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Lactamase, beta

G24, LACTB
This gene encodes a protein from the large 39S subunit of the mitochondrial ribosome (mitoribosome). The encoded protein has some sequence similarity to prokaryotic beta-lactamases but most of the residues that are responsible for the beta-lactamase activity are not conserved between the two proteins. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, fibrillin-1, MM2
Papers on G24
MicroRNA-125b-5p attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production by targeting inhibiting LACTB in THP-1 macrophages.
New
Hu et al., Guangzhou, China. In Arch Biochem Biophys, Dec 2015
BACKGROUND: Increasing evidence has shown that gene beta-lactamases (LACTB) has effect on obesity.
Protocol To Make Protein NMR Structures Amenable to Stable Long Time Scale Molecular Dynamics Simulations.
Brüschweiler et al., Columbus, United States. In J Chem Theory Comput, 2014
The protocol embeds an NMR structure in a native low energy region of the recently developed ff99SB_φψ(g24;CS) molecular mechanics force field.
Iterative Optimization of Molecular Mechanics Force Fields from NMR Data of Full-Length Proteins.
Brüschweiler et al., Tallahassee, United States. In J Chem Theory Comput, 2011
The resulting force fields, termed ff99SB_φψ(g24;CS) and ff99SB_φψ(g8;CS,RDC), perform significantly better than their parent force field in terms of both NMR data reproduction and Cartesian coordinate root-mean-square deviations between the MD trajectories and the X-ray crystal structures.
LACTB is a filament-forming protein localized in mitochondria.
Eriksson et al., Helsinki, Finland. In Proc Natl Acad Sci U S A, 2009
LACTB is a mammalian active-site serine protein that has evolved from a bacterial penicillin-binding protein.
Clinical and genetic risk factors of self-reported penicillin allergy.
Rebbeck et al., Philadelphia, United States. In J Allergy Clin Immunol, 2008
DNA from buccal swabs was genotyped for variants associated with candidate genes linked to immediate hypersensitivity (IL4, IL4R, and IL10) and penicillin metabolism (LACTB).
Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy.
Eriksson et al., Helsinki, Finland. In Bmc Evol Biol, 2007
The emerging role of LACTB, a mammalian mitochondrial PBP-betaL homolog, in metabolic signaling prompted us to investigate the evolutionary history of metazoan PBP-betaL proteins.
An improved beta-lactamase reporter assay: multiplexing with a cytotoxicity readout for enhanced accuracy of hit identification.
GeneRIF
Turek-Etienne et al., Madison, United States. In J Biomol Screen, 2007
An improved LACTB reporter assay is described. Multiplexing with a cytotoxicity readout enhancs accuracy of hit identification.
Expression and purification of the mitochondrial serine protease LACTB as an N-terminal GST fusion protein in Escherichia coli.
Eriksson et al., Helsinki, Finland. In Protein Expr Purif, 2006
LACTB is a mammalian mitochondrial protein sharing sequence similarity to the beta-lactamase/penicillin-binding protein family of serine proteases that are involved in bacterial cell wall metabolism.
Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine.
Koprowski et al., Philadelphia, United States. In Vaccine, 2002
Samsun NN plants providing replicative functions in trans for full-length infectious RNA3 of AlMV (NF1-g24).
Differential expression of a novel gene in response to hsp27 and cell differentiation in human keratinocytes.
GeneRIF
Trautinger et al., Vienna, Austria. In J Invest Dermatol, 2002
Differential expression of a novel gene, G24, in response to hsp27 and cell differentiation in human keratinocytes.(G24 PROTEIN)
Characterization of all the elastic, dielectric, and piezoelectric constants of uniaxially oriented poled PVDF films.
Varadan et al., Taegu, South Korea. In Ieee Trans Ultrason Ferroelectr Freq Control, 2002
The elastic constants c44D and C55D, the dielectric constants epsilon11T and epsilon22T, as well as the piezoelectric constants g15 and g24 reported here have not been published before.
Conserved, N-linked carbohydrates of human immunodeficiency virus type 1 gp41 are largely dispensable for viral replication.
Desrosiers et al., United States. In J Virol, 2001
The four single mutants (g1, g2, g3, and g4) and all six double mutants (g12, g13, g14, g23, g24, and g34) replicated in both human and rhesus monkey T-cell lines, as well as in primary rhesus peripheral blood mononuclear cells.
Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain.
Debouck et al., King of Prussia, United States. In Genomics, 2001
Database searching with bacterial serine beta-lactamases identified mouse expressed sequence tags (ESTs) with significant similarity scores.The cloned mouse cDNA encodes a novel 551-amino-acid protein, LACTB, with a predicted amino-terminal transmembrane domain but no signal peptide.
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