Sakaguchi et al., Kumamoto, Japan. In J Immunol, Mar 2015
Previous studies show reduced JNK signaling in peritoneal B1a cells of female New Zealand Black mice and an abnormal increase of protein phosphatase 2A subunit G5PR that regulates BCR-mediated JNK signaling as a cause of autoimmunity.
In the present study, we report a regulatory subunit of PP5 (protein phosphatase 5), G4-1, that physically interacts with IKKβ [IκB (inhibitor of NF-κB) kinase β] and negatively regulates NF-κB activation.
Haynes et al., Durham, United States. In J Virol, 2008
Two human monoclonal antibodies (MAbs) (2F5 and 4E10) against the human immunodeficiency virus type 1 (HIV-1) envelope g41 cluster II membrane proximal external region (MPER) broadly neutralize HIV-1 primary isolates.
Sakaguchi et al., Kumamoto, Japan. In Biochem Biophys Res Commun, 2006
We examined the transcription of a protein phosphatase subunit G5PR in immature and mature B-cells, because absence of this factor augmented cell sensitivity to AICD, associated with increased activation of JNK and Bim.
Sakaguchi et al., Kumamoto, Japan. In Genes Cells, 2002
RESULTS: Using the 1 kb fragment (G5) of the ganp cDNA, we identified a clone named G5PR that is structurally homologous to known regulatory subunits of protein phosphatases (PPases) and determined the association of G5PR with GANP in vivo in the DNA transfectant.