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Growth factor receptor bound protein 2-associated protein 2

Gab2, Grb2-associated binder 2, pp100
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: Grb2, Akt, PI3K, CAN, apolipoprotein E
Papers using Gab2 antibodies
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes
Grinstein Sergio et al., In The Journal of Cell Biology, 2008
... The mutated Gab2-PH domain was amplified (5′-TCACTCGAGCCCCGAATATGAGCGGC and 3′-ATCGGATCCT­TAGAAGCCGCA­GATCTGGCAG), digested with XhoI and BamHI (New England Biolabs, Inc.), and inserted into ...
A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid–induced neuronal differentiation
Lee Angel W.-M. et al., In The Journal of Cell Biology, 2001
... Rabbit α-Gab2 was purchased from UBI and goat α-Gab2 from Santa Cruz Biotechnology, Inc ...
Papers on Gab2
Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.
Van Etten et al., Toronto, Canada. In Blood, Feb 2016
BCR-ABL1, via phosphorylated Tyr177, recruits the adapter GAB2 as part of a GRB2/GAB2 complex.
Bromo-honaucin A inhibits osteoclastogenic differentiation in RAW 264.7 cells via Akt and ERK signaling pathways.
Soh et al., Chŏnju, South Korea. In Eur J Pharmacol, Jan 2016
The inhibitory effects on in-vitro osteoclastogenesis was evaluated by counting the number of Tartarate resistant acid phospatase (TRAP) positive multinucleated cells and by measuring the expression level of osteoclast-specific genes like matrix metalloproteinase 9 (MMP9), cathepsin K (CATH K), GRB2-associated-binding protein 2 (GAB2), c-terminal myc kinase (C-MYC), C-terminal Src kinase (C-SRC) and Microphthalmia-associated transcription factor (MITF).
Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression.
Cheung et al., Charleston, United States. In Oncogene, Jan 2016
UNASSIGNED: We previously found that the scaffold adapter GRB2-associated binding protein 2 (GAB2) is amplified and overexpressed in a subset of primary high-grade serous ovarian cancers and cell lines.
Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer.
Feng et al., Zunyi, China. In J Exp Clin Cancer Res, Dec 2015
BACKGROUND: Grb2-associated binder 2 (Gab2), a scaffolding adaptor protein, has recently been implicated in cancer progression.
Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1.
Hao et al., Linyi, China. In Mol Neurobiol, Dec 2015
We performed the meta-analysis to obtain a more precise estimation of whether growth factor receptor-bound protein-associated binding protein 2 (GAB2), phosphatidylinositol binding clathrin assembly protein (PICALM), and sortilin-related receptor (SORL1) variants are associated with AD.
Oncogenic Signaling Adaptor Proteins.
Hahn et al., Boston, United States. In J Genet Genomics, Nov 2015
In this review, we focus on the discovery, structure and function, and therapeutic implication of three of these adaptor oncogenes, CRKL, GAB2, and FRS2.
Identification of four new susceptibility loci for testicular germ cell tumour.
Turnbull et al., Oslo, Norway. In Nat Commun, 2014
We identified new risk loci for TGCT at 3q23 (rs11705932, TFDP2, P=1.5 × 10(-9)), 11q14.1 (rs7107174, GAB2, P=9.7 × 10(-11)), 16p13.13
Identification of Personalized Chemoresistance Genes in Subtypes of Basal-Like Breast Cancer Based on Functional Differences Using Pathway Analysis.
Tian et al., Harbin, China. In Plos One, 2014
Based on functional differences among these subgroups, we identified nine biomarkers related to drug resistance: SYK, LCK, GAB2, PAWR, PPARG, MDFI, ZAP70, CIITA and ACTA1.
Grb2-associated binder 2 silencing impairs growth and migration of H1975 cells via modulation of PI3K-Akt signaling.
