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GRB2-associated binding protein 1

Gab1, Grb2-associated binder-1
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: Grb2, NS1, Akt, PI3K, ERK
Papers using Gab1 antibodies
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Supplier
Sundan Anders et al., In European Journal of Haematology, 2002
... Gab1 were from Cell Signaling Technology ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Supplier
Kholodenko Boris N et al., In Molecular Systems Biology, 1998
... (Y317), anti-IGF-1 receptor β (all from Cell Signaling)), anti-phospho-IR β (Y1162/1163), anti-GRB2 (C-23), anti-GAB1 (H-198), anti-phospho-GAB1 (Y627), anti-SH-PTP2 (C-18) (all from Santa Cruz Biotechnology), anti-phospho-EGFR (Y1173), anti-phospho-IRS1 (Y612) ...
Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis
Supplier
Birchmeier Walter et al., In The Journal of Cell Biology, 1993
... Additional point mutations or small deletions (Δ341-348) were introduced into the Gab1 cDNA by site-directed mutagenesis using a commercial kit (CLONTECH Laboratories, Inc.) or by ...
Papers on Gab1
Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.
New
Kiessling et al., Athens, Greece. In Stem Cells Dev, Feb 2016
Fifty-one gene elements were overdetected on the 8C arrays relative to hES/iPS cells, including 14 detected at least 80-fold higher, which annotated to multiple pathways: six cytokine family (CSF1R, IL2RG, IL3RA, IL4, IL17B, IL23R), four transforming growth factor beta (TGFB) family (BMP6, BMP15, GDF9, ENG), one fibroblast growth factor (FGF) family [FGF14(FH4)], one epidermal growth factor member (GAB1), plus CD36, and CLEC10A.
PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling.
New
Jin et al., Rochester, United States. In Cell Signal, Jan 2016
We have previously shown that flow-stimulated Gab1 (Grb2-associated binder-1) tyrosine phosphorylation mediates eNOS activation in ECs, which in part confers laminar flow atheroprotective action.
Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen-induced liver injury in mice.
New
Takehara et al., Suita, Japan. In Hepatology, Jan 2016
Grb2-associated binder 1 (Gab1) adaptor protein plays a crucial role in transmitting signals from growth factor and cytokine receptors to downstream effectors.
EGF augments TGFβ-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1.
New
Lazzara et al., Philadelphia, United States. In J Cell Sci, Dec 2015
Whereas EGF promoted SHP2 binding to tyrosine phosphorylated GAB1, which promotes SHP2 activity, TGFβ did not induce SHP2 association with phosphotyrosine-containing proteins.
1p/14q co-deletion: A determinant of recurrence in histologically benign meningiomas.
New
Suri et al., New Delhi, India. In Indian J Pathol Microbiol, Oct 2015
MATERIALS AND METHODS: We analyzed recurrent meningiomas with paired parent and recurrent tumors by fluorescence in situ hybridization for 1p36 and 14q32 deletion, AKT and SMO mutations by sequencing, and immunohistochemistry for GAB1, progesterone receptor (PR), p53, and MIB-1.
Integrating Molecular Subclassification of Medulloblastomas into Routine Clinical Practice: A Simplified Approach.
New
Sarkar et al., New Delhi, India. In Brain Pathol, Aug 2015
β-catenin, GAB1 and YAP1 were the only IHC markers of utility in classification of MBs into three subgroups viz.
MicroRNAs in B-cell lymphomas: how a complex biology gets more complex.
Review
New
Mraz et al., Brno, Czech Republic. In Leukemia, May 2015
We focus on miR-contribution to the regulation of important signalling pathways (such as NF-κB, PI3K/AKT and TGF-β), BCR signalling and its modulators (such as PTEN, SHIP-1, ZAP-70, GAB1 and BTK), anti- and pro-apoptotic proteins (such as BCL2, MCL1, TCL1, BIM, p53 and SIRT1) and transcription factors (such as MYC, MYB, PU.1, FOXP1 and BCL6).
B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells.
Review
New
Mraz et al., Brno, Czech Republic. In Eur J Haematol, Mar 2015
In lymphoma B cells, the balance of initiation, amplitude and duration of BCR activation can be influenced by a specific immunoglobulin structure, the expression and mutations of adaptor molecules (like GAB1, BLNK, GRB2, CARD11), the activity of kinases (like LYN, SYK, PI3K) or phosphatases (like SHIP-1, SHP-1 and PTEN) and levels of microRNAs.
The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.
GeneRIF
Neel et al., Toronto, Canada. In Mol Cell, 2012
The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3.
Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.
GeneRIF
Farooq et al., Miami, United States. In Febs J, 2012
Data show that bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
Impact
Tamari et al., Yokohama, Japan. In Nat Genet, 2011
In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (combined P = 1.87 × 10(-12)), a locus on chromosome 10p14 (P = 1.79 × 10(-15)) and a gene-rich region on chromosome 12q13 (P = 2.33 × 10(-13)).
Degradation of the GAB1 adaptor by the ubiquitin-proteasome pathway hampers HGF/SF-MET signaling.
GeneRIF
Fafeur et al., Lille, France. In Biochem Biophys Res Commun, 2011
These data demonstrate that GAB1 is ubiquitinated by CBL and degraded by the proteasome, and plays a role in negative-feedback regulation of HGF/SF-MET signaling.
Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis.
GeneRIF
Jin et al., Rochester, United States. In Arterioscler Thromb Vasc Biol, 2011
Gab1 is essential for postnatal angiogenesis through mediating angiogenic and survival signaling.
Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway.
GeneRIF
Luo et al., Beijing, China. In Proc Natl Acad Sci U S A, 2011
Gab1 is a critical upstream signaling component in VEGF-induced eNOS activation and tube formation, which is dependent on protein kinase A.
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.
Impact
Jänne et al., Boston, United States. In Cancer Cell, 2010
We demonstrate that MET activation by its ligand, HGF, also induces drug resistance, but through GAB1 signaling.
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.
Impact
Sikic et al., Stanford, United States. In J Clin Oncol, 2007
This set of 271 differentially expressed genes (including GAB1, CIITA, XBP1, CD83, SERPINB9, PTP4A3, NOV, LOX, CTNND1, BAALC, and RAB21) is enriched for genes involved in cell death, cellular growth and proliferation, and hematologic system development and function.
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades.
Review
Katoh et al., Tokyo, Japan. In Cancer Biol Ther, 2006
FGF signals are transduced through FGF receptor to the FRS2-GRB2-GAB1-PI3K-AKT signaling cascade to downregulate GSK3beta activity depending on Ser 9 phosphorylation.
FGF signaling network in the gastrointestinal tract (review).
Review
Katoh et al., Japan. In Int J Oncol, 2006
Fibroblast growth factor (FGF) signals are transduced through FGF receptors (FGFRs) and FRS2/FRS3- SHP2 (PTPN11)-GRB2 docking protein complex to SOS-RAS-RAF-MAPKK-MAPK signaling cascade and GAB1/GAB2-PI3K-PDK-AKT/aPKC signaling cascade.
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action.
Impact
GeneRIF
Feng et al., Los Angeles, United States. In Nat Med, 2005
Gab1 acts to attenuate, through promotion of the Erk pathway, insulin-elicited signals flowing through IRS and Akt proteins, which represents a novel balancing mechanism for control of insulin signal strength in the liver.
A Grb2-associated docking protein in EGF- and insulin-receptor signalling.
Impact
Wong et al., Philadelphia, United States. In Nature, 1996
Here we use recombinant Grb2 to isolate a complementary DNA called Gab1 (for Grb2-associated binder-1).
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