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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

4-aminobutyrate aminotransferase

GABA-transaminase, GABA-T, 4-Aminobutyrate Transaminase, GABA at
main component of the 4-aminobutyrate (GABA) shunt; major inhibitory neurotransmitter [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rdl, ACID, HAD, CAN, V1a
Papers on GABA-transaminase
Contribution of polyamines metabolism and GABA shunt to chilling tolerance induced by nitric oxide in cold-stored banana fruit.
Ying et al., Hangzhou, China. In Food Chem, May 2016
NO treatment increased the activities of diamine oxidase, polyamine oxidase and glutamate decarboxylase, while reduced GABA transaminase activity to lower levels compared with control fruit, which resulted the accumulation of GABA.
Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats.
El-Mas et al., Alexandria, Egypt. In Naunyn Schmiedebergs Arch Pharmacol, Jan 2016
tiagabine (GABA reuptake inhibitor) or vigabatrin (GABA transaminase inhibitor).
Region-specific effects of repeated ketamine administration on the presynaptic GABAergic neurochemistry in rat brain.
Zylinska et al., Łódź, Poland. In Neurochem Int, Dec 2015
Ketamine administration decreased GABA transaminase protein in cortex and striatum (by ∼50% and 30%, respectively), which was reflected in diminished activity of the enzyme.
A study on the involvement of GABA-Transaminase in MCT induced pulmonary hypertension.
Hanif et al., Bareilly, India. In Pulm Pharmacol Ther, Dec 2015
Increased SNS activity is distinguished by elevated level of norepinephrine (NE) and activity of γ-Amino butyric acid Transminase (GABA-T) which degrades GABA, an inhibitory neurotransmitter within the central and peripheral nervous system.
Interactive effects of glutamine and gamma-aminobutyric acid on growth performance and skeletal muscle amino acid metabolism of 22-42-day-old broilers exposed to hot environment.
Jiang et al., China. In Int J Biometeorol, Nov 2015
Compared with the PC group, cyclic HS decreased (P < 0.05) daily weight gain (DWG), daily feed consumption (DFC), the concentrations of Gln, glutamate (Glu), and GABA, and the activities of glutaminase and glutamic acid decarboxylase (GAD) in breast muscle at 28, 35, and 42 days, while it increased (P < 0.05) the activities of glutamine synthetase (GS) and gamma-aminobutyric acid transaminase (GABA-T) at 28, 35, and 42 days.
Genotoxic and mutagenic effects of vigabatrin, a γ-aminobutyric acid transaminase inhibitor, in Wistar rats submitted to rotarod task.
Pereira et al., Porto Alegre, Brazil. In Hum Exp Toxicol, Nov 2015
UNASSIGNED: Vigabatrin (VGB) is an antiepileptic drug thatincreases brain γ-aminobutyric acid (GABA) levels through irreversible inhibition of GABA transaminase.
The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism.
Bonnen et al., Houston, United States. In Cell Metab, Apr 2015
ABAT is a key enzyme responsible for catabolism of principal inhibitory neurotransmitter γ-aminobutyric acid (GABA).
GABAB receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulators.
Cryan et al., Kraków, Poland. In Neuropharmacology, 2015
Over the past fifteen years positive allosteric modulators (PAMs) have emerged that enhance the effects of GABA at GABAB receptors and which may have therapeutic effects similar to those of agonists but with superior side-effect profiles.
Coordination of dendritic inhibition through local disinhibitory circuits.
Topolnik et al., Québec, Canada. In Front Synaptic Neurosci, 2014
It has been recognized for some time that different subtypes of cortical inhibitory interneurons innervate specific dendritic domains of principal cells and release GABA at particular times during behaviorally relevant network oscillations.
How and why does tomato accumulate a large amount of GABA in the fruit?
Ezura et al., Tsukuba, Japan. In Front Plant Sci, 2014
The GABA shunt bypasses two steps (the oxidation of α-ketoglutarate to succinate) of the tricarboxylic acid (TCA) cycle via reactions catalyzed by three enzymes: glutamate decarboxylase, GABA transaminase, and succinic semialdehyde dehydrogenase.
Targeting the modulation of neural circuitry for the treatment of anxiety disorders.
Ratner et al., Boston, United States. In Pharmacol Rev, 2014
These agents reduce anxiety rapidly by allosterically enhancing the postsynaptic actions of GABA at inhibitory type A GABA receptors but side effects limit their use in chronic anxiety disorders.
GABA system as a target for new drugs.
Kulig et al., Kraków, Poland. In Curr Med Chem, 2013
This review is focused on the recent development of compounds which can influence GABA neurotransmission by affecting the GABA receptors, the plasma-membrane GABA transporters (GATs) and catabolic enzyme GABA-transaminase (GABAT).
4-aminobutyrate aminotransferase (ABAT): genetic and pharmacological evidence for an involvement in gastro esophageal reflux disease.
Lagerström-Fermer et al., Mölndal, Sweden. In Plos One, 2010
direct involvement of ABAT in pathways affecting lower esophageal sphincter (LES) control in gastro esophageal reflux disease
A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy.
Osaka et al., Yokohama, Japan. In J Inherit Metab Dis, 2010
excessive prenatal GABA exposure in the central nervous system (CNS) is responsible for the clinical manifestations of GABA transaminase deficiency [case report]
Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT.
International Molecular Genetics Study of Autism Consortium et al., Oxford, United Kingdom. In Am J Hum Genet, 2005
Analysis of the autistic disorder susceptibility locus suggests an association on chromosome 16p between GRIN2A and ABAT.
Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site.
Choi et al., South Korea. In Mol Cells, 2005
lysine 357 is essential for catalytic function of brain GABA transaminase, and is involved in binding PLP at the active site
Cysteine-321 of human brain GABA transaminase is involved in intersubunit cross-linking.
Choi et al., South Korea. In Mol Cells, 2004
results suggest that the Cys321 residue is essential for the catalytic function of GABAT, and that it is involved in the formation of a disulfide link between two monomers of human brain GABAT
Double-blind study of gamma-vinyl GABA in patients with refractory epilepsy.
Richens et al., In Lancet, 1984
Twenty-four patients with frequent drug-resistant seizures took part in a randomised double-blind placebo-controlled crossover trial of the GABA-transaminase inhibitor, gamma-vinyl GABA.
Seizure protection and increased nerve-terminal GABA: delayed effects of GABA transaminase inhibition.
Iadarola et al., In Science, 1980
The net increase in GABA of the denervated nigra was compared with that of the intact nigra at various times after a single injection of gama-vinyl-GABA, which irreversibly inhibits GABA transaminase.
Hyper-beta-alaninemia associated with beta-aminoaciduria and gamma-aminobutyricaciduaia, somnolence and seizures.
Davies et al., Montréal, Canada. In N Engl J Med, 1966
Associated inhibition of GABA transaminase and displacement of GABA from central-nervous-system binding sites would produce GABAuria and convulsions.
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