Yao et al., Laiwu, China. In Int J Clin Exp Pathol, 2014
In this study, we tested our hypothesis that Grb2-associated binder 2 (Gab2) regulate NSCLC cancer cell H1975 malignant biological behaviors, and silencing Gab2 reduced H1975 cellular colony forming ability, migration and invasion.
Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.
Shen et al., Changsha, China. In Plos One, 2014
Risk SNPs included rs9331888 (CLU), rs6691117 (CR1), rs4938933 (MS4A), rs9349407 (CD2AP), rs1160985 (TOMM40), rs4945261 (GAB2) and rs5984894 (PCDH11X); Protective SNPs consisted of rs744373 (BIN1), rs1562990 (MS4A), rs597668 (EXOC3L2), rs9271192 (HLA-DRB5/DRB1), rs157581 and rs11556505 (TOMM40).
GAB2--a scaffolding protein in cancer.
Celebi et al., New York City, United States. In Mol Cancer Res, 2012
Grb2-associated binding protein 2 (GAB2) scaffolding protein is an intermediary molecule that links plasma membrane receptor signaling including receptor tyrosine kinases with the downstream effectors, such as protein tyrosine phosphatase, nonreceptor type 11 (SHP2), p85 subunit of phosphoinositide-3 kinase (PI3-K), phospholipase C-gamma 1 (PLC-γ), v-crk sarcoma virus CT10 (CRK), Src homology 2 domain containing transforming protein 1 (SHC), and SH2 containing inositol phosphatase (SHIP).
Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins.
Thompson et al., Los Angeles, United States. In Twin Res Hum Genet, 2012
significant association between the GAB2 gene and morphological brain differences in 755 young adult twins.(GAB2) has been shown to provide a 1.27-1.51 increased odds of developing late Alzheimer's.
Gab2 regulates the migratory behaviors and E-cadherin expression via activation of the PI3K pathway in ovarian cancer cells.
Gu et al., Aurora, United States. In Oncogene, 2012
Gab2 overexpression, via activation of the PI3K-Zeb1 pathway, promotes characteristics of epithelial-to-mesenchymal transition in ovarian cancer cells
Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.
Yu et al., Ann Arbor, United States. In Mol Cell Biol, 2011
Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion
Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation.
Hirano et al., Yokohama, Japan. In J Immunol, 2011
Both phosphatidylinositol (PI)-3 kinase and SH2 domain-containing protein tyrosine phosphatase (SHP)2 binding sites of Gab2 are required for mast cell degranulation and the anaphylaxis response.
Overexpression of Grb2-associated binder 2 in human lung cancer.
Li et al., Tianjin, China. In Int J Biol Sci, 2010
over-expressed in malignant lung tissues
[Risk factors for Alzheimer's disease].
Yamada et al., Kanazawa, Japan. In Brain Nerve, 2010
In addition, several genes such as CTNNA3, GAB2, PVRL2, TOMM40, and APOC1 are known to be the risk factors that contribute to AD pathogenesis.
Advances and perspectives from genetic research: development of biological markers in Alzheimer's disease.
Hampel et al., München, Germany. In Expert Rev Mol Diagn, 2010
Additional genes, listed online in AlzGene (e.g., GAB2 or SORL1) have repeatedly shown risk effects in LOAD, and may be true risk genes, but this is much less certain.
Genome-wide association studies in Alzheimer's disease.
Tanzi et al., Berlin, Germany. In Hum Mol Genet, 2009
On the basis of the data available at the time of this writing, the most compelling novel GWAS signal has been observed in GAB2 (GRB2-associated binding protein 2), followed by less consistently replicated signals in galanin-like peptide (GALP), piggyBac transposable element derived 1 (PGBD1), tyrosine kinase, non-receptor 1 (TNK1).
A role for the scaffolding adapter GAB2 in breast cancer.
Gu et al., Boston, United States. In Nat Med, 2006
GAB2 may play a role in development of breast cancer
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