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Galactose-3-O-sulfotransferase 2

Gal3ST-2, GP3ST, Gal3ST-3, a Gal 3-O-sulphotransferase
This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on Gal3ST-2
Porcine, mouse and human galactose 3-O-sulphotransferase-2 enzymes have different substrate specificities; the porcine enzyme requires basic compounds for its catalytic activity.
GeneRIF
Yamashita et al., Tokyo, Japan. In Biochem J, 2005
The substrate specificity and cofactor requirements of human, porcine, and murine GAL3ST are reported
Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins.
GeneRIF
Wu et al., Shanghai, China. In Biochem Biophys Res Commun, 2005
Gal3ST-2 is involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrin alphaV but not beta3
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