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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


GABARAP, GABA(A) receptor-associated protein
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rdl, ACID, LC3, Atg8, CAN
Papers on GABARAP
Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation.
Alonso et al., Bilbao, Spain. In Biophys J, Feb 2016
Here, we used two minimal reconstituted systems (enzymatic and chemical conjugation) to compare the ability of human ATG8 homologs (LC3, GABARAP, and GATE-16) to mediate membrane fusion.
Ubiquitin-Dependent And Independent Signals In Selective Autophagy.
Dikic et al., Frankfurt am Main, Germany. In Trends Cell Biol, Jan 2016
Autophagy receptors bind to LC3/GABARAP proteins on phagophore and autophagosome membranes, and recognize signals on cargoes to deliver them to autophagy.
The two Dictyostelium autophagy eight proteins, ATG8a and ATG8b, associate with the autophagosome in succession.
Eichinger et al., Köln, Germany. In Eur J Cell Biol, Jan 2016
We infer from our data that Dictyostelium ATG8a and ATG8b have distinct functions in autophagosome formation and that ATG8b is the functional orthologue of the mammalian LC3 subfamily and ATG8a of the GABARAP subfamily.
Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130.
Tooze et al., London, United Kingdom. In Mol Cell, Jan 2016
WAC and GM130 interact with the Atg8 homolog GABARAP and regulate its subcellular localization.
Analysis of the native conformation of the LIR/AIM motif in the Atg8/LC3/GABARAP-binding proteins.
Klionsky et al., Ann Arbor, United States. In Autophagy, Nov 2015
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy).
Stiff-person syndrome: insights into a complex autoimmune disorder.
Jankovic et al., Houston, United States. In J Neurol Neurosurg Psychiatry, Aug 2015
Antibodies directed against GABA(A) receptor-associated protein, and the glycine-α1 receptor can also be observed.
Regulation of endoplasmic reticulum turnover by selective autophagy.
Dikic et al., Frankfurt am Main, Germany. In Nature, Jul 2015
Here we show that members of the FAM134 reticulon protein family are ER-resident receptors that bind to autophagy modifiers LC3 and GABARAP, and facilitate ER degradation by autophagy ('ER-phagy').
Protein-protein interaction networks identify targets which rescue the MPP(+) cellular model of Parkinson's disease.
Wade-Martins et al., Oxford, United Kingdom. In Sci Rep, 2014
Analysis of protein-protein interaction networks constructed to model the interplay of mitochondrial dysfunction and autophagic dysregulation (key aspects of MPP(+) toxicity) enabled us to identify four proteins predicted to be key for MPP(+) toxicity (P62, GABARAP, GBRL1 and GBRL2).
Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.
Melia et al., New Haven, United States. In Nat Cell Biol, 2014
Here we demonstrate that the E2-like enzyme, Atg3, facilitates LC3/GABARAP lipidation only on membranes exhibiting local lipid-packing defects.
The LC3 interactome at a glance.
Dikic et al., Frankfurt am Main, Germany. In J Cell Sci, 2014
In higher eukaryotes, the Atg8 family comprises six members known as the light chain 3 (LC3) or γ-aminobutyric acid (GABA)-receptor-associated protein (GABARAP) proteins.
In vitro assays of lipidation of Mammalian atg8 homologs.
Kominami et al., Tokyo, Japan. In Curr Protoc Cell Biol, 2013
Mammalian Atg8 homologs (Atg8s) including LC3, GABARAP, and GATE-16, are also ubiquitin-like modifiers.
Regulation and functional roles of rebound potentiation at cerebellar stellate cell-Purkinje cell synapses.
Kawaguchi et al., Kyoto, Japan. In Front Cell Neurosci, 2013
RP induction depends on binding of GABAAR with GABAAR associated protein (GABARAP) which is regulated by Ca(2+)/calmodulin-dependent kinase II (CaMKII).
Doxorubicin-induced glomerulosclerosis with proteinuria in GFP-GABARAP transgenic mice.
Tomino et al., Tokyo, Japan. In Am J Physiol Renal Physiol, 2012
GABARAP/p62 complex is responsible for impairment of glomerular function and that it retards recovery from the effects of doxorubicin.
Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease.
Wakabayashi et al., Hirosaki, Japan. In Neurobiol Dis, 2011
The level of GABARAPs is decreased in Lewy body disease.
Altered GABA(A) receptor expression during epileptogenesis.
Brooks-Kayal et al., Aurora, United States. In Neurosci Lett, 2011
Evidence suggests that changes in the expression and function of GABA(A) receptors are involved in the pathogenesis of epilepsy (review)
Effects of C-terminal modifications of GEC1 protein and gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein (GABARAP), two microtubule-associated proteins, on kappa opioid receptor expression.
Liu-Chen et al., Philadelphia, United States. In J Biol Chem, 2011
because of its stronger binding for hKOPR, GEC1 is able to be recruited by hKOPR sufficiently without membrane association via its C-terminal modification; however, du GABARAP appears to require C-terminal modifications to enhance KOPR expression.
Assessment of GABARAP self-association by its diffusion properties.
Willbold et al., Jülich, Germany. In J Biomol Nmr, 2010
Used diffusion-ordered nuclear magnetic resonance spectroscopy to study the temperature and concentration dependence of the diffusion properties of GABARAP.
Network organization of the human autophagy system.
Harper et al., Boston, United States. In Nature, 2010
The six ATG8 orthologues in humans (MAP1LC3/GABARAP proteins) interact with a cohort of 67 proteins, with extensive binding partner overlap between family members, and frequent involvement of a conserved surface on ATG8 proteins known to interact with LC3-interacting regions in partner proteins.
GABAergic system gene expression predicts clinical outcome in patients with neuroblastoma.
Nagalla et al., Portland, United States. In J Clin Oncol, 2004
Lower levels of gamma-aminobutyric acid (GABA) receptor-associated protein (GABARAP) gene expression predict decreased survival among all patients.
GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.
Olsen et al., Los Angeles, United States. In Nature, 1999
Here we identify a new cellular protein, GABA(A)-receptor-associated protein (GABARAP), which can interact with the gamma2 subunit of GABA(A) receptors.
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