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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glycosylphosphatidylinositol anchor attachment protein 1 homolog

GAA1, Gaa1p, GPAA1
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, GPI transamidase, AGE, PIG-U, CAN
Papers on GAA1
Genomic profiling of invasive melanoma cell lines by array comparative genomic hybridization.
New
Balázs et al., Debrecen, Hungary. In Melanoma Res, Jan 2016
GPAA1, PLEC and SHARPIN (8q24.3)
A study of up to 12 years of follow-up of Friedreich ataxia utilising four measurement tools.
New
Delatycki et al., Australia. In J Neurol Neurosurg Psychiatry, Jun 2015
Additional subgroups were created to study the effects of the size of the smaller FXN intron 1 GAA repeat size (GAA1) and onset age on rating scale performance.
Evolutionary engineering of a wine yeast strain revealed a key role of inositol and mannoprotein metabolism during low-temperature fermentation.
Guillamón et al., Paterna, Spain. In Bmc Genomics, 2014
Genome sequencing of the evolved strain revealed the presence of a SNP in the GAA1 gene and the construction of a site-directed mutant (GAA1 (Thr108)) in a derivative haploid of the ancestral strain resulted in improved fermentation performance.
Sensitivity of spatiotemporal gait parameters in measuring disease severity in Friedreich ataxia.
Corben et al., Australia. In Cerebellum, 2014
GAA1 repeat expansion negatively correlated with double-support percentage of the gait cycle in all speed conditions demonstrating a relationship between the genetic mutation and compensatory strategies for impaired dynamic balance.
Identification of novel sphingolipid-binding motifs in mammalian membrane proteins.
von Heijne et al., Stockholm, Sweden. In Biochim Biophys Acta, 2014
From these motif-containing candidate proteins, four with different numbers of transmembrane helices were selected for experimental study: i) major histocompatibility complex II Q alpha chain subtype (DQA1), ii) GPI-attachment protein 1 (GAA1), iii) tetraspanin-7 TSN7, and iv), metabotropic glutamate receptor 2 (GRM2).
Transamidase subunit GAA1/GPAA1 is a M28 family metallo-peptide-synthetase that catalyzes the peptide bond formation between the substrate protein's omega-site and the GPI lipid anchor's phosphoethanolamine.
Eisenhaber et al., Singapore, Singapore. In Cell Cycle, 2013
The transamidase subunit GAA1/GPAA1 is predicted to be the enzyme that catalyzes the attachment of the glycosylphosphatidyl (GPI) lipid anchor to the carbonyl intermediate of the substrate protein at the ω-site.
Enhanced expression and significance of glycosylphosphatidylinositol anchor attachment protein 1 in colorectal cancer.
Zuo et al., Chongqing, China. In Genet Mol Res, 2013
The aim of this study was to investigate the expression of glycosylphosphatidylinositol anchor attachment protein 1 (GPAA1) and its significance in patients with colorectal cancer.
Low-resolution structure of the soluble domain GPAA1 (yGPAA170-247) of the glycosylphosphatidylinositol transamidase subunit GPAA1 from Saccharomyces cerevisiae.
Grüber et al., Singapore, Singapore. In Biosci Rep, 2012
We present the production of the two recombinant proteins yGPAA1⁷⁰⁻²⁴⁷ and yGPAA1⁷⁰⁻³³⁹ of the luminal domain of S. cerevisiae GPAA1, covering the amino acids 70-247 and 70-339 respectively.
Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma.
Abbott et al., Athens, United States. In J Biol Chem, 2012
We also expressed short interfering RNAs targeting the expression of the GPAA1 and PIGT subunits of GPIT in breast cancer cell lines to identify proteins in which membrane localization is dependent on GPI anchor addition.
A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia.
Semsarian et al., Sydney, Australia. In J Mol Cell Cardiol, 2011
The number of GAA repeats on the smaller FXN allele (GAA1) only accounts for a portion of the observed variability in cardiac phenotype.
Purification and crystallization of yeast glycosylphosphatidylinositol transamidase subunit PIG-S (PIG-S(71-467)).
Grüber et al., Singapore, Singapore. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011
The transfer of glycosylphosphatidylinositol (GPI) anchors onto eukaryotic proteins is catalyzed by the transamidase complex, which is composed of at least five subunits (PIG-K, PIG-S, PIG-T, PIG-U and GPAA1).
Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast.
Grüber et al., Singapore, Singapore. In J Struct Biol, 2011
The addition of glycosylphosphatidylinositol (GPI) anchors to eukaryotic proteins in the lumen of the endoplasmic reticulum is catalyzed by the transamidase complex, composed of at least five subunits (PIG-K, PIG-S, PIG-T, PIG-U and GPAA1).
A combined nucleic acid and protein analysis in Friedreich ataxia: implications for diagnosis, pathogenesis and clinical trial design.
Filla et al., Napoli, Italy. In Plos One, 2010
Frataxin levels correlated inversely with GAA1 and GAA2 expansions, and directly with age at onset.
Analysis of the factors influencing the cardiac phenotype in Friedreich's ataxia.
Cooper et al., Oxford, United Kingdom. In Mov Disord, 2010
LV mass was most pronounced in FRDA patients with a larger genetic mutation (GAA1 repeats >600), earlier age of onset (<16years) and a shorter disease duration (<15 years).
A combined voxel-based morphometry and 1H-MRS study in patients with Friedreich's ataxia.
Cendes et al., Campinas, Brazil. In J Neurol, 2009
Mean length of shorter (GAA1) and longer (GAA2) alleles were 735 and 863, respectively.
Alterations of GPI transamidase subunits in head and neck squamous carcinoma.
GeneRIF
Califano et al., Baltimore, United States. In Mol Cancer, 2006
Results show an increased expression level and elevated copy number for GAA1 in head and neck squamous carcinoma, suggesting a role for this GPI anchor subunit in HNSCC.
Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 (GPAA1) is associated with gene amplification in hepatocellular carcinoma.
GeneRIF
Fan et al., Hong Kong, Hong Kong. In Int J Cancer, 2006
Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 is associated with gene amplification in hepatocellular carcinoma
Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex.
GeneRIF
Menon et al., Madison, United States. In J Biol Chem, 2005
passively retained in the ER by a signalless mechanism
A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase.
GeneRIF
Menon et al., Madison, United States. In J Biol Chem, 2004
a conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol recognition by GPI transamidase
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