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proteins. Page last changed on 08 Dec 2016.
Growth arrest and DNA-damage-inducible, alpha
GADD45, Gadd45a, GADD45alpha
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010] (from
Adams et al., Iowa City, United States. In J Biol Chem, 2012
Gadd45a reduces multiple barriers to muscle atrophy (including PGC-1alpha, Akt activity, and protein synthesis) and stimulates pro-atrophy mechanisms (including autophagy and caspase-mediated proteolysis).
Santucci et al., Bologna, Italy. In Leuk Res, 2012
AK inhibitor MK-0457 induces the growth arrest DNA damage-inducible (Gadd) 45a through recruitment of octamer-binding (Oct)-1 transcription factor at a critical promoter region for gene transcription and covalent modifications of histone H3.