G1 to S phase transition
miR-382 targeting PTEN-Akt axis promotes liver regeneration.
Shanghai, China. In Oncotarget, Jan 2016
miR-382 overexpression accelerated the proliferation and the G1 to S phase transition of the cell cycle both in mouse NCTC1469 and human HL7702 normal liver cells, while miR-382 downregulation had inverse effects.
tRNA traffic meets a cell-cycle checkpoint.
Tucson, United States. In Cell, 2007
Findings by Ghavidel et al. (2007) reported in this issue suggest that tRNA trafficking and the transcription factor Gcn4 are key intermediates in the process by which yeast cells detect DNA damage and delay cell-cycle progression at the G1 to S phase transition.
Rb function in cell-cycle regulation and apoptosis.
Saint Louis, United States. In Nat Cell Biol, 2000
One regulator of the critical G1 to S-phase transition in the cell cycle is the retinoblastoma tumour suppressor protein Rb, which interacts with the E2F family of cell-cycle transcription factors to repress gene transcription required for this transition.