GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Euchromatic histone-lysine N-methyltransferase 2
G9a
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
Histone, SUV39H1, E4, DNA methyltransferase, H4
Papers using
G9a
antibodies
Pluripotency deficit in clones overcome by clone-clone aggregation: epigenetic complementation?
Supplier
In Nature structural & molecular biology, 2002
... for Dnmt3a and 3b expression vectors, Ken Wright (University of South Florida, Tampa, U.S.A.) for HA-G9a expression vector and Sriharsa Pradhan (New England Biolabs, Ipswich, MA, U.S.A.) for ...
SMART
Supplier
In Retrovirology, 1991
... Anti-SETMAR and anti-G9a antibodies were purchased from Abcam (Cambridge, MA) ...
Papers on
G9a
BIX-01294 increases pig cloning efficiency by improving epigenetic reprogramming of somatic cell nuclei.
New
Beijing, China. In Reproduction, Jan 2016
To explore the role of H3K9me2 and H3K9me in the porcine somatic cell nuclear reprogramming, BIX-01294, known as a specific inhibitor of G9A (histone-lysine methyltransferase of H3K9), was used to treat the nuclear-transferred (NT) oocytes for 14-16 h after activation.
EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos.
New
Illkirch-Graffenstaden, France. In Genome Res, Dec 2015
Previous studies suggested a link between the lysine methyltransferase EHMT2 (also known as G9A and KMT1C) and DNA methylation in the mouse.
Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells.
New
Santa Cruz, United States. In Stem Cell Reports, Dec 2015
Functionally, prevention of heterochromatin formation by inhibition of the histone methyltransferase G9A resulted in delayed HSC differentiation.
Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.
New
Impact
Beijing, China. In Cancer Cell, Jul 2015
Here, we report that GATA3 nucleates a transcription repression program composed of G9A and MTA3-, but not MTA1- or MTA2-, constituted NuRD complex.
Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2.
Review
New
Paris, France. In Antioxid Redox Signal, Jul 2015
SIGNIFICANCE: Methylation of histone H3 on lysine 9 and 27 (H3K9 and H3K27) are two epigenetic modifications that have been linked to several crucial biological processes, among which are transcriptional silencing and cell differentiation.
Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.
New
Cambridge, United States. In Mol Cell Proteomics, Jun 2015
Cell-type specific gene silencing by histone H3 lysine 27 and lysine 9 methyltransferase complexes PRC2 and G9A-GLP is crucial both during development and to maintain cell identity.
Involvement of G9A-like protein (GLP) in the development of mouse preimplantation embryos in vitro.
New
In Reprod Fertil Dev, Jun 2015
UNASSIGNED: G9A-like protein (GLP) plays an important role in mouse early embryonic development.
Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions.
New
Paris, France. In Nucleic Acids Res, Mar 2015
Here, we have investigated how alternative splicing affects the function of two human histone methyltransferases (HMTase): G9A and SUV39H2.
Acyldepsipeptide antibiotics--current state of knowledge.
Review
In Pol J Microbiol, 2014
The researchers' conclusions demonstrated a significant impact on microorganisms including the destabilization of bacterial cell division in Bacillus subtilis 168, Staphylococcus aureus HG001 and Streptococcus pneumoniae G9A strains.
Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis.
Shanghai, China. In Genome Biol, 2014
RESULTS: Here, we show that the lncRNA ROR occupies and activates the TESC promoter by repelling the histone G9A methyltransferase and promoting the release of histone H3K9 methylation.
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.
In J Clin Invest, 2014
Using a murine T cell transfer model of colitis, we found that T cell-intrinsic expression of the histone lysine methyltransferase G9A was required for development of pathogenic T cells and intestinal inflammation.
Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.
North Chicago, United States. In Acs Med Chem Lett, 2014
G9a is a histone lysine methyltransferase responsible for the methylation of histone H3 lysine 9.
The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation.
Impact
Augusta, United States. In Cell Metab, 2014
Here we show that the histone H3 lysine 9 (H3K9) methyltransferase G9A is required for maintaining the pathway enzyme genes in an active state marked by H3K9 monomethylation and for the transcriptional activation of this pathway in response to serine deprivation.
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.
Impact
Boston, United States. In Cell Stem Cell, 2012
L3mbtl2 regulates genes by recruiting a Polycomb Repressive Complex1 (PRC1)-related complex, resembling the previously described E2F6-complex, and including G9A, Hdac1, and Ring1b.
Negative regulation of JAK2 by H3K9 methyltransferase G9a in leukemia.
GeneRIF
Seoul, South Korea. In Mol Cell Biol, 2012
data show that HMTase G9a negatively regulates JAK2 transcription and H3Y41 phosphorylation on the lmo2 promoter; and study provides new insights into G9a function in the regulation of hematopoiesis and leukemogenesis
Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription.
GeneRIF
Los Angeles, United States. In J Cell Biochem, 2012
study concludes that a subset of cancer-related Runx2 target genes require recruitment of G9a for their expression, but do not depend on its histone methyltransferase activity
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.
GeneRIF
Lexington, United States. In J Clin Invest, 2012
Snail interacted with G9a, a major euchromatin methyltransferase responsible for H3K9me2, and recruited G9a and DNA methyltransferases to the E-cadherin promoter for DNA methylation.
Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation.
GeneRIF
Singapore, Singapore. In Proc Natl Acad Sci U S A, 2012
MyoD methylation is critical for G9a-mediated inhibition of myogenesis.
Structure and function of histone H3 lysine 9 methyltransferases and demethylases.
Review
Ann Arbor, United States. In Chembiochem, 2011
In this review, we summarize recent advances in understanding the structure and substrate specificity of the H3K9-specific methyltransferases G9A and GLP and explore current efforts to develop inhibitors of these enzymes.
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
GeneRIF
Atlanta, United States. In Nat Commun, 2010
The MPP8 chromodomain forms a dimer in solution and in crystals, suggesting that a dimeric MPP8 molecule could bridge the methylated Dnmt3a and GLP, resulting in a silencing complex of Dnmt3a-MPP8-GLP/G9a on chromatin templates.
