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Growth arrest and DNA-damage-inducible, alpha

GADD45, Gadd45a, GADD45alpha
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010] (from NCBI)
Papers on GADD45
Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy.
Adams et al., Iowa City, United States. In J Biol Chem, 2012
Gadd45a reduces multiple barriers to muscle atrophy (including PGC-1alpha, Akt activity, and protein synthesis) and stimulates pro-atrophy mechanisms (including autophagy and caspase-mediated proteolysis).
Gadd45a transcriptional induction elicited by the Aurora kinase inhibitor MK-0457 in Bcr-Abl-expressing cells is driven by Oct-1 transcription factor.
Santucci et al., Bologna, Italy. In Leuk Res, 2012
AK inhibitor MK-0457 induces the growth arrest DNA damage-inducible (Gadd) 45a through recruitment of octamer-binding (Oct)-1 transcription factor at a critical promoter region for gene transcription and covalent modifications of histone H3.
NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression.
Welte et al., Hannover, Germany. In Biochem Biophys Res Commun, 2012
the increased expression of GADD45A under the above experimental conditions, NAMPT inhibition by FK866, involves acetylation of FOXO3a, a member of the important family of forkhead (FOXO) proteins.
Kinetics of GADD45α, TP53 and CASP3 gene expression in the rat lens in vivo in response to exposure to double threshold dose of UV-B radiation.
Söderberg et al., Stockholm, Sweden. In Exp Eye Res, 2012
A transient upregulation of the stress sensor GADD45alpha, a concurrent downregulation of TP53 and CASP3, followed by a constant upregulation of TP53 that precedes a constant upregulation of CASP3.
Overexpression of DNA damage-induced 45 α gene contributes to esophageal squamous cell cancer by promoter hypomethylation.
Yin et al., Changsha, China. In J Exp Clin Cancer Res, 2011
Overexpression of DNA damage-induced 45 alpha gene contributes to esophageal squamous cell cancer by promoter hypomethylation
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