia, hyperinsulinism, enhanced plasma galanin levels and decreased galanin receptor activities are some of the characters of type 2 diabetes mellitus.
Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.
New
Gribble et al., Cambridge, United Kingdom. In Br J Pharmacol, Jan 2016
KEY RESULTS: Galanin receptor 1 (Galr1) and GIRK channel 1 (Kir 3.1, Kcnj3) and 4 (Kir 3.4, Kcnj5) mRNA expression was highly enriched in K and L cells.
Pharmacological stimulation of GAL1R but not GAL2R attenuates kainic acid-induced neuronal cell death in the rat hippocampus.
New
Langel et al., Stockholm, Sweden. In Neuropeptides, Jan 2016
In order to test the pharmaceutical potential of galanin receptor subtype selective ligands to inhibit excitotoxic cell death, the GAL1R selective ligand M617 and the GAL2R selective ligand M1145 were compared to the novel GAL1/2R ligand M1154, in their ability to reduce the excitotoxic effects of intracerebroventricular injected kainate acid in rats.
In vitro toxicity of the galanin receptor 3 antagonist SNAP 37889.
New
Kofler et al., Salzburg, Austria. In Neuropeptides, Jan 2016
Our experiments revealed that SNAP 37889 (≥10μM) induced apoptosis in epithelial (HMCB) and microglial (BV-2) cell lines expressing endogenous GAL3, in peripheral blood mononuclear cells and promyelocytic leukemia cells (HL-60) expressing GAL2, and in a neuronal cell line (SH-SY5Y) lacking galanin receptor expression altogether.
Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.
Review
New
Holmes et al., Atlanta, United States. In Brain Res, Dec 2015
We propose a model in which LC-derived galanin has two distinct functions: as a neuromodulator, primarily acting via the galanin 1 receptor (GAL1), and as a trophic factor, primarily acting via galanin receptor 2 (GAL2).
Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.
New
Mineta et al., Hamamatsu, Japan. In Clin Exp Metastasis, Dec 2015
UNASSIGNED: The aim of this study was to investigate the prognostic value of galanin (GAL) and galanin receptor (GALR) promoter hypermethylation in patients with head and neck squamous cell carcinoma (HNSCC).
Antinociceptive effects induced by intra-lateral habenula complex injection of the galanin receptor 1 agonist M617 in rats.
New
Zhuang et al., Changchun, China. In Exp Brain Res, Dec 2015
UNASSIGNED: The present study was performed to explore the antinociceptive effects of the galanin receptor 1 agonist M617 in lateral habenula complex in rats.
Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons.
New
Münzberg et al., Baton Rouge, United States. In Mol Metab, Oct 2015
Further, expression of galanin and its receptor GalR1 are decreased in the LHA of GAL-LepRb(KO) mice, resulting in increased activation of orexin neurons.
G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer?
Review
New
Carey et al., Japan. In Toxins (basel), Aug 2015
In this review, we discuss the roles that galanin receptor type 1 (GALR1) and type 2 (GALR2), tachykinin receptor type 1 (TACR1), and somatostatin receptor type 1 (SST1) play in HNSCC.
A Pyrosequencing Assay for the Quantitative Methylation Analysis of GALR1 in Endometrial Samples: Preliminary Results.
Karakitsos et al., Athens, Greece. In Biomed Res Int, 2014
We developed a new pyrosequencing assay that quantifies DNA methylation of galanin's receptor-1 (GALR1).
[Galanin-like peptide (GALP): localization, receptors and biological function].
Review
Ciosek et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2014
The effects of GALP are mediated by well-characterized G-protein coupled galanin receptor subtypes.
Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity.
Review
Impact
Kofler et al., Salzburg, Austria. In Pharmacol Rev, 2014
In this review, we emphasize the importance of novel galanin receptor-specific agonists and antagonists.
Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens.
Impact
Malenka et al., Stanford, United States. In Science, 2014
Here, we demonstrate that the decreased motivation elicited in mice by two different models of chronic pain requires a galanin receptor 1-triggered depression of excitatory synaptic transmission in indirect pathway nucleus accumbens medium spiny neurons.
Galanin negatively modulates opiate withdrawal via galanin receptor 1.
GeneRIF
Zachariou et al., Bristol, United Kingdom. In Psychopharmacology (berl), 2012
Galanin opposes the actions of morphine which leads to opiate dependence and withdrawal, an effect that is mediated via GalR1
Changes in galanin and GalR1 gene expression in discrete brain regions after transient occlusion of the middle cerebral artery in female rats.
GeneRIF
Theodorsson et al., Linköping, Sweden. In Neuropeptides, 2012
Transient occlusion of the middle cerebral artery altered GalR1 gene expression in rat brain supportting the notion that GalR1 may play a role in the response of the central nervous system to injury.
Galanin receptor-expressing dorsal horn neurons: role in nociception.
GeneRIF
Wiley et al., Nashville, United States. In Neuropeptides, 2011
Data show that destruction of GalR1-expressing superficial dorsal horn neurons produces heat hypoalgesia, likely due to loss of GalR1-expressing excitatory interneurons leading to reduced activation of nociceptive projection neurons in response to heat.
Expression of galanin and galanin receptor mRNA in skin during the formation of granulation tissue.
GeneRIF
Hoshino et al., Shizuoka, Japan. In Endocrine, 2011
This study found that GALR1 mRNA was expressed in granulation tissue, including in pericytes, but only in pericytes that had been dissociated from endothelial cells.
The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence.
GeneRIF
Damaj et al., Richmond, United States. In Neuropsychopharmacology, 2011
Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence.
Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo.
Impact
Langel et al., Stockholm, Sweden. In Nat Biotechnol, 1998
We show that a 21-mer PNA, complementary to the human galanin receptor type 1 mRNA, coupled to the cellular transporter peptides, transportan or pAntennapedia(43-58), is efficiently taken up into Bowes cells where they block the expression of galanin receptors.
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