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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2016.

GAL1 Gal1p

galactokinase, GAL1
Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, lacZ, GAL4
Papers using galactokinase antibodies
Altered mating-type identity in the fungus Podospora anserina leads to selfish nuclei, uniparental progeny and haploid meiosis
Supplier
Vilas-Boas Adlane et al., In Genetics and Molecular Biology, 1994
... GAL1-HIS3) strains (Clontech Laboratories, Inc.) were used ...
Papers on galactokinase
Enantioselective synthesis of vicinal (R,R)-diols by yeast butanediol dehydrogenase.
New
Biosca et al., Montpellier, France. In Appl Environ Microbiol, Feb 2016
We have also developed a new variant of the "delitto perfetto" methodology to place BDH1 under the control of the GAL1 promoter, resulting in a yeast strain that overexpresses butanediol dehydrogenase and formate dehydrogenase activities in the presence of galactose and regenerates NADH in the presence of formate.
Galanin microinjection into the dorsal periaqueductal gray matter produces paradigm-dependent anxiolytic effects.
New
Beijamini et al., Vitória, Brazil. In Brain Res Bull, Feb 2016
The actions of galanin are mediated by three types of metabotropic receptors: GAL1, GAL2, and GAL3.
Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.
New
Gribble et al., Cambridge, United Kingdom. In Br J Pharmacol, Jan 2016
Galanin and a selective GAL1 receptor agonist (M617) potently inhibited GLP-1 and GIP secretion from primary small intestinal cultures.
Pharmacological stimulation of GAL1R but not GAL2R attenuates kainic acid-induced neuronal cell death in the rat hippocampus.
New
Langel et al., Stockholm, Sweden. In Neuropeptides, Jan 2016
Galanin exerts its biological activity through three G-protein coupled receptor subtypes, GAL1-3R.
In vitro toxicity of the galanin receptor 3 antagonist SNAP 37889.
New
Kofler et al., Salzburg, Austria. In Neuropeptides, Jan 2016
UNASSIGNED: Galanin and its receptors (GAL1, GAL2, GAL3) modulate a range of neuronal, immune and vascular activities.
In Vivo Real-Time Control of Gene Expression: A Comparative Analysis of Feedback Control Strategies in Yeast.
New
di Bernardo et al., Pozzuoli, Italy. In Acs Synth Biol, Jan 2016
We chose as an experimental testbed the most commonly used inducible promoter in yeast: the galactose-responsive GAL1 promoter.
Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.
Review
New
Holmes et al., Atlanta, United States. In Brain Res, Dec 2015
We propose a model in which LC-derived galanin has two distinct functions: as a neuromodulator, primarily acting via the galanin 1 receptor (GAL1), and as a trophic factor, primarily acting via galanin receptor 2 (GAL2).
Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity.
Review
Impact
Kofler et al., Salzburg, Austria. In Pharmacol Rev, 2014
Galanin has been shown to regulate its numerous physiologic and pathophysiological processes through interactions with three G protein-coupled receptors, GAL1, GAL2, and GAL3, and signaling via multiple transduction pathways, including inhibition of cAMP/PKA (GAL1, GAL3) and stimulation of phospholipase C (GAL2).
Evolution of moonlighting proteins: insight from yeasts.
Review
Gancedo et al., Madrid, Spain. In Biochem Soc Trans, 2014
It focuses on data available on hexokinase from Saccharomyces cerevisiae that moonlights in catabolite repression and on galactokinase from Kluyveromyces lactis that moonlights controlling the induction of the GAL genes.
A negative feedback loop at the nuclear periphery regulates GAL gene expression.
GeneRIF
Weis et al., Berkeley, United States. In Mol Biol Cell, 2012
Localization to the nuclear periphery was found to dampen initial GAL gene induction and was required for rapid repression after gene inactivation, revealing a function for the nuclear periphery in repressing endogenous GAL gene expression.
Antagonistic gene transcripts regulate adaptation to new growth environments.
GeneRIF
Hasty et al., San Diego, United States. In Proc Natl Acad Sci U S A, 2012
The spatial regulation of GAL1 and CLN3 transcripts is what allows growth to be maintained during fluctuations of glucose availability.
The effect of a Pro²⁸Thr point mutation on the local structure and stability of human galactokinase enzyme-a theoretical study.
GeneRIF
Viskolcz et al., Szeged, Hungary. In J Mol Model, 2011
A possible mechanism for the unfolding caused by the Pro(28)Thr point mutation of human galactokinase.
A RSC/nucleosome complex determines chromatin architecture and facilitates activator binding.
Impact
Ptashne et al., New York City, United States. In Cell, 2010
Taken with our previous work, the results show that both prior to and following induction, specific DNA-binding proteins are the predominant determinants of chromatin architecture at the GAL1/10 genes.
Autosomal recessive congenital cataract in consanguineous Pakistani families is associated with mutations in GALK1.
GeneRIF
Riazuddin et al., Lahore, Pakistan. In Mol Vis, 2009
Pathogenic mutations in GALK1 that are responsible for autosomal recessive congenital cataracts in consanguineous Pakistani families, are reported.
Epigenetics of the yeast galactose genetic switch.
Review
Iyer et al., Mumbai, India. In J Biosci, 2009
The redundancy in signal transduction due to the presence of GAL1 (alternate signal transducer) also makes it a suitable model to understand the phenomenon of epigenetics.
A tale of coupling, Sus1 function in transcription and mRNA export.
Review
Rodríguez-Navarro et al., Valencia, Spain. In Rna Biol, 2009
Being a factor shared by these two complexes, Sus1 physically link the activated GAL1 gene to the nuclear periphery, which constitute a determinant of regulation.
A novel c.-22T>C mutation in GALK1 promoter is associated with elevated galactokinase phenotype.
GeneRIF
Song et al., Anyang, South Korea. In Bmc Med Genet, 2008
These results suggest that the elevated GALK1 activity resulted from enhanced gene expression, due to nucleotide variation within GALK1 promoter
Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export.
Impact
Hurt et al., Heidelberg, Germany. In Nat Cell Biol, 2008
Loss of Sgf73 from SAGA abrogates gene gating of GAL1 and causes a GAL1 mRNA export defect.
Targeted pre-mRNA modification for gene silencing and regulation.
Impact
Yu et al., Rochester, United States. In Nat Methods, 2008
Saccharomyces cerevisiae expressing this guide RNA gene controlled by a GAL1 promoter grew normally on dextrose but not on galactose medium.
Gene duplication and the adaptive evolution of a classic genetic switch.
Impact
Carroll et al., Madison, United States. In Nature, 2007
The genetic switch controlling the yeast galactose use pathway includes two paralogous genes in Saccharomyces cerevisiae that encode a co-inducer (GAL3) and a galactokinase (GAL1).
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