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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Regulator of G-protein signaling 19

GAIP, RGS19, Galpha-interacting protein
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RGS, NIP, RGS4, CAN, ACID
Papers on GAIP
A GIPC1-palmitate switch modulates dopamine Drd3 receptor trafficking and signaling.
Jeanneteau et al., Montpellier, France. In Mol Cell Biol, Feb 2016
We tested this model in cellulo using the interaction of Drd3 with the GAIP- interacting protein C-terminus-1 (GIPC1) as a template.
The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Chen et al., Winston-Salem, United States. In Neuroscience, Nov 2015
AMPH self-administration also produced a negative correlation of the mRNA levels of RGS7 and RGS19 between the two brain regions, which was not present in the control group.
RGS19 converts iron deprivation stress into a growth-inhibitory signal.
Lee et al., Taegu, South Korea. In Biochem Biophys Res Commun, Sep 2015
DFO protected RGS19 from proteolysis induced by GAIP interacting protein N terminus (GIPN); moreover, an iron-deficient RGS19 mutant was stable in the presence of GIPN and retained GTPase-activating protein activity.
Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression.
Chu et al., Harbin, China. In Br J Pharmacol, Aug 2015
Interactions between TGFBR3 and the scaffolding protein, GAIP-interacting protein C-terminus (GIPC) were detected using co-immunoprecipitation (co-IP).
CD93 and GIPC expression and localization during central nervous system inflammation.
Zhang et al., Nantong, China. In Neural Regen Res, 2014
CD93 and GAIP-interacting protein, C termius (GIPC) have been shown to interactively alter phagocytic processes of immune cells.
Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth.
Mukhopadhyay et al., New Delhi, India. In Mol Cancer Ther, 2014
Endoglin, a 180-kDa disulfide-linked homodimeric transmembrane receptor protein mostly expressed in tumor-associated endothelial cells, is an endogenous binding partner of GAIP-interacting protein, C terminus (GIPC).
GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.
Mukhopadhyay et al., Rochester, United States. In Plos One, 2013
GAIP interacting protein C terminus (GIPC) is known to play an important role in a variety of physiological and disease states.
Functional proteomics, human genetics and cancer biology of GIPC family members.
Katoh, Tokyo, Japan. In Exp Mol Med, 2012
The PDZ domain of GIPC1 is involved in interactions with transmembrane proteins [IGF1R, NTRK1, ADRB1, DRD2, TGFβR3 (transforming growth factorβ receptor type III), SDC4, SEMA4C, LRP1, NRP1, GLUT1, integrin α5 and VANGL2], cytosolic signaling regulators (APPL1 and RGS19) and viral proteins (HBc and HPV-18 E6).
Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum.
Wong et al., Hong Kong, Hong Kong. In Mol Cell Biochem, 2012
elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases
RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling.
Wong et al., Hong Kong, Hong Kong. In Cancer Lett, 2011
cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced
RGS19 enhances cell proliferation through its C-terminal PDZ motif.
Wong et al., Hong Kong, Hong Kong. In Cell Signal, 2010
Regulator of G protein signaling 19 enhances cell proliferation through binding to GAIP-interacting protein C-terminus.
Effects of regulator of G protein signaling 19 (RGS19) on heart development and function.
Ryoo et al., Taegu, South Korea. In J Biol Chem, 2010
RGS19 influenced cardiac development and had negative effects on heart function.
RGS19 regulates Wnt-beta-catenin signaling through inactivation of Galpha(o).
Malbon et al., Stony Brook, United States. In J Cell Sci, 2007
Results suggest a complex role for RGS19 in regulating the ability of Wnt3a to signal to the level of beta-catenin and gene transcription.
RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling.
Albert et al., London, Canada. In Semin Cell Dev Biol, 2006
The RZ/A family includes RGSZ2/RGS17 (the most recently discovered member of this family), GAIP/RGS19, RGSZ1/RGS20, and the RGSZ1 variant Ret-RGS.
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors.
Muallem et al., Dallas, United States. In Nat Cell Biol, 2005
SPL also binds RGS1, RGS4, RGS16 and GAIP.
Regulation of chemokine-induced lymphocyte migration by RGS proteins.
Kehrl et al., Bethesda, United States. In Methods Enzymol, 2003
Among RGS proteins with the highest levels of expression are RGS1, RGS2, RGS10, RGS13, RGS14, RGS16, and RGS19.
GIPC gene family (Review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
PDZ domain of GIPC family proteins interact with Frizzled-3 (FZD3) class of WNT receptor, insulin-like growth factor-I (IGF1) receptor, receptor tyrosine kinase TrkA, TGF-beta type III receptor (TGF-beta RIII), integrin alpha6A subunit, transmembrane glycoprotein 5T4, and RGS19/RGS-GAIP.
Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits.
Ross et al., Dallas, United States. In Science, 1997
Palmitoylation of Galphaz also inhibited its response to the GAP activity of Galpha-interacting protein (GAIP), another RGS protein, and palmitoylation of Galphai1 inhibited its response to RGS4.
RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.
Blumer et al., Saint Louis, United States. In Nature, 1996
RGS1, RGS4 and GAIP (for G alpha-interacting protein) bind specifically and tightly to G alphai and G alpha0 in cell membranes treated with GDP and AlF4(-), and are GAPs for G alphai, G alpha0 and transducin alpha-subunits, but not for G alphas.
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.
Gilman et al., Dallas, United States. In Cell, 1996
We have found that two RGS family members, GAIP and RGS4, are GTPase-activating proteins (GAPs), accelerating the rate of GTP hydrolysis by Gi alpha 1 at least 40-fold.
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