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GRB2-associated binding protein 1

Gab1, Grb2-associated binder-1
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Papers using Gab1 antibodies
SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
Supplier
Sundan Anders et al., In European Journal of Haematology, 2002
... Gab1 were from Cell Signaling Technology ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Supplier
Kholodenko Boris N et al., In Molecular Systems Biology, 1998
... (Y317), anti-IGF-1 receptor β (all from Cell Signaling)), anti-phospho-IR β (Y1162/1163), anti-GRB2 (C-23), anti-GAB1 (H-198), anti-phospho-GAB1 (Y627), anti-SH-PTP2 (C-18) (all from Santa Cruz Biotechnology), anti-phospho-EGFR (Y1173), anti-phospho-IRS1 (Y612) ...
Tyrosine 1356 in the carboxyl-terminal tail of the HGF/SF receptor is essential for the transduction of signals for cell motility and morphogenesis
Supplier
Birchmeier Walter et al., In The Journal of Cell Biology, 1993
... Additional point mutations or small deletions (Δ341-348) were introduced into the Gab1 cDNA by site-directed mutagenesis using a commercial kit (CLONTECH Laboratories, Inc.) or by ...
Papers on Gab1
The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.
GeneRIF
Neel et al., Toronto, Canada. In Mol Cell, 2012
The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3.
Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.
GeneRIF
Farooq et al., Miami, United States. In Febs J, 2012
Data show that bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.
Degradation of the GAB1 adaptor by the ubiquitin-proteasome pathway hampers HGF/SF-MET signaling.
GeneRIF
Fafeur et al., Lille, France. In Biochem Biophys Res Commun, 2011
These data demonstrate that GAB1 is ubiquitinated by CBL and degraded by the proteasome, and plays a role in negative-feedback regulation of HGF/SF-MET signaling.
Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis.
GeneRIF
Jin et al., Rochester, United States. In Arterioscler Thromb Vasc Biol, 2011
Gab1 is essential for postnatal angiogenesis through mediating angiogenic and survival signaling.
Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway.
GeneRIF
Luo et al., Beijing, China. In Proc Natl Acad Sci U S A, 2011
Gab1 is a critical upstream signaling component in VEGF-induced eNOS activation and tube formation, which is dependent on protein kinase A.
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