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Interferon, alpha-inducible protein 6

G1P3, IFI-6-16, IFI6, GIP3
This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ISG15, MxA, 18 U, STAT1
Papers on G1P3
Interferon-inducible Protein 6-16 (IFI-6-16, ISG16) promotes Hepatitis C virus replication in vitro.
Chen et al., Chengdu, China. In J Med Virol, Jan 2016
Interferon-inducible protein 6-16 (IFI-6-16, ISG16) is one of the interferon stimulated genes (ISGs) whose expression levels can be induced by type I interferons.
Isolation and characterization of mesenchymal stem cells from the yolk sacs of bovine embryos.
Ambrósio et al., Pirassununga, Brazil. In Theriogenology, Nov 2015
Gene expression analyses showed no differences in the patterns of gene expression between the groups or passages tested, with the exception of the expression of SOX2, which was slightly different in the G1P3 group compared to the other groups.
Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection.
Ray et al., Saint-Louis, Senegal. In Sci Rep, 2014
We examined the effect of interferon-α inducible protein 6 (IFI6) against HCV infection in human hepatoma cells.
Type I interferon related genes are common genes on the early stage after vaccination by meta-analysis of microarray data.
Liang et al., Beijing, China. In Hum Vaccin Immunother, 2014
Six of which were type I interferon (IFN) related genes, including LY6E, MX1, OAS3, IFI44L, IFI6 and IFITM3.
IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells.
Huang et al., Guangzhou, China. In Plos One, 2014
Among ISGs, IFN-α inducible gene 6 (IFI6) was increased in DENV infected human umbilical vascular endothelial cells (HUVECs) by microarray analysis in our previous study.
Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection.
Gui et al., Guangzhou, China. In Mol Cell Biochem, 2014
Interferon-alpha-inducible protein 6 (IFI6), a putative apoptosis regulator, inhibited DENV2-induced autophagy in EA.hy926 cells, while XAF1, an inhibitor of anti-apoptotic XIAP, facilitated autophagy.
Gene expression profiling to predict and assess the consequences of therapy-induced virus eradication in chronic hepatitis C virus infection.
Boonstra et al., Rotterdam, Netherlands. In J Virol, 2014
These ISGs included the CXCL10, OAS1, IFI6, DDX60, TRIM5, and STAT1 genes.
Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus.
Zhang et al., Wuhan, China. In Dev Comp Immunol, 2014
Among the 137 putative immune-related genes derived from this library, these molecules received particular focus: immunoglobulin heavy chains (IgM, IgD, and IgY), IFN-inducible protein 6 (IFI6), and T cell receptor beta chain (TCRβ).
Early bovine embryos regulate oviduct epithelial cell gene expression during in vitro co-culture.
Locatelli et al., France. In Anim Reprod Sci, 2014
Of these 34 genes, IFI6, ISG15, MX1, IFI27, IFI44, RSAD2, IFITM1, EPSTI1, USP18, IFIT5, and STAT1 expression increased to the greatest extent due to the presence of embryos with a major impact on antiviral and immune response.
Hepatitis E genotype 4 virus from feces of monkeys infected experimentally can be cultured in PLC/PRF/5 cells and upregulate host interferon-inducible genes.
Wang et al., Beijing, China. In J Med Virol, 2014
Four interferon-inducible genes, IFI27, IFI6, Mx1, and CMPK2, were up-regulated during HEV-infection.
AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.
Feng et al., Beijing, China. In Cell Immunol, 2014
Based on GO, KEGG, GenMAPP, BioCarta and disease databases, we determined AGR2-mediated lung adenocarcinoma metastasis through repression with cytoskeleton of MAST1; steroid metabolism of SOAT2; humoral immune response of POU2AF1; interferon alpha-inducible of IFI6; immunoglobulin of IGKC_3, CTA_246H3.1.
Unveiling transcription factor regulation and differential co-expression genes in Duchenne muscular dystrophy.
Huang et al., Xuzhou, China. In Diagn Pathol, 2013
Among the DEGs which shared TFs with DMD, six genes were co-expressed with DMD, including ATP1A2, C1QB, MYOF, SAT1, TRIP10, and IFI6.
G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer.
Borden et al., Cleveland, United States. In Oncogene, 2012
Here we elucidate G1P3, a survival protein induced by interferons (IFNs), as a target of estrogen signaling and a contributor to poor outcomes in estrogen receptor-positive (ER(+)) breast cancer.
A diverse range of gene products are effectors of the type I interferon antiviral response.
Rice et al., New York City, United States. In Nature, 2011
Broadly acting effectors included IRF1, C6orf150 (also known as MB21D1), HPSE, RIG-I (also known as DDX58), MDA5 (also known as IFIH1) and IFITM3, whereas more targeted antiviral specificity was observed with DDX60, IFI44L, IFI6, IFITM2, MAP3K14, MOV10, NAMPT (also known as PBEF1), OASL, RTP4, TREX1 and UNC84B (also known as SUN2).
Emerging roles of FAM14 family members (G1P3/ISG 6-16 and ISG12/IFI27) in innate immunity and cancer.
Borden et al., Cleveland, United States. In J Interferon Cytokine Res, 2011
Here, we review the regulation and cellular functions of 2 related ISGs, ISG12 (IFI27) and G1P3 (ISG 6-16), that are commonly induced by IFNs in most, if not all, IFN-responsive cells.
The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS.
Széll et al., Szeged, Hungary. In Exp Dermatol, 2010
PRINS regulates G1P3, a gene with anti-apoptotic effects in keratinocytes. siRNA-mediated inhibition of PRINS gene resulted in altered cell morphology and gene expression alterations.
Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7.
Lesage et al., Montréal, Canada. In Bmc Genomics, 2007
Authors found 245 genes required for the normal growth of the Glc7 mutant.
Inhibition of G1P3 expression found in the differential display study on respiratory syncytial virus infection.
Zhang et al., Wuhan, China. In Virol J, 2007
Respiratory syncytial virus upregulated the mRNA expression of chemokines CC and CXC and interfered with type alpha/beta interferon-inducible gene expression by upregulation of MG11 and downregulation of G1P3.
G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.
Borden et al., Cleveland, United States. In J Clin Invest, 2007
IFN-alpha2b induced the expression of G1P3 and antagonized the TRAIL induced apoptosis in myeloma suggesting that either the deregulated or the induced expression of G1P3 could lead to apoptosis resistance in tumor cells.
Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II.
de Lanerolle et al., Chicago, United States. In Nat Cell Biol, 2004
Chromatin immunoprecipitation assays demonstrated the recruitment of actin to the promoter region of the interferon-gamma-inducible MHC2TA gene as well as the interferon-alpha-inducible G1P3 gene.
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